Addressing the context, the system reliability analysis for APHRODITE mission have been done in order to ensure its functionality for the autonomous and real-time analysis on board the ISS. Moreover, this paper emphasizes the magnet complex actuation subsystem in the system overview section. APHRODITE core system consists of a lab-on-chip (LoC) with integrated thin-film sensors in hydrogenated amorphous silicon (a-Si:H) able to host dual-analytes competitive chemiluminescence (CL) immunoassay. APHRODITE’s design allows for ultra- sensitive quantification of these target biomarkers present in sub-molar quantities, using a non- invasive approach. The core technical innovation of APHRODITE lies in functionalized magnetic microbeads that enable parallel multi-analyte tests and multiple subsequent runs on different samples upon a inline washing protocol. This design leverages immunoassays, making it ideal for detecting analytes in small volumes of complex matrices, even at low concentration.

Advancing In-Flight Medical Diagnostics: The APHRODITE Lab-On-Chip System for Biomarker Analysis Abroad the International Space Station / Abbasrezaee, P.; MAIPAN DAVIS, Nithin; Nardi, Lorenzo; De Albuquerque, T.; Caputo, Domenico; Lovecchio, Nicola; Shariati Pour, R.; Zangheri, M.; Emamiamin (3), A.; Calabria, D.; Guardigli, M.; Balsamo, M.; Carrubba, E.; Tenaglia, A.; Ghiozzi, M.; Ceccarelli, M.; Popova, L.; Tenaglia, A.; Crisconio, M.; Donati, A.; Nascetti, Augusto; Mirasoli, Mara. - (2024). (Intervento presentato al convegno The 4S Symposium 2024 tenutosi a Palma de Mallorca (Spain)).

Advancing In-Flight Medical Diagnostics: The APHRODITE Lab-On-Chip System for Biomarker Analysis Abroad the International Space Station.

P. Abbasrezaee
;
Nithin Maipan Davis;Lorenzo Nardi;Domenico Caputo;Nicola Lovecchio;Augusto Nascetti;
2024

Abstract

Addressing the context, the system reliability analysis for APHRODITE mission have been done in order to ensure its functionality for the autonomous and real-time analysis on board the ISS. Moreover, this paper emphasizes the magnet complex actuation subsystem in the system overview section. APHRODITE core system consists of a lab-on-chip (LoC) with integrated thin-film sensors in hydrogenated amorphous silicon (a-Si:H) able to host dual-analytes competitive chemiluminescence (CL) immunoassay. APHRODITE’s design allows for ultra- sensitive quantification of these target biomarkers present in sub-molar quantities, using a non- invasive approach. The core technical innovation of APHRODITE lies in functionalized magnetic microbeads that enable parallel multi-analyte tests and multiple subsequent runs on different samples upon a inline washing protocol. This design leverages immunoassays, making it ideal for detecting analytes in small volumes of complex matrices, even at low concentration.
2024
The 4S Symposium 2024
lab-on-chip; chemiluminescence; hydrogenated amorphous silicon photosensors; biosensor; International Space Station.
04 Pubblicazione in atti di convegno::04b Atto di convegno in volume
Advancing In-Flight Medical Diagnostics: The APHRODITE Lab-On-Chip System for Biomarker Analysis Abroad the International Space Station / Abbasrezaee, P.; MAIPAN DAVIS, Nithin; Nardi, Lorenzo; De Albuquerque, T.; Caputo, Domenico; Lovecchio, Nicola; Shariati Pour, R.; Zangheri, M.; Emamiamin (3), A.; Calabria, D.; Guardigli, M.; Balsamo, M.; Carrubba, E.; Tenaglia, A.; Ghiozzi, M.; Ceccarelli, M.; Popova, L.; Tenaglia, A.; Crisconio, M.; Donati, A.; Nascetti, Augusto; Mirasoli, Mara. - (2024). (Intervento presentato al convegno The 4S Symposium 2024 tenutosi a Palma de Mallorca (Spain)).
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1710899
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact