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Objectives: Hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU) are common life-threatening events. We wanted to investigate the association between early adequate antibiotic therapy and 28-day mortality in ICU patients surviving for at least 1 day after the onset of HA-BSI. Methods: We used individual data from a prospective, observational, multicenter, intercontinental cohort study (Eurobact2). We included patients followed for ≥1 day for whom time-to-appropriate treatment was available. We used an adjusted frailty-Cox proportional hazard model to assess the effect of time-to-treatment-adequacy on 28-day mortality. Infection- and patient-related variables identified as confounders by the Directed Acyclic Graph were used for adjustment. Adequate therapy within 24 hours was used for primary analysis. Secondary analyses were performed for adequate therapy within 48 and 72 hours and for identified patient subgroups. Results: Among the 2,418 patients included in 330 centers worldwide, 28-day mortality was 32.8% (n=402/1226) in patients who were adequately treated within 24 hours after HA-BSI onset and 40% (n=477/1192) in inadequately treated patients (p<0.01). Adequacy within 24 hours was more common in young, immunosuppressed patients, and with HA-BSI due to Gram-negative pathogens. Antimicrobial adequacy was significantly associated with 28-day survival (aHR 0.83, 95% CI 0.72-0.96, p=0.01). The estimated population attributable fraction (PAF) of 28-day mortality of inadequate therapy was 9.15% (95% CI 1.9%-16.2%). Conclusions: In patients with HA-BSI admitted in ICU, the PAF of 28-day mortality of inadequate therapy within 24 hours was 9.15%. This estimate should be used when hypothesizing the possible benefit of any intervention aiming at reducing the time-to-appropriate antimicrobial therapy in HA-BSI.

Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on ICU patient prognosis: a causal inference approach using data from the Eurobact2 study / Loiodice, Ambre; Bailly PharmD, Sébastien; Ruckly, Stéphane; Buetti, Niccolò; Barbier, François; Staiquly, Quentin; Tabah, Alexis; Timsit, Jean-François; Tabah, Alexis; Lipman, Jeffrey; Tabah, Alexis; Pollock, Hamish; Ben Margetts, Null; Udy, Andrew; Young, Meredith; Bhadange, Neeraj; Tyler, Steven; Ledtischke, Anne; Finnis, Mackenzie; Dwivedi, Jyotsna; Saxena, Manoj; Biradar, Vishwanath; Soar, Natalie; Sarode, Vineet; Brewster, David; Regli, Adrian; Weeda, Elizabeth; Ahmed, Samiul; Fourie, Cheryl; Laupland, Kevin; Ramanan, Mahesh; Walsham, James; Meyer, Jason; Litton, Edward; Maria Palermo, Anna; Yap, Timothy; Eroglu, Ege; George Attokaran, Antony; Jaramillo, C'Havala; Nafees, Khalid Mk; Nafees, Khalid Mahmood Khan; Aqilah Haji Abd Rashid, Nurhikmahtul; Adi Muhamad Ibnu Walid, Haji; Mon, Tomas; Dhakshina Moorthi, P.; Sudhirchandra, Shah; Sridharan, Dhadappa Damodar; Haibo, Qiu; Xie, Jianfeng; Haibo, Qiu; Jianfeng, Xie; Wei-Hua, Lu; Zhen, Wang; Qian, Chuanyun; Luo, Jili; Chen, Xiaomei; Wang, Hao; Zhao, Peng; Zhao, Juan; Wusi, Qiu; Mingmin, Chen; Xu, Lei; Yin, Chengfen; Wang, Ruilan; Wang, Jinfeng; Yin, Yongjie; Zhang, Min; Ye, Jilu; Hu, Chungfang; Zhou, Suming; Huang, Min; Yan, Jing; Wang, Yan; Qin, Bingyu; Ye, Ling; Weifeng, Xie; Peije, Li; Geng, Nan; Ling, Lowell; Ling, Lowell; Hayashi, Yoshiro; Hayashi, Yoshiro; Karumai, Toshiyuki; Yamasaki, Masaki; Hashimoto, Satoru; Hosokawa, Koji; Makino, Jun; Matsuyoshi, Takeo; Kuriyama, Akira; Shigemitsu, Hidenobu; Mishima, Yuka; Nagashima, Michio; Yoshida, Hideki; Fujitani, Shigeki; Omori, Koichiro; Rinka, Hiroshi; Saito, Hiroki; Atobe, Kaori; Kato, Hideaki; Takaki, Shunsuke; Sulaiman, Helmi; Shahnaz Hasan, M.; Fadhil Hadi Jamaluddin, Muhamad; Pheng, Lee See; Visvalingam, Sheshendrasurian; Thing Liew, Mun; Ling Danny Wong, Siong; Khang Fong, Kean; Bt Abdul Rahman, Hamizah; Md Noor, Zuraini; Lee, Kok Tong; Hamid Azman, Abd.; Zulfakar Mazlan, Mohd; Ali, Saedah; Hernandez, Aaron Mark; Abello, Anton; Jeon, Kyeongman; Jeon, Kyeongman; Lee, Sang-Min; Park, Sunghoon; Park, Seung Yong; Yoon Lim, Sung; Kwa, Andrea Lay Hoon; Yuan Goh, Qing; Yuan Goh, Qing; Ng, Shin Yi; An Lie, Sui; Kwa, Andrea Lay Hoon; Junyang Goh, Ken; Yunkai Li, Andrew; Ong, Caroline Yu Ming; Yan Lim, Jia; Lishan Quah, Jessica; Ng, Kangqi; Xiang Long Ng, Louis; Yeh, Tony Yu-Chang; Chang Yeh, Yu; Chou, Nai-Kuan; Cia, Cong-Tat; Hu, Ting-Yu; Kuo, Li-Kuo; Ku, Shih-Chi; Wongsurakiat, Phunsup; Wongsurakiat, Phunsup; Apichatbutr, Yutthana; Chiewroongroj, Supattra; Alsisi, Adel; Nadeem, Rashid; El Houfi, Ashraf; Alsisi, Adel; Alsisi, Adel; Elhadidy, Amr; Barsoum, Mina; Osman, Nermin; Mostafa, Tarek; Elbahnasawy, Mohamed; Saber, Ahmed; Aldhalia, Amer; Elmandouh, Omar; Elsayed, Ahmed; Elbadawy, Merihan A.; Awad, Ahmed K.; Hemead, Hanan M.; Zand, Farid; Zand, Farid; Ouhadian, Maryam; Hamid Borsi, Seyed; Mehraban, Zahra; Kashipazha, Davood; Ahmadi, Fatemeh; Savaie, Mohsen; Soltani, Farhad; Rashidi, Mahboobeh; Baghbanian, Reza; Javaherforoosh, Fatemeh; Amiri, Fereshteh; Kiani, Arash; Amin Zargar, Mohammad; Mahmoodpoor, Ata; Aalinezhad, Fatemeh; Dabiri, Gholamreza; Sabetian, Golnar; Sarshad, Hakimeh; Masjedi, Mansoor; Tajvidi, Ramin; Nasirodin (S. M. N. ) Tabatabaei, Dr Seyed Mohammad; Ahmed, Abdullah Khudhur; Singer, Pierre; Singer, Pierre; Kagan, Ilya; Rigler, Merav; Belman, Daniel; Levin, Phillip; Harara, Belal; Diab, Adei; Abillama, Fayez; Abilama, Fayez; Ibrahim, Rebecca; Fares, Aya; Elhadi, Muhammed; Buimsaedah, Ahmad; Gamra, Marwa; Aqeelah, Ahmed; Ali Mohammed Ali, Almajdoub; Gaber Sadik Homaidan, Ahmed; Almiqlash, Bushray; Bilkhayr, Hala; Bouhuwaish, Ahmad; Sa Taher, Ahmed; Abdulwahed, Eman; Abousnina, Fathi A.; Khaled Hdada, Aisha; Jobran, Rania; Ben Hasan, Hayat; Shaban Ben Hasan, Rabab; Khalid Abidi, Null; Serghini, Issam; Seddiki, Rachid; Boukatta, Brahim; Kanjaa, Nabil; Mouhssine, Doumiri; Ahmed Wajdi, Maazouzi; Dendane, Tarek; Ali Zeggwagh, Amine; Housni, Brahim; Younes, Oujidi; Hachimi, Abdelhamid; Ghannam, A.; Belkhadir, Z.; Abu Jayyab, Mustafa; Aithssain, Ali; Lance, Marcus; Nissar, Shaikh; Sallam, Hend; Elrabi, Omar; Almekhlafi, Ghaleb A.; Awad, Maher; Aljabbary, Ahmed; Karam Chaaban, Mohammad; Abu-Sayf, Natalia; Al-Jadaan, Mohammad; Bakr, Lubna; Mounir Bouaziz, Null; Bouaziz, Mounir; Turki, Olfa; Sellami, Walid; Vidal, Gabriela; Centeno, Pablo; Morvillo, Natalia; Oscar Acevedo, José; Mabel Lopez, Patricia; Fernández, Rubén; Segura, Matías; Aparicio, Marta; Alonzo, Irene; Nuccetelli, Yanina; Montefiore, Pablo; Arias, Mario; Felipe Reyes, Luis; Felipe Reyes, Luis; Ñamendys-Silva, Silvio A.; Ñamendys-Silva, Silvio A.; Romero-Gonzalez, Juan P.; Hermosillo, Mariana; Alejandro Castillo, Roberto; Nicolás Pantoja Leal, Jesús; Garcia Aguilar, Candy; Ocotlan Gonzalez Herrera, Mara; Vladimir Espinoza Villafuerte, Missael; Lomeli-Teran, Manuel; Dominguez-Cherit, Jose G.; Davalos-Alvarez, Adrian; Ñamendys-Silva, Silvio A.; Sánchez-Hurtado, Luis; Tejeda-Huezo, Brigitte; Perez-Nieto, Orlando R.; Deloya Tomas, Ernesto; De Bus, Liesbet; De Waele, Jan; Francois, Guy; De Bus, Liesbet; De Waele, Jan; Hollevoet, Isabelle; Denys, Wouter; Bourgeois, Marc; Vanderhaeghen, Sofie F. M.; Mesland, Jean-Baptiste; Henin, Pierre; Haentjens, Lionel; Biston, Patrick; Noel, Cindérella; Layos, Nathalie; Misset, Benoît; De Schryver, Nicolas; Serck, Nicolas; Wittebole, Xavier; De Waele, Elisabeth; Opdenacker, Godelive; Kovacevic, Pedja; Kovacevic, Pedja; Zlojutro, Biljana; Ina, Filipovic-Grcic; Custovic, Aida; Filipovic-Grcic, Ina; Radonic, Radovan; Vujaklija Brajkovic, Ana; Persec, Jasminka; Sakan, Sanja; Nikolic, Mario; Lasic, Hrvoje; Leone, Marc; Timsit, Jean-François; Ruppe, Etienne; Ruckly, Stephane; Montravers, Philippe; Leone, Marc; Arbelot, Charlotte; Timsit, Jean-François; Patrier, Juliette; Zappela, N.; Montravers, P.; Dulac, Thierry; Castanera, Jérémy; Auchabie, Johann; Le Meur, Anthony; Marchalot, A.; Beuzelin, M.; Massri, Alexandre; Guesdon, Charlotte; Escudier, Etienne; Mateu, Philippe; Rosman, Jérémy; Leroy, Olivier; Alfandari, Serge; Nica, Alexandru; Souweine, Bertrand; Coupez, Elisabeth; Duburcq, Thibault; Kipnis, Eric; Bortolotti, Perrine; Le Souhaitier, Mathieu; Mira, Jean-Paul; Garcon, Pierre; Duprey, Matthieu; Thyrault, Martial; Paulet, Rémi; Philippart, François; Tran, Marc; Bruel, Cédric; Weiss, Emmanuel; Janny, Sylvie; Foucrier, Arnaud; Perrigault, Pierre-François; Djanikian, Flora; Barbier, François; Gainnier, Marc; Bourenne, Jérémy; Louis, Guillaume; Smonig, Roland; Argaud, Laurent; Baudry, Thomas; Mekonted Dessap, Armand; Razazi, Keyvan; Kalfon, Pierre; Badre, Gaëtan; Larcher, Romaric; Lefrant, Jean-Yves; Roger, Claire; Sarton, Benjamine; Silva, Stein; Demeret, Sophie; Le Guennec, Loïc; Siami, Shidasp; Aparicio, Christelle; Voiriot, Guillaume; Fartoukh, Muriel; Dahyot-Fizelier, Claire; Imzi, Nadia; Klouche, Kada; Bracht, Hendrik; Bracht, Hendrik; Hoheisen, Sandra; Bloos, Frank; Thomas-Rueddel, Daniel; Petros, Sirak; Pasieka, Bastian; Dubler, Simon; Schmidt, Karsten; Gottschalk, Antje; Wempe, Carola; Lepper, Philippe; Metz, Carlos; Viderman, Dmitriy; Viderman, Dmitriy; Umbetzhanov, Yerlan; Mugazov, Miras; Bazhykayeva, Yelena; Kaligozhin, Zhannur; Babashev, Baurzhan; Merenkov, Yevgeniy; Temirov, Talgat; Arvaniti, Kostoula; Arvaniti, Kostoula; Smyrniotis, Dimitrios; Psallida, Vasiliki; Fildisis, Georgios; Soulountsi, Vasiliki; Kaimakamis, Evangelos; Iasonidou, Cristina; Papoti, Sofia; Renta, Foteini; Vasileiou, Maria; Romanou, Vasiliki; Koutsoukou, Vasiliki; Kristina Matei, Mariana; Moldovan, Leora; Karaiskos, Ilias; Paskalis, Harry; Marmanidou, Kyriaki; Papanikolaou, M.; Kampolis, C.; Oikonomou, Marina; Kogkopoulos, Evangelos; Nikolaou, Charikleia; Sakkalis, Anastasios; Chatzis, Marinos; Georgopoulou, Maria; Efthymiou, Anna; Chantziara, Vasiliki; Sakagianni, Aikaterini; Athanasa (Athanassa), Zoi (Zoe); Papageorgiou, Eirini; Ali, Fadi; Dimopoulos, Georges; Panagiota Almiroudi, Mariota; Malliotakis, Polychronis; Marouli, Diamantina; Theodorou, Vasiliki; Retselas, Ioannis; Kouroulas, Vasilios; Papathanakos, Georgios; Bassetti, Matteo; Giacobbe, Daniele; Montrucchio, Giorgia; Sales, Gabriele; De Pascale, Gennaro; Maria Montini, Luca; Carelli, Simone; Vargas, Joel; Di Gravio, Valentina; Roberto Giacobbe, Daniele; Gratarola, Angelo; Porcile, Elisa; Mirabella, Michele; Daroui, Ivan; Lodi, Giovanni; Zuccaro, Francesco; Grazia Schlevenin, Maria; Pelosi, Paolo; Battaglini, Denise; Cortegiani, Andrea; Ippolito, Mariachiara; Bellina, Davide; Di Guardo, Andrea; Pelagalli, Lorella; Covotta, Marco; Rocco, Monica; Fiorelli, Silvia; Cotoia, Antonella; Chiara Rizzo, Anna; Adam Mikstacki, Null; Mikstacki, Adam; Tamowicz, Barbara; Kaptur Komorowska, Irmina; Szczesniak, Anna; Bojko, Jozef; Kotkowska, Anna; Walczak-Wieteska, Paulina; Wasowska, Dominika; Nowakowski, Tomasz; Broda, Hanna; Mariusz Peichota, Assoc; Pietraszek-Grzywaczewska, Iwona; Martin-Loeches, Ignacio; Bisanti, Alessandra; Paiva, José Artur; Póvoa, Pedro; Cartoze, Nuno; Pereira, Tiago; Guimarães, Nádia; Alves, Madalena; Josefina Pinheiro Marques, Ana; Rios Pinto, Ana; Krystopchuk, Andriy; Teresa, Ana; Manuel Pereira de Figueiredo, António; Botelho, Isabel; Duarte, Tiago; Costa, Vasco; Pedro Cunha, Rui; Molinos, Elena; Tito da Costa, Null; Ledo, Sara; Queiró, Joana; Pascoalinho, Dulce; Nunes, Cristina; Pedro Moura, José; Pereira, Énio; Carvalho Mendes, António; Valeanu, Liana; Valeanu, Liana; Bubenek-Turconi, Serban; Marina Grintescu, Ioana; Cobilinschi, Cristian; Carmen Filipescu, Daniela; Elena Predoi, Cornelia; Tomescu, Dana; Popescu, Mihai; Marcu, Alexandra; Grigoras, Ioana; Lungu, Olguta; Gritsan, Alexey; Gritsan, Alexey; Anderzhanova, Anastasia; Meleshkina, Yulia; Magomedov, Marat; Zubareva, Nadezhda; Tribulev, Maksim; Gaigolnik, Denis; Eremenko, Aleksandr; Vistovskaya, Natala; Chukina, Maria; Belskiy, Vladislav; Furman, Mikhail; Ferrer Rocca, Ricard; Ferrer Rocca, Ricard; Martinez, Maria; Casares, Vanessa; Mellado Artigas, Ricard; Vera, Paula; Flores, Matias; Amador Amerigo, Joaquin; Gracia Arnillas, Maria Pilar; Munoz Bermudez, Rosana; Armestar, Fernando; Catalan, Beatriz; Roig, Regina; Raguer, Laura; Dolores Quesada, María; Diaz Santos, Emilio; Gomà, Gemma; Ubeda, Alejandro; Salgado, Maria; Forcelledo Espina, Lorena; Garcia Prieto, Emilio; Asensio, Mj; Rodriguez, M.; Maseda, Dr Emilio; Suarez De La Rica, Alejandro; Ignacio Ayestaran, J.; Novo, Mariana; Blasco-Navalpotro, Miguel Angel; Orejas Gallego, Alberto; Sjovall, Fredrik; Sjövall, Fredrik; Spahic, Dzana; Johan Svensson, Carl; Haney, Michael; Edin, Alicia; Åkerlund, Joyce; De Geer, Lina; Prazak, Josef; Buetti, Niccolò; Prazak, Josef; Jakob, Stephan; Pagani, Jl; Abed-Maillard, S.; Akova, Murat; Tarık Aslan, Abdullah; Akova, Murat; Tarik Aslan, Abdullah; Timuroglu, Arif; Kocagoz, Sesin; Kusoglu, Hulya; Mehtap, Selcuk; Ceyhun, Solakoğlu; Altintas, Dr. Neriman Defne; Talan, Leyla; Kayaaslan, Bircan; Kaya Kalem, Ayşe; Kurt, Dr. Ibrahim; Telli, Murat; Ozturk, Barcin; Erol, Çiğdem; Dindar Demiray, Emine Kubra; Çolak, Sait; Akbas, Türkay; Dr. Kursat Gundogan, Null; Sari, Ali; Agalar, Canan; Çolak, Onur; Baykam, Nurcan (N); Akdogan, Ozlem (O); Yilmaz, Mesut; Tunay, Burcu; Cakmak, Rumeysa; Saltoglu, Nese; Karaali, Ridvan; Iftihar Koksal, Null; Firdevs Aksoy, Null; Eroglu, Ahmet; Tolga Saracoglu, Kemal; Bilir, Yeliz; Guzeldag, Seda; Ersoz, Gulden; Evik, Guliz; Sungurtekin, Hulya; Ozgen, Cansu; Erdoğan, Cem; Gürbüz, Yunus; Altin, Nilgün; Bayindir, Yasar; Ersoy, Yasemin; Goksu, Senay; Akyol, Ahmet; Dr, Kartal; Batirel, Ayse; Cagan Aktas, Sabahat; Morris, Andrew Conway; Conway Morris, Andrew; Routledge, Matthew; Conway Morris, Andrew; Ercole, Ari; Antcliffe, David; Rojo, Roceld; Tizard, Kate; Faulkner, Maria; Cowton, Amanda; Kent, Melanie; Raj, Ashok; Zormpa, Artemis; Tinaslanidis, George; Khade, Reena; Torlinski, Tomasz; Mulhi, Randeep; Goyal, Shraddha; Bajaj, Manan; Soltan, Marina; Yonan, Aimee; Dolan, Rachael; Johnson, Aimee; Macfie, Caroline; Lennard, James; Templeton, Maie; Sousa Arias, Sonia; Franke, Uwe; Hugill, Keith; Angell, Hollie; Benjamin J Parcell, Null; Cobb, Katherine; Cole, Stephen; Smith, Tim; Graham, Clive; Cerman, Jaroslav; Keegan, Allison; Ritzema, Jenny; Sanderson, Amanda; Roshdy, Ashraf; Szakmany, Tamas; Baumer, Tom; Longbottom, Rebecca; Hall, Daniel; Tatham, Kate; Loftus, S.; Husain, A.; Black, E.; Jhanji, S.; Rao Baikady, R.; Mcguigan, Peter; Mckee, Rachel; Kannan, Santhana; Antrolikar, Supriya; Marsden, Nicholas; Della Torre, Valentina; Banach, Dorota; Zaki, Ahmed; Jackson, Matthew; Chikungwa, Moses; Attwood, Ben; Patel, Jamie; Rebecca E Tilley, Null; Humphreys, Sally K.; Jean Renaud, Paul; Sokhan, Anton; Burma, Yaroslava; Sligl, Wendy; Sligl, Wendy; Baig, Nadia; Mccoshen, Lorena; Kutsogiannis, Demetrios J.; Sligl, Wendy; Thompson, Patricia; Hewer, Tayne; Rabbani, Raihan; Rabbani, Raihan; Huq, Shihan Mahmud Redwanul; Hasan, Rajib; Motiul Islam, Mohammad; Gurjar, Mohan; Gurjar, Mohan; Baronia, Arvind; Kothari, Nikhil; Sharma, Ankur; Karmakar, Saurabh; Sharma, Priya; Nimbolkar, Janardan; Samdani, Pratit; Vaidyanathan, R.; Ahmedi Rubina, Noor; Jain, Nikhilesh; Pahuja, Madhumati; Singh, Ritu; Shekhar, Saurav; Syed, Nabeel Muzaffar; Ozair, Ahmad; Sarwar Siddiqui, Suhail; Bose, Payel; Datta, Avijatri; Rathod, Darshana; Patel, Mayur; Mk, Renuka; Sailaja, K Baby; Dsilva, Carol; Chandran, Jagadish; Ghosh, Pralay; Mukherjee, Sudipta; Sheshala, Kaladhar; Chandra Misra, Krushna; Adekola, Oyebola O.; Yusuf Yakubu, Saidu; Mgbosoro Ugwu, Euphemia; Olatosi, John (O); Desalu, Ibironke; Asiyanbi, Gabriel; Oladimeji, Motunrayo; Idowu, Olusola; Adeola, Fowotade; Mer, Mervyn; Mer, Mervyn; Mc Cree, Melanie; El Sanousi, Dr. Bashir; Adil Ali Karar, Ali; Saidahmed, Elfayadh; Hamid, Hytham K. S.. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - (2024). [10.1016/j.cmi.2024.09.011]

Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on ICU patient prognosis: a causal inference approach using data from the Eurobact2 study

Rocco, Monica;Fiorelli, Silvia;
2024

Abstract

Objectives: Hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU) are common life-threatening events. We wanted to investigate the association between early adequate antibiotic therapy and 28-day mortality in ICU patients surviving for at least 1 day after the onset of HA-BSI. Methods: We used individual data from a prospective, observational, multicenter, intercontinental cohort study (Eurobact2). We included patients followed for ≥1 day for whom time-to-appropriate treatment was available. We used an adjusted frailty-Cox proportional hazard model to assess the effect of time-to-treatment-adequacy on 28-day mortality. Infection- and patient-related variables identified as confounders by the Directed Acyclic Graph were used for adjustment. Adequate therapy within 24 hours was used for primary analysis. Secondary analyses were performed for adequate therapy within 48 and 72 hours and for identified patient subgroups. Results: Among the 2,418 patients included in 330 centers worldwide, 28-day mortality was 32.8% (n=402/1226) in patients who were adequately treated within 24 hours after HA-BSI onset and 40% (n=477/1192) in inadequately treated patients (p<0.01). Adequacy within 24 hours was more common in young, immunosuppressed patients, and with HA-BSI due to Gram-negative pathogens. Antimicrobial adequacy was significantly associated with 28-day survival (aHR 0.83, 95% CI 0.72-0.96, p=0.01). The estimated population attributable fraction (PAF) of 28-day mortality of inadequate therapy was 9.15% (95% CI 1.9%-16.2%). Conclusions: In patients with HA-BSI admitted in ICU, the PAF of 28-day mortality of inadequate therapy within 24 hours was 9.15%. This estimate should be used when hypothesizing the possible benefit of any intervention aiming at reducing the time-to-appropriate antimicrobial therapy in HA-BSI.
2024
Critically ill; Directed acyclic graph; Hospital-acquired bloodstream infection; Mediation analysis; Sepsis; Time-to-antibiotic therapy; adequacy
01 Pubblicazione su rivista::01a Articolo in rivista
Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on ICU patient prognosis: a causal inference approach using data from the Eurobact2 study / Loiodice, Ambre; Bailly PharmD, Sébastien; Ruckly, Stéphane; Buetti, Niccolò; Barbier, François; Staiquly, Quentin; Tabah, Alexis; Timsit, Jean-François; Tabah, Alexis; Lipman, Jeffrey; Tabah, Alexis; Pollock, Hamish; Ben Margetts, Null; Udy, Andrew; Young, Meredith; Bhadange, Neeraj; Tyler, Steven; Ledtischke, Anne; Finnis, Mackenzie; Dwivedi, Jyotsna; Saxena, Manoj; Biradar, Vishwanath; Soar, Natalie; Sarode, Vineet; Brewster, David; Regli, Adrian; Weeda, Elizabeth; Ahmed, Samiul; Fourie, Cheryl; Laupland, Kevin; Ramanan, Mahesh; Walsham, James; Meyer, Jason; Litton, Edward; Maria Palermo, Anna; Yap, Timothy; Eroglu, Ege; George Attokaran, Antony; Jaramillo, C'Havala; Nafees, Khalid Mk; Nafees, Khalid Mahmood Khan; Aqilah Haji Abd Rashid, Nurhikmahtul; Adi Muhamad