Purpose To validate the use, repeatability, and reproducibility of a new, cost-effective, disposable, sterile device (KeraSenseⓇ, Dompè farmaceutici SpA, Milan Italy) compared to Cochet-Bonnet (CB) esthesiometer. Secondly, to identify a simple, safe, rapid, and low-cost test to diagnose neurotrophic keratitis (NK). Methods 16 patients with diagnosis of NK stage I, 25 patients with diabetes mellitus (DM), and 26 healthy subjects were included in the study. Corneal sensitivity (CS) was assessed by CB and KeraSenseⓇ. Repeatability, accuracy, and reproducibility of the novel disposable aesthesiometer were assessed. Specificity, sensitivity, and cut-off value for NK diagnosis were calculated by ROC curve analysis. Results All NK patients showed a CS ≤ 40 mm, while none of the healthy patients showed a CS value < 50 mm. Significant agreement was found between CB measurements and the single use esthesiometer evaluations of CS (p < 0.001). Repeatability evaluations of the single use esthesiometer showed 100% agreement between different measurements (p < 0.001). Reproducibility evaluations showed 99.6% concordance between different operators (p < 0.001). A 55 mm value of the single use esthesiometer was adequate to exclude an NK diagnosis, while all NK patients showed a value ≤ 35 mm. Conclusions Corneal hypo/anaesthesia is considered the hallmark of NK. The use of the novel single-use esthesiometer will allow for a diagnostic improvement in NK, sparing time and guaranteeing patients’ safety. Diabetic patients despite normal corneal findings may show impairment of CS, suggesting a preclinical stage of NK, requiring a close follow-up.

New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis / Giovannetti, Francesca; Sacchetti, Marta; Marenco, Marco; Alisi, Ludovico; Visioli, Giacomo; Bruscolini, Alice; Lambiase, Alessandro. - In: THE OCULAR SURFACE. - ISSN 1542-0124. - 32:(2024), pp. 192-197. [10.1016/j.jtos.2024.03.009]

New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis

Giovannetti, Francesca
Primo
Writing – Original Draft Preparation
;
Sacchetti, Marta
Secondo
Methodology
;
Marenco, Marco
Investigation
;
Alisi, Ludovico
Writing – Review & Editing
;
Visioli, Giacomo
Formal Analysis
;
Bruscolini, Alice
Penultimo
Visualization
;
Lambiase, Alessandro
Ultimo
Supervision
2024

Abstract

Purpose To validate the use, repeatability, and reproducibility of a new, cost-effective, disposable, sterile device (KeraSenseⓇ, Dompè farmaceutici SpA, Milan Italy) compared to Cochet-Bonnet (CB) esthesiometer. Secondly, to identify a simple, safe, rapid, and low-cost test to diagnose neurotrophic keratitis (NK). Methods 16 patients with diagnosis of NK stage I, 25 patients with diabetes mellitus (DM), and 26 healthy subjects were included in the study. Corneal sensitivity (CS) was assessed by CB and KeraSenseⓇ. Repeatability, accuracy, and reproducibility of the novel disposable aesthesiometer were assessed. Specificity, sensitivity, and cut-off value for NK diagnosis were calculated by ROC curve analysis. Results All NK patients showed a CS ≤ 40 mm, while none of the healthy patients showed a CS value < 50 mm. Significant agreement was found between CB measurements and the single use esthesiometer evaluations of CS (p < 0.001). Repeatability evaluations of the single use esthesiometer showed 100% agreement between different measurements (p < 0.001). Reproducibility evaluations showed 99.6% concordance between different operators (p < 0.001). A 55 mm value of the single use esthesiometer was adequate to exclude an NK diagnosis, while all NK patients showed a value ≤ 35 mm. Conclusions Corneal hypo/anaesthesia is considered the hallmark of NK. The use of the novel single-use esthesiometer will allow for a diagnostic improvement in NK, sparing time and guaranteeing patients’ safety. Diabetic patients despite normal corneal findings may show impairment of CS, suggesting a preclinical stage of NK, requiring a close follow-up.
2024
Cochet-Bonnet esthesiometer; corneal nerve; corneal sensitivity; diabetes mellitus; esthesiometry; neurotrophic keratitis; ocular surface
01 Pubblicazione su rivista::01a Articolo in rivista
New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis / Giovannetti, Francesca; Sacchetti, Marta; Marenco, Marco; Alisi, Ludovico; Visioli, Giacomo; Bruscolini, Alice; Lambiase, Alessandro. - In: THE OCULAR SURFACE. - ISSN 1542-0124. - 32:(2024), pp. 192-197. [10.1016/j.jtos.2024.03.009]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1706877
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