: Secondary primary malignancies (SPM) have been reported after anti-BCMA or anti-CD19 chimeric antigen receptor (CAR)-T-cell therapies. While the cytotoxic effect of antecedent therapies, including chemotherapy and radiotherapy, has been well established, few data are available on risk related to CAR-T immunotherapies. The study aimed to analyse the incidence of SPM in 651 patients enrolled in the Italian prospective observational CART-SIE study. SPMs were documented in 4.3% (28/651), and the most frequent SPMs were haematological malignancies. In conclusion, the frequency of SPMs in our cohort of heavily pretreated patients receiving CAR-T was relatively low and consistent with previous studies.
Secondary primary malignancies after CD-19 directed CAR-T-cell therapy in lymphomas: A report from the Italian CART-SIE study / Barone, Angelica; Chiappella, Annalisa; Casadei, Beatrice; Bramanti, Stefania; Ljevar, Silva; Chiusolo, Patrizia; Di Rocco, Alice; Tisi, Maria Chiara; Barbui, Anna Maria; Farina, Mirko; Brunello, Lucia; Di Chio, Maria Chiara; Novo, Mattia; Musso, Maurizio; Olivieri, Jacopo; Trotta, Gentiana Elena; Dodero, Anna; Aiello, Antonella; Corradini, Paolo. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 1365-2141. - (2024). [10.1111/bjh.19590]
Secondary primary malignancies after CD-19 directed CAR-T-cell therapy in lymphomas: A report from the Italian CART-SIE study
Di Rocco, Alice;
2024
Abstract
: Secondary primary malignancies (SPM) have been reported after anti-BCMA or anti-CD19 chimeric antigen receptor (CAR)-T-cell therapies. While the cytotoxic effect of antecedent therapies, including chemotherapy and radiotherapy, has been well established, few data are available on risk related to CAR-T immunotherapies. The study aimed to analyse the incidence of SPM in 651 patients enrolled in the Italian prospective observational CART-SIE study. SPMs were documented in 4.3% (28/651), and the most frequent SPMs were haematological malignancies. In conclusion, the frequency of SPMs in our cohort of heavily pretreated patients receiving CAR-T was relatively low and consistent with previous studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