Ibnu Walid, Haji; Mon, Tomas; Dhakshina Moorthi, P.; Sudhirchandra, Shah; Sridharan, Dhadappa Damodar; Haibo, Qiu; Xie, Jianfeng; Haibo, Qiu; Jianfeng, Xie; Wei-Hua, Lu; Zhen, Wang; Qian, Chuanyun; Luo, Jili; Chen, Xiaomei; Wang, Hao; Zhao, Peng; Zhao, Juan; Wusi, Qiu; Mingmin, Chen; Xu, Lei; Yin, Chengfen; Wang, Ruilan; Wang, Jinfeng; Yin, Yongjie; Zhang, Min; Ye, Jilu; Hu, Chungfang; Zhou, Suming; Huang, Min; Yan, Jing; Wang, Yan; Qin, Bingyu; Ye, Ling; Weifeng, Xie; Peije, Li; Geng, Nan; Ling, Lowell; Ling, Lowell; Hayashi, Yoshiro; Hayashi, Yoshiro; Karumai, Toshiyuki; Yamasaki, Masaki; Hashimoto, Satoru; Hosokawa, Koji; Makino, Jun; Matsuyoshi, Takeo; Kuriyama, Akira; Shigemitsu, Hidenobu; Mishima, Yuka; Nagashima, Michio; Yoshida, Hideki; Fujitani, Shigeki; Omori, Koichiro; Rinka, Hiroshi; Saito, Hiroki; Atobe, Kaori; Kato, Hideaki; Takaki, Shunsuke; Sulaiman, Helmi; Shahnaz Hasan, M.; Fadhil Hadi Jamaluddin, Muhamad; Pheng, Lee See; Visvalingam, Sheshendrasurian; Thing Liew, Mun; Ling Danny Wong, Siong; Khang Fong, Kean; Bt Abdul Rahman, Hamizah; Md Noor, Zuraini; Lee, Kok Tong; Hamid Azman, Abd.; Zulfakar Mazlan, Mohd; Ali, Saedah; Hernandez, Aaron Mark; Abello, Anton; Jeon, Kyeongman; Jeon, Kyeongman; Lee, Sang-Min; Park, Sunghoon; Park, Seung Yong; Yoon Lim, Sung; Kwa, Andrea Lay Hoon; Yuan Goh, Qing; Yuan Goh, Qing; Ng, Shin Yi; An Lie, Sui; Kwa, Andrea Lay Hoon; Junyang Goh, Ken; Yunkai Li, Andrew; Ong, Caroline Yu Ming; Yan Lim, Jia; Lishan Quah, Jessica; Ng, Kangqi; Xiang Long Ng, Louis; Yeh, Tony Yu-Chang; Chang Yeh, Yu; Chou, Nai-Kuan; Cia, Cong-Tat; Hu, Ting-Yu; Kuo, Li-Kuo; Ku, Shih-Chi; Wongsurakiat, Phunsup; Wongsurakiat, Phunsup; Apichatbutr, Yutthana; Chiewroongroj, Supattra; Alsisi, Adel; Nadeem, Rashid; El Houfi, Ashraf; Alsisi, Adel; Alsisi, Adel; Elhadidy, Amr; Barsoum, Mina; Osman, Nermin; Mostafa, Tarek; Elbahnasawy, Mohamed; Saber, Ahmed; Aldhalia, Amer; Elmandouh, Omar; Elsayed, Ahmed; Elbadawy, Merihan A.; Awad, Ahmed K.; Hemead, Hanan M.; Zand, Farid; Zand, Farid; Ouhadian, Maryam; Hamid Borsi, Seyed; Mehraban, Zahra; Kashipazha, Davood; Ahmadi, Fatemeh; Savaie, Mohsen; Soltani, Farhad; Rashidi, Mahboobeh; Baghbanian, Reza; Javaherforoosh, Fatemeh; Amiri, Fereshteh; Kiani, Arash; Amin Zargar, Mohammad; Mahmoodpoor, Ata; Aalinezhad, Fatemeh; Dabiri, Gholamreza; Sabetian, Golnar; Sarshad, Hakimeh; Masjedi, Mansoor; Tajvidi, Ramin; Nasirodin (S. M. 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Mira, Jean-Paul; Garcon, Pierre; Duprey, Matthieu; Thyrault, Martial; Paulet, Rémi; Philippart, François; Tran, Marc; Bruel, Cédric; Weiss, Emmanuel; Janny, Sylvie; Foucrier, Arnaud; Perrigault, Pierre-François; Djanikian, Flora; Barbier, François; Gainnier, Marc; Bourenne, Jérémy; Louis, Guillaume; Smonig, Roland; Argaud, Laurent; Baudry, Thomas; Mekonted Dessap, Armand; Razazi, Keyvan; Kalfon, Pierre; Badre, Gaëtan; Larcher, Romaric; Lefrant, Jean-Yves; Roger, Claire; Sarton, Benjamine; Silva, Stein; Demeret, Sophie; Le Guennec, Loïc; Siami, Shidasp; Aparicio, Christelle; Voiriot, Guillaume; Fartoukh, Muriel; Dahyot-Fizelier, Claire; Imzi, Nadia; Klouche, Kada; Bracht, Hendrik; Bracht, Hendrik; Hoheisen, Sandra; Bloos, Frank; Thomas-Rueddel, Daniel; Petros, Sirak; Pasieka, Bastian; Dubler, Simon; Schmidt, Karsten; Gottschalk, Antje; Wempe, Carola; Lepper, Philippe; Metz, Carlos; Viderman, Dmitriy; Viderman, Dmitriy; Umbetzhanov, Yerlan; Mugazov, Miras; Bazhykayeva, Yelena; Kaligozhin, Zhannur; 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Costa, Vasco; Pedro Cunha, Rui; Molinos, Elena; Tito da Costa, Null; Ledo, Sara; Queiró, Joana; Pascoalinho, Dulce; Nunes, Cristina; Pedro Moura, José; Pereira, Énio; Carvalho Mendes, António; Valeanu, Liana; Valeanu, Liana; Bubenek-Turconi, Serban; Marina Grintescu, Ioana; Cobilinschi, Cristian; Carmen Filipescu, Daniela; Elena Predoi, Cornelia; Tomescu, Dana; Popescu, Mihai; Marcu, Alexandra; Grigoras, Ioana; Lungu, Olguta; Gritsan, Alexey; Gritsan, Alexey; Anderzhanova, Anastasia; Meleshkina, Yulia; Magomedov, Marat; Zubareva, Nadezhda; Tribulev, Maksim; Gaigolnik, Denis; Eremenko, Aleksandr; Vistovskaya, Natala; Chukina, Maria; Belskiy, Vladislav; Furman, Mikhail; Ferrer Rocca, Ricard; Ferrer Rocca, Ricard; Martinez, Maria; Casares, Vanessa; Mellado Artigas, Ricard; Vera, Paula; Flores, Matias; Amador Amerigo, Joaquin; Gracia Arnillas, Maria Pilar; Munoz Bermudez, Rosana; Armestar, Fernando; Catalan, Beatriz; Roig, Regina; Raguer, Laura; Dolores Quesada, María; Diaz Santos, Emilio; Gomà, Gemma; Ubeda, Alejandro; Salgado, Maria; Forcelledo Espina, Lorena; Garcia Prieto, Emilio; Asensio, Mj; Rodriguez, M.; Maseda, Dr Emilio; Suarez De La Rica, Alejandro; Ignacio Ayestaran, J.; Novo, Mariana; Blasco-Navalpotro, Miguel Angel; Orejas Gallego, Alberto; Sjovall, Fredrik; Sjövall, Fredrik; Spahic, Dzana; Johan Svensson, Carl; Haney, Michael; Edin, Alicia; Åkerlund, Joyce; De Geer, Lina; Prazak, Josef; Buetti, Niccolò; Prazak, Josef; Jakob, Stephan; Pagani, Jl; Abed-Maillard, S.; Akova, Murat; Tarık Aslan, Abdullah; Akova, Murat; Tarik Aslan, Abdullah; Timuroglu, Arif; Kocagoz, Sesin; Kusoglu, Hulya; Mehtap, Selcuk; Ceyhun, Solakoğlu; Altintas, Dr. Neriman Defne; Talan, Leyla; Kayaaslan, Bircan; Kaya Kalem, Ayşe; Kurt, Dr. Ibrahim; Telli, Murat; Ozturk, Barcin; Erol, Çiğdem; Dindar Demiray, Emine Kubra; Çolak, Sait; Akbas, Türkay; Dr. Kursat Gundogan, Null; Sari, Ali; Agalar, Canan; Çolak, Onur; Baykam, Nurcan (N); Akdogan, Ozlem (O); Yilmaz, Mesut; Tunay, Burcu; Cakmak, Rumeysa; 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Sarwar Siddiqui, Suhail; Bose, Payel; Datta, Avijatri; Rathod, Darshana; Patel, Mayur; Mk, Renuka; Sailaja, K Baby; Dsilva, Carol; Chandran, Jagadish; Ghosh, Pralay; Mukherjee, Sudipta; Sheshala, Kaladhar; Chandra Misra, Krushna; Adekola, Oyebola O.; Yusuf Yakubu, Saidu; Mgbosoro Ugwu, Euphemia; Olatosi, John (O); Desalu, Ibironke; Asiyanbi, Gabriel; Oladimeji, Motunrayo; Idowu, Olusola; Adeola, Fowotade; Mer, Mervyn; Mer, Mervyn; Mc Cree, Melanie; El Sanousi, Dr. Bashir; Adil Ali Karar, Ali; Saidahmed, Elfayadh; Hamid, Hytham K. S.. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - (2024). [10.1016/j.cmi.2024.09.011]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1720434
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