INTRODUCTION:We assessed the impact of long-term albumin administration to hyponatremic patients with ascites enrolled in the ANSWER trial.METHODS:The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated.RESULTS:The hyponatremia normalization rate was higher with albumin than with standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167-0.359], P < 0.001).DISCUSSION:Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites.
Correction and Prevention of Hyponatremia in Patients With Cirrhosis and Ascites: Post Hoc Analysis of the ANSWER Study Database / Zaccherini, Giacomo; Baldassarre, Maurizio; Tufoni, Manuel; Nardelli, Silvia; Piano, Salvatore; Alessandria, Carlo; Neri, Sergio; Foschi, Francesco Giuseppe; Levantesi, Fabio; Bedogni, Giorgio; Domenicali, Marco; Bernardi, Mauro; Caraceni, Paolo; Null, Null. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 118:1(2023), pp. 168-173. [10.14309/ajg.0000000000001995]
Correction and Prevention of Hyponatremia in Patients With Cirrhosis and Ascites: Post Hoc Analysis of the ANSWER Study Database
Nardelli, Silvia;Bernardi, Mauro;
2023
Abstract
INTRODUCTION:We assessed the impact of long-term albumin administration to hyponatremic patients with ascites enrolled in the ANSWER trial.METHODS:The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated.RESULTS:The hyponatremia normalization rate was higher with albumin than with standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167-0.359], P < 0.001).DISCUSSION:Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
