Ageing has been defined as a specific individual plasticity and remodeling capacity to the environment’ insults and stimuli. The precise physiology of aging is not entirely understood. Several theories have been proposed and included programmed cell death, genetic mutations, the epigenetic clock, wear-and-tear and free radicals. Ocular surface represents a complex morpho-functional unit composed of different tissues that strictly interact to pre- serve homeostasis and function. Ageing severely disrupts this system by means of inflammaging and immuno- senescence, leading to ocular surface failure in older population.
Age-related ocular surface failure: A narrative review / Di Zazzo, Antonio; Coassin, Marco; Surico, PIER LUIGI; Bonini, Stefano. - In: EXPERIMENTAL EYE RESEARCH. - ISSN 0014-4835. - (2022). [10.1016/j.exer.2022.109035]
Age-related ocular surface failure: A narrative review
Pier Luigi Surico;Stefano Bonini
2022
Abstract
Ageing has been defined as a specific individual plasticity and remodeling capacity to the environment’ insults and stimuli. The precise physiology of aging is not entirely understood. Several theories have been proposed and included programmed cell death, genetic mutations, the epigenetic clock, wear-and-tear and free radicals. Ocular surface represents a complex morpho-functional unit composed of different tissues that strictly interact to pre- serve homeostasis and function. Ageing severely disrupts this system by means of inflammaging and immuno- senescence, leading to ocular surface failure in older population.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
