2’3’-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) is the endogenous agonist of STING; as such, cGAMP has powerful immunostimulatory activity, due to its capacity to stimulate type I interferon-mediated immunity. Recent evidence indicates that cancer cells, under certain conditions, can release cGAMP extracellularly, a phenomenon currently considered important for therapeutic responses and tumor rejection. Nonetheless, the mechanisms that regulate cGAMP activity in the extracellular environment are still largely unexplored. In this work, we collected evidence demonstrating that CD38 glycohydrolase can inhibit extracellular cGAMP activity through its direct binding.

CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma / Cuollo, Lorenzo; DI CRISTOFANO, Samuele; Sandomenico, Annamaria; Iaccarino, Emanuela; Oliver, Angela; Zingoni, Alessandra; Cippitelli, Marco; Fionda, Cinzia; Petillo, Sara; Kosta, Andrea; Tassinari, Valentina; Petrucci, MARIA TERESA; Fazio, Francesca; Menotti, Ruvo; Santoni, Angela; Raimondo, Domenico; Soriani, Alessandra. - In: ISCIENCE. - ISSN 2589-0042. - 27:5(2024). [10.1016/j.isci.2024.109814]

CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma

Lorenzo Cuollo
Co-primo
;
Samuele Di Cristofano
Co-primo
;
Alessandra Zingoni;Marco Cippitelli;Cinzia Fionda;Sara Petillo;Andrea Kosta;Valentina Tassinari;Maria Teresa Petrucci;Angela Santoni;Domenico Raimondo
;
Alessandra Soriani
Ultimo
2024

Abstract

2’3’-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) is the endogenous agonist of STING; as such, cGAMP has powerful immunostimulatory activity, due to its capacity to stimulate type I interferon-mediated immunity. Recent evidence indicates that cancer cells, under certain conditions, can release cGAMP extracellularly, a phenomenon currently considered important for therapeutic responses and tumor rejection. Nonetheless, the mechanisms that regulate cGAMP activity in the extracellular environment are still largely unexplored. In this work, we collected evidence demonstrating that CD38 glycohydrolase can inhibit extracellular cGAMP activity through its direct binding.
2024
cGAMP, CD38, Myeloma
01 Pubblicazione su rivista::01a Articolo in rivista
CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma / Cuollo, Lorenzo; DI CRISTOFANO, Samuele; Sandomenico, Annamaria; Iaccarino, Emanuela; Oliver, Angela; Zingoni, Alessandra; Cippitelli, Marco; Fionda, Cinzia; Petillo, Sara; Kosta, Andrea; Tassinari, Valentina; Petrucci, MARIA TERESA; Fazio, Francesca; Menotti, Ruvo; Santoni, Angela; Raimondo, Domenico; Soriani, Alessandra. - In: ISCIENCE. - ISSN 2589-0042. - 27:5(2024). [10.1016/j.isci.2024.109814]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1709853
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