This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.
Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma / Hernández-Esparza, M. J.; Fratoddi, Ilaria; Cerra, Sara; Juarez-Moreno, K.; Huirache-Acuña, R.. - In: NANOSCALE ADVANCES. - ISSN 2516-0230. - 5:24(2023), pp. 7077-7085. [10.1039/D3NA00605K]
Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma
Ilaria FratoddiSecondo
;Sara Cerra;
2023
Abstract
This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.| File | Dimensione | Formato | |
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