In the 20 years since its introduction to the palette of intravenous hemodynamic therapies, the inodilator levosimendan has established itself as a valuable asset for the management of acute decompensated heart failure. Its pharmacology is notable for delivering inotropy via calcium sensitization without an increase in myocardial oxygen consumption.

An update on levosimendan in acute cardiac care: applications and recommendations for optimal efficacy and safety / Heringlake, Matthias; Alvarez, Julian; Bettex, Dominique; Bouchez, Stefaan; Fruhwald, Sonja; Girardis, Massimo; Grossini, Elena; Guarracino, Fabio; Herpain, Antoine; Toller, Wolfgang; Tritapepe, Luigi; Pollesello, Piero. - In: EXPERT REVIEW OF CARDIOVASCULAR THERAPY. - ISSN 1477-9072. - (2021). [10.1080/14779072.2021.1905520]

An update on levosimendan in acute cardiac care: applications and recommendations for optimal efficacy and safety

Tritapepe, Luigi
Validation
;
2021

Abstract

In the 20 years since its introduction to the palette of intravenous hemodynamic therapies, the inodilator levosimendan has established itself as a valuable asset for the management of acute decompensated heart failure. Its pharmacology is notable for delivering inotropy via calcium sensitization without an increase in myocardial oxygen consumption.
2021
Critical care; calciumsensitization; adenosinetriphosphate-sensitivepotassium (KATP) channels;mitochondria;levosimendan; cardiogenicshock; acute heart failure;low cardiac outputsyndrome
01 Pubblicazione su rivista::01a Articolo in rivista
An update on levosimendan in acute cardiac care: applications and recommendations for optimal efficacy and safety / Heringlake, Matthias; Alvarez, Julian; Bettex, Dominique; Bouchez, Stefaan; Fruhwald, Sonja; Girardis, Massimo; Grossini, Elena; Guarracino, Fabio; Herpain, Antoine; Toller, Wolfgang; Tritapepe, Luigi; Pollesello, Piero. - In: EXPERT REVIEW OF CARDIOVASCULAR THERAPY. - ISSN 1477-9072. - (2021). [10.1080/14779072.2021.1905520]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1720049
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact