Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy that relies on highly heterogeneous cytogenetic alterations. Although in the last few years new agents have been developed for AML treatment, the overall survival prospects for AML patients are still gloomy and new therapeutic options are still urgently needed. Constitutive NF-kappa B activation has been reported in around 40% of AML patients, where it sustains AML cell survival and chemoresistance. Given the central role of NF-kappa B in AML, targeting the NF-kappa B pathway represents an attractive strategy to treat AML. This review focuses on current knowledge of NF-kappa B's roles in AML pathogenesis and summarizes the main therapeutic approaches used to treat NF-kappa B-driven AML.
NF-κB: A Druggable Target in Acute Myeloid Leukemia / Di Francesco, Barbara; Verzella, Daniela; Capece, Daria; Vecchiotti, Davide; Di Vito Nolfi, Mauro; Flati, Irene; Cornice, Jessica; Di Padova, Monica; Angelucci, Adriano; Alesse, Edoardo; Zazzeroni, Francesca. - In: CANCERS. - ISSN 2072-6694. - 14:14(2022), p. 3557. [10.3390/cancers14143557]
NF-κB: A Druggable Target in Acute Myeloid Leukemia
Flati, Irene;
2022
Abstract
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy that relies on highly heterogeneous cytogenetic alterations. Although in the last few years new agents have been developed for AML treatment, the overall survival prospects for AML patients are still gloomy and new therapeutic options are still urgently needed. Constitutive NF-kappa B activation has been reported in around 40% of AML patients, where it sustains AML cell survival and chemoresistance. Given the central role of NF-kappa B in AML, targeting the NF-kappa B pathway represents an attractive strategy to treat AML. This review focuses on current knowledge of NF-kappa B's roles in AML pathogenesis and summarizes the main therapeutic approaches used to treat NF-kappa B-driven AML.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
