BackgroundIsolate features of the coronary anatomy have been associated with the pathophysiology of atherosclerotic disease. Computational methods have been described to allow precise quantification of the complex three-dimensional (3D) coronary geometry. The present study tested whether quantitative parameters that describe the spatial 3D coronary geometry is associated with the extension and composition of the underlying coronary artery disease (CAD). MethodsPatients with CAD scheduled for percutaneous intervention were investigated with coronary computed tomography angiography (CCTA), and invasive coronary angiography, and virtual histology intravascular ultrasound (IVUS-VH). For all target vessels, 3D centerlines were extracted from CCTA images and processed to quantify 23 geometric indexes, grouped into 3 main categories as follows: (i) length-based; (ii) curvature-based, torsion-based, and curvature/torsion-combined; (iii) vessel path-based. The geometric variables were compared with IVUS-VH parameters assessing the extent and composition of coronary atherosclerosis. ResultsA total of 36 coronary patients (99 vessels) comprised the study population. From the 23 geometric indexes, 18 parameters were significantly (p < 0.05) associated with at least 1 IVUS-VH parameter at a univariate analysis. All three main geometric categories provided parameters significantly related with atherosclerosis variables. The 3D geometric indexes were associated with the degree of atherosclerotic extension, as well as with plaque composition. Geometric features remained significantly associated with all IVUS-VH parameters even after multivariate adjustment for clinical characteristics. ConclusionsQuantitative 3D vessel morphology emerges as a relevant factor associated with atherosclerosis in patients with established CAD.

Quantitative coronary three‐dimensional geometry and its association with atherosclerotic disease burden and composition / Prado, Guy F. A.; Blanco, Pablo J.; Bulant, Carlos A.; Ares, Gonzalo D.; Mariani, Jose; Caixeta, Adriano; Almeida, Breno O.; Garzon, Stefano; Pinton, Fábio A.; Barbato, Emanuele; Ribichini, Flavio L.; Toth, Gabor G.; Mahfoud, Felix; Wijns, William; Garcia‐garcia, Hector M.; Lemos, Pedro A.. - In: CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. - ISSN 1522-1946. - 101:6(2023), pp. 1036-1044. [10.1002/ccd.30639]

Quantitative coronary three‐dimensional geometry and its association with atherosclerotic disease burden and composition

Prado, Guy F. A.
Primo
;
Barbato, Emanuele;
2023

Abstract

BackgroundIsolate features of the coronary anatomy have been associated with the pathophysiology of atherosclerotic disease. Computational methods have been described to allow precise quantification of the complex three-dimensional (3D) coronary geometry. The present study tested whether quantitative parameters that describe the spatial 3D coronary geometry is associated with the extension and composition of the underlying coronary artery disease (CAD). MethodsPatients with CAD scheduled for percutaneous intervention were investigated with coronary computed tomography angiography (CCTA), and invasive coronary angiography, and virtual histology intravascular ultrasound (IVUS-VH). For all target vessels, 3D centerlines were extracted from CCTA images and processed to quantify 23 geometric indexes, grouped into 3 main categories as follows: (i) length-based; (ii) curvature-based, torsion-based, and curvature/torsion-combined; (iii) vessel path-based. The geometric variables were compared with IVUS-VH parameters assessing the extent and composition of coronary atherosclerosis. ResultsA total of 36 coronary patients (99 vessels) comprised the study population. From the 23 geometric indexes, 18 parameters were significantly (p < 0.05) associated with at least 1 IVUS-VH parameter at a univariate analysis. All three main geometric categories provided parameters significantly related with atherosclerosis variables. The 3D geometric indexes were associated with the degree of atherosclerotic extension, as well as with plaque composition. Geometric features remained significantly associated with all IVUS-VH parameters even after multivariate adjustment for clinical characteristics. ConclusionsQuantitative 3D vessel morphology emerges as a relevant factor associated with atherosclerosis in patients with established CAD.
2023
coronary artery disease; coronary computed tomography angiography; coronary geometry; geometric risk factors; intravascular ultrasound
01 Pubblicazione su rivista::01a Articolo in rivista
Quantitative coronary three‐dimensional geometry and its association with atherosclerotic disease burden and composition / Prado, Guy F. A.; Blanco, Pablo J.; Bulant, Carlos A.; Ares, Gonzalo D.; Mariani, Jose; Caixeta, Adriano; Almeida, Breno O.; Garzon, Stefano; Pinton, Fábio A.; Barbato, Emanuele; Ribichini, Flavio L.; Toth, Gabor G.; Mahfoud, Felix; Wijns, William; Garcia‐garcia, Hector M.; Lemos, Pedro A.. - In: CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. - ISSN 1522-1946. - 101:6(2023), pp. 1036-1044. [10.1002/ccd.30639]
File allegati a questo prodotto
File Dimensione Formato  
Prado_Quantitative-coronary_2023.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.34 MB
Formato Adobe PDF
1.34 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1716291
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact