This study utilizes CFD technique to simulate the inactivation of E. coli bacteria within a microfluidic chamber, employing gold nanoparticles irradiated by a laser beam. Employing a single-phase model, the presence of bacteria is considered by treating thermal properties in the governing equations as effective, combining those of water and bacteria using established correlations from scientific literature. The conversion of light into heat is modeled with parameters derived from scientific literature, featuring a defined source term quantifying the converted light into heat. Introducing a User Defined Scalar (UDS) employing a first-order kinetic model described by the Arrhenius equation for the decay coefficient captures the bacteria’s response to irradiation. A dedicated User Defined Function (UDF) is developed to implement this model, allowing the simulation to account for the reduction in bacterial concentration over time. The results uncover intricate dynamics in bacterial response to laser-induced thermal effects, showcasing the potential for effective bacterial control. Furthermore, the model is rigorously validated against experimental data, affirming its accuracy and robustness in reproducing real-world thermal effects.

Bacterial inactivation via laser-driven gold nanoparticle heating: simulation and analysis / Ziolkowski, P.; Koulali, A.; Radomski, P.; De Biase, D.; Zaccagnini, F.; Zielinski, J.; Pikula, M.; Jeong, K.; Petronella, F.; De Sio, L.; Mikielewicz, D.. - (2024), pp. 715-726. (Intervento presentato al convegno 9th Thermal and Fluids Engineering Conference, TFEC 2024 tenutosi a Oregon State University, Corvallis, OR, USA) [10.1615/TFEC2024.bio.051260].

Bacterial inactivation via laser-driven gold nanoparticle heating: simulation and analysis

De Biase D.;Zaccagnini F.;De Sio L.;
2024

Abstract

This study utilizes CFD technique to simulate the inactivation of E. coli bacteria within a microfluidic chamber, employing gold nanoparticles irradiated by a laser beam. Employing a single-phase model, the presence of bacteria is considered by treating thermal properties in the governing equations as effective, combining those of water and bacteria using established correlations from scientific literature. The conversion of light into heat is modeled with parameters derived from scientific literature, featuring a defined source term quantifying the converted light into heat. Introducing a User Defined Scalar (UDS) employing a first-order kinetic model described by the Arrhenius equation for the decay coefficient captures the bacteria’s response to irradiation. A dedicated User Defined Function (UDF) is developed to implement this model, allowing the simulation to account for the reduction in bacterial concentration over time. The results uncover intricate dynamics in bacterial response to laser-induced thermal effects, showcasing the potential for effective bacterial control. Furthermore, the model is rigorously validated against experimental data, affirming its accuracy and robustness in reproducing real-world thermal effects.
2024
9th Thermal and Fluids Engineering Conference, TFEC 2024
bacteria inactivation; cfd; first order kinetic model; heat transfer; phototermoablation
04 Pubblicazione in atti di convegno::04b Atto di convegno in volume
Bacterial inactivation via laser-driven gold nanoparticle heating: simulation and analysis / Ziolkowski, P.; Koulali, A.; Radomski, P.; De Biase, D.; Zaccagnini, F.; Zielinski, J.; Pikula, M.; Jeong, K.; Petronella, F.; De Sio, L.; Mikielewicz, D.. - (2024), pp. 715-726. (Intervento presentato al convegno 9th Thermal and Fluids Engineering Conference, TFEC 2024 tenutosi a Oregon State University, Corvallis, OR, USA) [10.1615/TFEC2024.bio.051260].
File allegati a questo prodotto
File Dimensione Formato  
Ziolkowski_bacterial-inactivation_2024.pdf

solo gestori archivio

Note: articolo inviato all'Editore, precedente alla peer -review
Tipologia: Documento in Pre-print (manoscritto inviato all'editore, precedente alla peer review)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.67 MB
Formato Adobe PDF
1.67 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1716857
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact