Type 1 diabetes is one of the major concerns in current medical studies. Traditional clinical practice involves non-autonomous manual injection of insulin in the blood, while current research in the field of autonomous regulation of blood glucose concentration mostly focuses on model-based control techniques. This paper introduces a novel Reinforcement Learning-based controller for autonomous glycemic regulation in the treatment of type 1 diabetes, building on the Deep Deterministic Policy Gradient algorithm. The proposed control method is validated through in-vitro simulations on the Bergman glucoregulatory model, proving that it successfully preserves healthy values of blood glucose concentration, while overcoming both standard clinical practice and classical model-based control techniques in terms of both control effort and computational efficiency for real-time applications.

Deep Deterministic Policy Gradient Control of Type 1 Diabetes / Baldisseri, Federico; Menegatti, Danilo; Wrona, Andrea. - (2024), pp. 868-873. (Intervento presentato al convegno 2024 European Control Conference (ECC) tenutosi a Stoccolma) [10.23919/ecc64448.2024.10591007].

Deep Deterministic Policy Gradient Control of Type 1 Diabetes

Baldisseri, Federico
;
Menegatti, Danilo;Wrona, Andrea
2024

Abstract

Type 1 diabetes is one of the major concerns in current medical studies. Traditional clinical practice involves non-autonomous manual injection of insulin in the blood, while current research in the field of autonomous regulation of blood glucose concentration mostly focuses on model-based control techniques. This paper introduces a novel Reinforcement Learning-based controller for autonomous glycemic regulation in the treatment of type 1 diabetes, building on the Deep Deterministic Policy Gradient algorithm. The proposed control method is validated through in-vitro simulations on the Bergman glucoregulatory model, proving that it successfully preserves healthy values of blood glucose concentration, while overcoming both standard clinical practice and classical model-based control techniques in terms of both control effort and computational efficiency for real-time applications.
2024
2024 European Control Conference (ECC)
Deep Reinforcement Learning; Deep Deterministic Policy Gradient; Type 1 Diabetes.
04 Pubblicazione in atti di convegno::04b Atto di convegno in volume
Deep Deterministic Policy Gradient Control of Type 1 Diabetes / Baldisseri, Federico; Menegatti, Danilo; Wrona, Andrea. - (2024), pp. 868-873. (Intervento presentato al convegno 2024 European Control Conference (ECC) tenutosi a Stoccolma) [10.23919/ecc64448.2024.10591007].
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Note: DOI 10.23919/ECC64448.2024.1059100
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1717319
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