Background: Olfactory dysfunction is a well-known phenomenon in neurological diseases with anosmia and hyposmia serving as clinical or preclinical indicators of Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative disorders. Since glaucoma is a neurodegenerative disease of the visual system, it may also entail alterations in olfactory function, warranting investigation into potential sensory interconnections. Methods: A review of the current literature of the last 15 years (from 1 April 2008 to 1 April 2023) was conducted by two different authors searching for topics related to olfaction and glaucoma. Results: three papers met the selection criteria. According to these findings, patients with POAG appear to have worse olfaction than healthy subjects. Furthermore, certain predisposing conditions to glaucoma, such as pseudoexfoliation syndrome and primary vascular dysregulation, could possibly induce olfactory changes that can be measured with the Sniffin Stick test. Conclusions: the scientific literature on this topic is very limited, and the pathogenesis of olfactory changes in glaucoma is not clear. However, if the results of these studies are confirmed by further research, olfactory testing may be a non-invasive tool to assist clinicians in the early diagnosis of glaucoma.

Olfactory dysfunction and glaucoma / Iannucci, Valeria; Bruscolini, Alice; Iannella, Giannicola; Visioli, Giacomo; Alisi, Ludovico; Salducci, Mauro; Greco, Antonio; Lambiase, Alessandro. - In: BIOMEDICINES. - ISSN 2227-9059. - 12:5(2024), pp. 1-12. [10.3390/biomedicines12051002]

Olfactory dysfunction and glaucoma

Iannucci Valeria
Primo
Conceptualization
;
Bruscolini Alice
Secondo
Writing – Review & Editing
;
Iannella Giannicola
Writing – Original Draft Preparation
;
Visioli Giacomo
Writing – Review & Editing
;
Alisi Ludovico
Writing – Review & Editing
;
Salducci Mauro
Writing – Original Draft Preparation
;
Greco Antonio
Penultimo
Writing – Review & Editing
;
Lambiase Alessandro
Ultimo
Supervision
2024

Abstract

Background: Olfactory dysfunction is a well-known phenomenon in neurological diseases with anosmia and hyposmia serving as clinical or preclinical indicators of Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative disorders. Since glaucoma is a neurodegenerative disease of the visual system, it may also entail alterations in olfactory function, warranting investigation into potential sensory interconnections. Methods: A review of the current literature of the last 15 years (from 1 April 2008 to 1 April 2023) was conducted by two different authors searching for topics related to olfaction and glaucoma. Results: three papers met the selection criteria. According to these findings, patients with POAG appear to have worse olfaction than healthy subjects. Furthermore, certain predisposing conditions to glaucoma, such as pseudoexfoliation syndrome and primary vascular dysregulation, could possibly induce olfactory changes that can be measured with the Sniffin Stick test. Conclusions: the scientific literature on this topic is very limited, and the pathogenesis of olfactory changes in glaucoma is not clear. However, if the results of these studies are confirmed by further research, olfactory testing may be a non-invasive tool to assist clinicians in the early diagnosis of glaucoma.
2024
smell; olfaction; olfactory test; hyposmia; neurodegeneration; glaucoma; retinal ganglion cells; pseudoexfoliation syndrome; olfactory dysfunction; olfactory disorders
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Olfactory dysfunction and glaucoma / Iannucci, Valeria; Bruscolini, Alice; Iannella, Giannicola; Visioli, Giacomo; Alisi, Ludovico; Salducci, Mauro; Greco, Antonio; Lambiase, Alessandro. - In: BIOMEDICINES. - ISSN 2227-9059. - 12:5(2024), pp. 1-12. [10.3390/biomedicines12051002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1709438
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