Background Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was firstly described in 2016. Since NIFTP is thought a non-malignant tumor, the Bethesda system for thyroid cytology proposes two estimations of risk of malignancy of the diagnostic categories, one considering NIFTP as cancer and another one considering it as a benign neoplasm. The present study aimed to review NIFTPs in a single center, re-assess them across categories of three Thyroid Imaging Reporting and Data Systems (TIRADSs), and define the indication for biopsy according to the category-specific size cut-offs.Methods The study period was from 2017 to 2023. The institutional database was searched for histologically proven NIFTPs with preoperative ultrasound images. NIFTPs were re-assessed according to the American College of Radiology (ACR), European (EU), and Korean (K) TIRADSs. The indication for biopsy was defined according to TIRADS category-specific size threshold.Results Twenty NIFTPs from 19 patients were included. The median size of the NIFTPs was 23 mm. According to ultrasound, 80-85% of NIFTPs were at low-intermediate risk and 5-15% at high risk without significant difference among the tree TIRADSs (p = 0.91). The indication for FNA, according to three TIRADSs, was found in 52-58% of cases with no significant difference among systems (p = 0.96).Conclusion NIFTPs have heterogeneous presentation according to TIRADSs with very low indication rate for FNA.

NIFTP-adjusted risk estimation of Bethesda thyroid cytology categories should consider the indication for FNA according to TIRADS / Leoncini, Andrea; Camponovo, Chiara; Gamarra, Elena; Piticchio, Tommaso; Ruinelli, Lorenzo; Rotondi, Mario; Cantisani, Vito; Treglia, Giorgio; Trimboli, Pierpaolo. - In: ENDOCRINE. - ISSN 1559-0100. - 85:3(2024). [10.1007/s12020-024-03800-9]

NIFTP-adjusted risk estimation of Bethesda thyroid cytology categories should consider the indication for FNA according to TIRADS

Leoncini, Andrea;Cantisani, Vito;Trimboli, Pierpaolo
2024

Abstract

Background Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was firstly described in 2016. Since NIFTP is thought a non-malignant tumor, the Bethesda system for thyroid cytology proposes two estimations of risk of malignancy of the diagnostic categories, one considering NIFTP as cancer and another one considering it as a benign neoplasm. The present study aimed to review NIFTPs in a single center, re-assess them across categories of three Thyroid Imaging Reporting and Data Systems (TIRADSs), and define the indication for biopsy according to the category-specific size cut-offs.Methods The study period was from 2017 to 2023. The institutional database was searched for histologically proven NIFTPs with preoperative ultrasound images. NIFTPs were re-assessed according to the American College of Radiology (ACR), European (EU), and Korean (K) TIRADSs. The indication for biopsy was defined according to TIRADS category-specific size threshold.Results Twenty NIFTPs from 19 patients were included. The median size of the NIFTPs was 23 mm. According to ultrasound, 80-85% of NIFTPs were at low-intermediate risk and 5-15% at high risk without significant difference among the tree TIRADSs (p = 0.91). The indication for FNA, according to three TIRADSs, was found in 52-58% of cases with no significant difference among systems (p = 0.96).Conclusion NIFTPs have heterogeneous presentation according to TIRADSs with very low indication rate for FNA.
2024
Bethesda; NIFTP; TIRADS; Thyroid nodule; Ultrasound
01 Pubblicazione su rivista::01a Articolo in rivista
NIFTP-adjusted risk estimation of Bethesda thyroid cytology categories should consider the indication for FNA according to TIRADS / Leoncini, Andrea; Camponovo, Chiara; Gamarra, Elena; Piticchio, Tommaso; Ruinelli, Lorenzo; Rotondi, Mario; Cantisani, Vito; Treglia, Giorgio; Trimboli, Pierpaolo. - In: ENDOCRINE. - ISSN 1559-0100. - 85:3(2024). [10.1007/s12020-024-03800-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1720692
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