In this issue of Blood, , Leyte-Vidal et al use cell-viability assays, molecular simulations, and drug-binding studies to demonstrate that BCR::ABL1 :: ABL1 N-lobe mutants, such as M244V, confer resistance to asciminib, adding another potential mechanism of resistance to this drug.1 1
Shedding light on resistance to asciminib / Breccia, Massimo. - In: BLOOD. - ISSN 0006-4971. - 144:6(2024), pp. 594-595. [10.1182/blood.2024024851]
Shedding light on resistance to asciminib
Breccia, Massimo
2024
Abstract
In this issue of Blood, , Leyte-Vidal et al use cell-viability assays, molecular simulations, and drug-binding studies to demonstrate that BCR::ABL1 :: ABL1 N-lobe mutants, such as M244V, confer resistance to asciminib, adding another potential mechanism of resistance to this drug.1 1File allegati a questo prodotto
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