The Corynebacterium diphtheriae species complex comprises seven bacterial species, including Corynebacterium ulcerans, a zoonotic pathogen from multiple animal species. In this work, we characterise phenotypically and genotypically isolates belonging to two C. ulcerans lineages. Results from phylogenetic analyses, in silico DNA–DNA hybridization (DDH) and MALDI-TOF spectra differentiate lineage 2 from C. ulcerans lineage 1, which, together with their distinct transmission dynamics (probable human-to-human vs animal-to-human), indicates that lineage 2 is a separate Corynebacterium species, which we propose to name Corynebacterium ramonii. This species is of particular medical interest considering that its human-to-human transmission is likely, and that some C. ramonii isolates carry the diphtheria toxin gene.
Corynebacterium ramonii sp. nov., a novel toxigenic member of the Corynebacterium diphtheriae species complex / Crestani, Chiara; Arcari, Gabriele; Landier, Annie; Passet, Virginie; Garnier, Dorian; Brémont, Sylvie; Armatys, Nathalie; Carmi-Leroy, Annick; Toubiana, Julie; Badell, Edgar; Brisse, Sylvain. - In: RESEARCH IN MICROBIOLOGY. - ISSN 0923-2508. - 174:7(2023). [10.1016/j.resmic.2023.104113]
Corynebacterium ramonii sp. nov., a novel toxigenic member of the Corynebacterium diphtheriae species complex
Arcari, Gabriele;
2023
Abstract
The Corynebacterium diphtheriae species complex comprises seven bacterial species, including Corynebacterium ulcerans, a zoonotic pathogen from multiple animal species. In this work, we characterise phenotypically and genotypically isolates belonging to two C. ulcerans lineages. Results from phylogenetic analyses, in silico DNA–DNA hybridization (DDH) and MALDI-TOF spectra differentiate lineage 2 from C. ulcerans lineage 1, which, together with their distinct transmission dynamics (probable human-to-human vs animal-to-human), indicates that lineage 2 is a separate Corynebacterium species, which we propose to name Corynebacterium ramonii. This species is of particular medical interest considering that its human-to-human transmission is likely, and that some C. ramonii isolates carry the diphtheria toxin gene.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
