We explore the interaction between corneal immunity and mesenchymal stem/stromal cells (MSCs) and their potential in treating corneal and ocular surface disorders. We outline the cornea's immune privilege mechanisms and the immunomodulatory substances involved. In this realm, MSCs are characterized by their immunomodulatory properties and regenerative potential, making them promising for therapeutic application. Therefore, we focus on the role of MSCs in immune-mediated corneal diseases such as dry eye disease, corneal transplantation rejection, limbal stem cell deficiency, and ocular graft-versus-host disease. Preclinical and clinical studies demonstrate MSCs' efficacy in promoting corneal healing and reducing inflammation in these conditions. Overall, we emphasize the potential of MSCs as innovative therapies in ophthalmology, offering promising solutions for managing various ocular surface pathologies.
Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders / Surico, Pier Luigi; Barone, Vincenzo; Singh, Rohan Bir; Coassin, Marco; Blanco, Tomas; Dohlman, Thomas H; Basu, Sayan; Chauhan, Sunil K; Dana, Reza; Di Zazzo, Antonio. - In: SURVEY OF OPHTHALMOLOGY. - ISSN 0039-6257. - 70:3(2025), pp. 467-479. [10.1016/j.survophthal.2024.07.008]
Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders
Surico, Pier LuigiPrimo
Conceptualization
;Barone, VincenzoSecondo
Writing – Original Draft Preparation
;
2025
Abstract
We explore the interaction between corneal immunity and mesenchymal stem/stromal cells (MSCs) and their potential in treating corneal and ocular surface disorders. We outline the cornea's immune privilege mechanisms and the immunomodulatory substances involved. In this realm, MSCs are characterized by their immunomodulatory properties and regenerative potential, making them promising for therapeutic application. Therefore, we focus on the role of MSCs in immune-mediated corneal diseases such as dry eye disease, corneal transplantation rejection, limbal stem cell deficiency, and ocular graft-versus-host disease. Preclinical and clinical studies demonstrate MSCs' efficacy in promoting corneal healing and reducing inflammation in these conditions. Overall, we emphasize the potential of MSCs as innovative therapies in ophthalmology, offering promising solutions for managing various ocular surface pathologies.| File | Dimensione | Formato | |
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Surico_postprint_Potential applications_2024.pdf
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Surico_Potential applications_2025.pdf
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Note: This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ).
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