Transthyretin-mediated amyloidosis (ATTR) is a systemic disease with protein precipitation in many tissues, mainly the peripheral nerve and heart. Both genetic (ATTRv, “v” for variant) and wild-type (ATTRwt) forms are known. Beyond the steric encumbrance, precipitated transthyretin Citation: Fiore, M.; Cambieri, C.; Libonati, L.; Moret, F.; D’Andrea, E.; Di Certo, M.G.; Passananti, C.; Gabanella, F.; Corbi, N.; Garibaldi, M.; et al. Oxidative Stress in Transthyretin-Mediated Amyloidosis: AnExploratory Study. Antioxidants 2024, 13, 998. https://doi.org/ 10.3390/antiox13080998 Academic Editor: Donatella Pietraforte Received: 10 July 2024 Revised: 13 August 2024 Accepted: 16 August 2024 Published: 18 August 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). seemstohaveatoxiceffect. In this study carried out in men, we recruited 15 ATTRv patients, 7 ATTRv asymptomatic carriers, 14 ATTRwt patients and 10 young and 13 old healthy controls to evaluate the oxidative stress using FORD (Free Oxygen Radicals Defense) and FORT (Free Oxygen Radicals Test) analyses. ATTRv patients showed reduced FORD compared to ATTRwt and ATTRv asymptomatic carriers. FORD independently predicted the disease stage, with the early stages characterized by the highest consumption. These findings suggest a role for oxidative stress in the early stages of ATTRv.
Oxidative Stress in Transthyretin-Mediated Amyloidosis: An Exploratory Study / Fiore, Marco; Cambieri, Chiara; Grazia Di Certo, Maria; Libonati, Laura; Passananti, Claudio; Moret, Federica; D’Andrea, Edoardo; Gabanella, Francesca; Corbi, Nicoletta; Chimenti, Cristina; Alfarano, Maria; Ferraguti, Giampiero; Francati, Silvia; Garibaldi, Matteo; Inghilleri, Maurizio; Ceccanti, Marco. - In: ANTIOXIDANTS. - ISSN 2076-3921. - (2024). [10.3390/antiox13080998]
Oxidative Stress in Transthyretin-Mediated Amyloidosis: An Exploratory Study
Chiara CambieriSecondo
;Laura Libonati;Federica Moret;Edoardo D’Andrea;Nicoletta Corbi;Cristina Chimenti;Maria Alfarano;Giampiero Ferraguti;Silvia Francati;Matteo Garibaldi;Maurizio Inghilleri;Marco CeccantiUltimo
2024
Abstract
Transthyretin-mediated amyloidosis (ATTR) is a systemic disease with protein precipitation in many tissues, mainly the peripheral nerve and heart. Both genetic (ATTRv, “v” for variant) and wild-type (ATTRwt) forms are known. Beyond the steric encumbrance, precipitated transthyretin Citation: Fiore, M.; Cambieri, C.; Libonati, L.; Moret, F.; D’Andrea, E.; Di Certo, M.G.; Passananti, C.; Gabanella, F.; Corbi, N.; Garibaldi, M.; et al. Oxidative Stress in Transthyretin-Mediated Amyloidosis: AnExploratory Study. Antioxidants 2024, 13, 998. https://doi.org/ 10.3390/antiox13080998 Academic Editor: Donatella Pietraforte Received: 10 July 2024 Revised: 13 August 2024 Accepted: 16 August 2024 Published: 18 August 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). seemstohaveatoxiceffect. In this study carried out in men, we recruited 15 ATTRv patients, 7 ATTRv asymptomatic carriers, 14 ATTRwt patients and 10 young and 13 old healthy controls to evaluate the oxidative stress using FORD (Free Oxygen Radicals Defense) and FORT (Free Oxygen Radicals Test) analyses. ATTRv patients showed reduced FORD compared to ATTRwt and ATTRv asymptomatic carriers. FORD independently predicted the disease stage, with the early stages characterized by the highest consumption. These findings suggest a role for oxidative stress in the early stages of ATTRv.File | Dimensione | Formato | |
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