Organ-on-a-chip (OoCs) platforms could revolutionize drug discovery and might ultimately become essential tools for precision therapy. Although many single-organ and interconnected systems have been described, the immune system has been comparatively neglected, despite its pervasive role in the body and the trend towards newer therapeutic products (i.e., complex biologics, nanoparticles, immune checkpoint inhibitors, and engineered T cells) that often cause, or are based on, immune reactions. In this review, we recapitulate some distinctive features of the immune system before reviewing microfluidic devices that mimic lymphoid organs or other organs and/or tissues with an integrated immune system component.

Towards the development of human Immune System-on-a-chip platform / Polini, Alessandro; del Mercato, Loretta L.; Barra, Adriano; Shrike Zhang, Yu; Calabi, Franco; Gigli, Giuseppe. - In: DRUG DISCOVERY TODAY. - ISSN 1878-5832. - 24:2(2019), pp. 517-525. [10.1016/j.drudis.2018.10.003]

Towards the development of human Immune System-on-a-chip platform

Adriano Barra;
2019

Abstract

Organ-on-a-chip (OoCs) platforms could revolutionize drug discovery and might ultimately become essential tools for precision therapy. Although many single-organ and interconnected systems have been described, the immune system has been comparatively neglected, despite its pervasive role in the body and the trend towards newer therapeutic products (i.e., complex biologics, nanoparticles, immune checkpoint inhibitors, and engineered T cells) that often cause, or are based on, immune reactions. In this review, we recapitulate some distinctive features of the immune system before reviewing microfluidic devices that mimic lymphoid organs or other organs and/or tissues with an integrated immune system component.
2019
lab on chip; immune networks; control in complex networks; emergent behavior
01 Pubblicazione su rivista::01a Articolo in rivista
Towards the development of human Immune System-on-a-chip platform / Polini, Alessandro; del Mercato, Loretta L.; Barra, Adriano; Shrike Zhang, Yu; Calabi, Franco; Gigli, Giuseppe. - In: DRUG DISCOVERY TODAY. - ISSN 1878-5832. - 24:2(2019), pp. 517-525. [10.1016/j.drudis.2018.10.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1707786
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