Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto-protection. This review summarizes the current knowledge of both the physiological and pathological roles of α-MSH and its receptors in the eye. We focus on recent developments in the biology of α-MSH and the relevant clinical implications in treating ocular diseases.
Therapeutic effects of stimulating the melanocortin pathway in regulating ocular inflammation and cell death / Wang, Shudan; Kahale, Francesca; Naderi, Amirreza; Surico, PIER LUIGI; Yin, Jia; Dohlman, Thomas; Chen, Yihe; Dana, Reza. - In: BIOMOLECULES. - ISSN 2218-273X. - 14:2(2024), pp. 1-16. [10.3390/biom14020169]
Therapeutic effects of stimulating the melanocortin pathway in regulating ocular inflammation and cell death
Pier Luigi SuricoConceptualization
;
2024
Abstract
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto-protection. This review summarizes the current knowledge of both the physiological and pathological roles of α-MSH and its receptors in the eye. We focus on recent developments in the biology of α-MSH and the relevant clinical implications in treating ocular diseases.| File | Dimensione | Formato | |
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