Background: Following the pandemic restrictions, the epidemiology of respiratory syncytial virus (RSV) has changed, leading to intense hospitalization peaks. Objectives: This study, conducted at multiple sites in Italy, aimed to describe the temporal dynamics of two post-COVID-19 RSV epidemics. Additionally, the circulating RSV-A and -B lineages were characterized and compared to those found in 2018 and 2019. Study design: Respiratory specimens and data were collected from RSV-positive patients, both inpatients, and outpatients, of all ages at three sites in north-central Italy. To analyze these samples, roughly one-sixth were sequenced in the attachment glycoprotein G gene and subjected to phylogenetic and mutational analyses, including pre-pandemic sequences from north-central Italy. Results: The first post-pandemic surge of RSV cases was quite intense, occurring from October 2021 to early January 2022. The subsequent RSV epidemic (from November 2022 to early March 2023) also had a high impact, characterized by a rise in elderly patient cases. Post-pandemic cases of RSV-A were caused by various strains present in Italy prior to COVID-19. In contrast, a distinct RSV-B lineage, which was concurrently spreading in other countries, was identified as the main cause of the surge in 2022-2023 but remained undetected in Italy before the pandemic. Conclusions: This study describes the temporal dynamics of post-pandemic RSV subgroups and uncovers a lineage of RSV-B with high genetic divergence that may have increased the impact of decreased population immunity.

Sequence analysis of respiratory syncytial virus cases reveals a novel subgroup -B strain circulating in north-central Italy after pandemic restrictions / Pierangeli, Alessandra; Midulla, Fabio; Piralla, Antonio; Ferrari, Guglielmo; Nenna, Raffaella; Pitrolo, Antonino Maria Guglielmo; Licari, Amelia; Marseglia, Gian Luigi; Abruzzese, Dario; Pellegrinelli, Laura; Galli, Cristina; Binda, Sandro; Cereda, Danilo; Fracella, Matteo; Oliveto, Giuseppe; Campagna, Roberta; Petrarca, Laura; Pariani, Elena; Antonelli, Guido; Baldanti, Fausto. - In: JOURNAL OF CLINICAL VIROLOGY. - ISSN 1873-5967. - 173:(2024). [10.1016/j.jcv.2024.105681]

Sequence analysis of respiratory syncytial virus cases reveals a novel subgroup -B strain circulating in north-central Italy after pandemic restrictions

Pierangeli, Alessandra
Primo
;
Midulla, Fabio
Secondo
;
Nenna, Raffaella;Galli, Cristina;Fracella, Matteo;Oliveto, Giuseppe;Campagna, Roberta;Petrarca, Laura;Antonelli, Guido
Ultimo
;
2024

Abstract

Background: Following the pandemic restrictions, the epidemiology of respiratory syncytial virus (RSV) has changed, leading to intense hospitalization peaks. Objectives: This study, conducted at multiple sites in Italy, aimed to describe the temporal dynamics of two post-COVID-19 RSV epidemics. Additionally, the circulating RSV-A and -B lineages were characterized and compared to those found in 2018 and 2019. Study design: Respiratory specimens and data were collected from RSV-positive patients, both inpatients, and outpatients, of all ages at three sites in north-central Italy. To analyze these samples, roughly one-sixth were sequenced in the attachment glycoprotein G gene and subjected to phylogenetic and mutational analyses, including pre-pandemic sequences from north-central Italy. Results: The first post-pandemic surge of RSV cases was quite intense, occurring from October 2021 to early January 2022. The subsequent RSV epidemic (from November 2022 to early March 2023) also had a high impact, characterized by a rise in elderly patient cases. Post-pandemic cases of RSV-A were caused by various strains present in Italy prior to COVID-19. In contrast, a distinct RSV-B lineage, which was concurrently spreading in other countries, was identified as the main cause of the surge in 2022-2023 but remained undetected in Italy before the pandemic. Conclusions: This study describes the temporal dynamics of post-pandemic RSV subgroups and uncovers a lineage of RSV-B with high genetic divergence that may have increased the impact of decreased population immunity.
2024
Genetic diversity; Genotype; Molecular epidemiology; Pandemic restrictions; RSV-B; Respiratory syncytial virus
01 Pubblicazione su rivista::01a Articolo in rivista
Sequence analysis of respiratory syncytial virus cases reveals a novel subgroup -B strain circulating in north-central Italy after pandemic restrictions / Pierangeli, Alessandra; Midulla, Fabio; Piralla, Antonio; Ferrari, Guglielmo; Nenna, Raffaella; Pitrolo, Antonino Maria Guglielmo; Licari, Amelia; Marseglia, Gian Luigi; Abruzzese, Dario; Pellegrinelli, Laura; Galli, Cristina; Binda, Sandro; Cereda, Danilo; Fracella, Matteo; Oliveto, Giuseppe; Campagna, Roberta; Petrarca, Laura; Pariani, Elena; Antonelli, Guido; Baldanti, Fausto. - In: JOURNAL OF CLINICAL VIROLOGY. - ISSN 1873-5967. - 173:(2024). [10.1016/j.jcv.2024.105681]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1709780
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