The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990).

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study / Podda, Mauro; Pellino, Gianluca; Di Saverio, Salomone; Coccolini, Federico; Pacella, Daniela; Cioffi, Stefano Piero Bernardo; Virdis, Francesco; Balla, Andrea; Ielpo, Benedetto; Pata, Francesco; Poillucci, Gaetano; Ortenzi, Monica; Damaskos, Dimitrios; De Simone, Belinda; Sartelli, Massimo; Leppaniemi, Ari; Jayant, Kumar; Catena, Fausto; Giuliani, Antonio; Di Martino, Marcello; Pisanu, Adolfo; Gerardi, Chiara; Gourgiotis, Stavros; Riboni, Cristiana; Giordano, Alessio; Ferrario, Luca; Agnoletti, Vanni; Kruger, Yoram; Mole, Damian; Agresta, Ferdinando; Prieto Calvo, Mikel; Wilson, Michael; Soggiu, Fiammetta; Hamdan, Alaa; Gomes, Carlos Augusto; Fraga, Gustavo; Ioannidis, Argyrios; Demetrashvili, Zaza; Sahani, Saaz; Bains, Lovenish; Khamees, Almu’Atasim; Ababneh, Hazim; Aljaiuossi, Osama; Pimentel, Samuel; Mohamad, Ikhwan Sani; Yusoff, Ahmad Ramzi; Zarnescu, Narcis Octavian; Calu, Valentin; Litvin, Andrey; Lesko, Dusan; Elmehrath, Ahmed; Elshami, Mohamedraed; de Santibañes, Martin; Gundara, Justin; Alawadhi, Kamel; Lui, Rashid; Julianov, Alexander; Ralon, Sergio; Garzali, Ibrahim-Umar; Machain, Gustavo M; Villalabeitia, Ibabe; Quispe-Cruz, Darwin Artidoro; Orantia, Abigail Cheska C.; Walędziak, Maciej; de Sá, Tiago Correia; Ali, Syed Muhammad; Kovacevic, Bojan; Noel, Colin; Abdalah, Haidar M.; Kchaou, Ali; Isik, Arda; Ansaloni, Luca; Biffl, Walter; Guerrieri, Mario; Sartori, Alberto; Abradelo, Manuel; Nigri, Giuseppe; Di Lorenzo, Nicola; Mingoli, Andrea; Chiarugi, Massimo; Di Menno Stavron, Juliana; Mazza, Oscar; Valenzuela, José Ignacio; Pachajoa, Diana Alejandra Pantoja; Alvarez, Fernando Andrés; Liaño, Julian Ezequiel; Tefay, Joan; Alshaikh, Abdulrahman; Hasan, Layla; Couto Gomes, Felipe; Calderan, Thiago R. A.; Hirano, Elcio S.; Dardanov, Dragomir; Julianov, Alexander; Saroglu, Azize; Atanasov, Boyko; Belev, Nikolay; Kovachev, Nikola; Chan, Shannon Melissa; Lok, Hon-Ting; Salcedo, Diego; Robayo, Diana; Triviño, María Alejandra; Manak, Jan; Sahani, Saaz; de Araujo, Jorann; Sethi, Ananya; Awad, Ahmed; Elbadawy, Merihan; Farid, Ahmed; Hanafy, Asmaa; Nafea, Ahmed; Sherief, Ghozy; Salah Alzhraa, Abbas; Abdelsalam, Wafaa; Emile, Sameh; Elfallal, Ahmed; Elfeki, Hossam; Elghadban, Hosam; Shoma, Ashraf; Shetiwy, Mohamed; Elbahnasawy, Mohamed; Mohamed, Salem; Hamed, Emad Fawzi; Khalil, Usama Ahmed; Chouillard, Elie; Gumbs, Andrew; Police, Andrea; Mabilia, Andrea; Khutsishvili, Kakhi; Tvaladze, Anano; Ioannidis, Orestis; Anestiadou, Elissavet; Loutzidou, Lydia; Konstantinidis, Konstantinis; Konstantinidou, Sofia; Manatakis, Dimitrios; Acheimastos, Vasileios; Tasis, Nikolaos; Michalopoulos, Nikolaos; Kokoropoulos, Panagiotis; Papadoliopoulou, Maria; Sotiropoulou, Maria; Kapiris, Stylianos; Metaxas, Panagiotis; Tsouknidas, Ioannis; Kefili, Despoina; Petrakis, George; Synekidou, Eirini; Dakis, Konstantinos; Alexandridou, Eirini; Papadopoulos, Aristeidis; Chouliaras, Christos; Mouzakis, Odysseas; Mulita, Francesk; Maroulis, Ioannis; Vailas, Michail; Triantafyllou, Tania; Theodorou, Dimitrios; Lostoridis, Eftychios; Nagorni, Eleni-Aikaterini; Tourountzi, Paraskevi; Baili, Efstratia; Charalabopoulos, Alexandros; Liakakos, Theodore; Schizas, Dimitrios; Kozadinos, Alexandros; Syllaios, Athanasios; Machairas, Nikolaos; Kykalos, Stylianos; Stamopoulos, Paraskevas; Delis, Spiros; Farazi-Chongouki, Christos; Kalaitzakis, Evangelos; Giannarakis, Miltiadis; Lasithiotakis, Konstantinos; Petra, Giorgia; Kalaitzakis, Evangelos; Gupta, Amit; Medappil, Noushif; Muthukrishnan, Vijayanand; Kamar, Jubin; Lal, Pawan; Agarwal, Rajendra; Magnoli, Matteo; Aonzo, Paolo; Serventi, Alberto; Di Lascio, Pierpaolo; Pinto, Margherita; Bergamini, Carlo; Bottari, Andrea; Fortuna, Laura; Martellucci, Jacopo; Cicako, Atea; Miglietta, Claudio; Morino, Mario; Delogu, Daniele; Picchetto, Andrea; Assenza, Marco; D’Ambrosio, Giancarlo; Argenio, Giulio; Armellino, Mariano Fortunato; Ioia, Giovanna; Occhionorelli, Savino; Andreotti, Dario; Domenico, Lacavalla; Luppi, Davide; Casadei, Massimiliano; Di Donato, Luca; Manoochehri, Farshad; Marchese, Tiziana Rita Lucia; Sergi, William; Manca, Roberto; Murgia, Raimondo; Piras, Enrico; Conti, Lorenzo; Gianazza, Simone; Rizzi, Andrea; Segalini, Edoardo; Monti, Marco; Iiritano, Elena; Mariani, Nicolò Maria; De Nicola, Enrico; Scifo, Giovanna; Pignata, Giusto; Andreuccetti, Jacopo; Fleres, Francesco; Clarizia, Guglielmo; Spolini, Alessandro; Biloslavo, Alan; Germani, Paola; Mastronardi, Manuela; Bogoni, Selene; Palmisano, Silvia; De Manzini, Nicolo’; Marino, Marco Vito; Martines, Gennaro; Trigiante, Giuseppe; Lagouvardou, Elpiniki; Anania, Gabriele; Bombardini, Cristina; Oppici, Dario; Pilia, Tiziana; Murzi, Valentina; Gessa, Emanuela; Bracale, Umberto; Di Nuzzo, Maria Michela; Peltrini, Roberto; Salvetti, Francesco; Viganò, Jacopo; Sganga, Gabriele; Bianchi, Valentina; Fransvea, Pietro; Fontana, Tommaso; Sarro, Giuliano; Dinuzzi, Vincenza Paola; Scaravilli, Luca; Papa, Mario Virgilio; Jovine, Elio; Ciabatti, Giulia; Mastrangelo, Laura; Rottoli, Matteo; Ricci, Claudio; Russo, Iris Shari; Aiolfi, Alberto; Bona, Davide; Lombardo, Francesca; Cianci, Pasquale; Sederino, Mariagrazia; Bini, Roberto; Chiara, Osvaldo; Cioffi, Stefano; Cantafio, Stefano; Coretti, Guido; Licitra, Edelweiss; Savino, Grazia; Grimaldi, Sergio; Porfidia, Raffaele; Moggia, Elisabetta; Garino, Mauro; Marafante, Chiara; Pesce, Antonio; Fabbri, Nicolò; Feo, Carlo Vittorio; Marra, Ester; Troian, Marina; Drigo, Davide; Nagliati, Carlo; Muratore, Andrea; Danna, Riccardo; Murgese, Alessandra; Crespi, Michele; Guerci, Claudio; Frontali, Alice; Ferrari, Luca; Guerci, Claudio; Favi, Francesco; Picariello, Erika; Rampini, Alessia; D’Acapito, Fabrizio; Ercolani, Giorgio; Solaini, Leonardo; Palmieri, Francesco; Calì, Matteo; Ferrara, Francesco; Muttillo, Irnerio Angelo; Muttillo, Edoardo Maria; Picardi, Biagio; Galleano, Raffaele; Badran, Ali; Ghazouani, Omar; Cervellera, Maurizio; Campanella, Gaetano; Papa, Gennaro; Di Bella, Annamaria; Perrone, Gennaro; Petracca, Gabriele Luciano; Prioriello, Concetta; Giuffrida, Mario; Cozzani, Federico; Rossini, Matteo; Inama, Marco; Butturini, Giovanni; Moretto, Gianluigi; Morelli, Luca; Candio, Giulio; Guadagni, Simone; Cicuttin, Enrico; Cremonini, Camilla; Tartaglia, Dario; Genovese, Valerio; Cillara, Nicola; Cannavera, Alessandro; Deserra, Antonello; Picciariello, Arcangelo; Papagni, Vincenzo; Vincenti, Leonardo; Bagaglini, Giulia; Sica, Giuseppe; Lapolla, Pierfrancesco; Brachini, Gioia; Bono, Dario; Nicotera, Antonella; Zago, Marcello; Sammartano, Fabrizio; Benuzzi, Laura; Stella, Marco; Rossi, Stefano; Cerioli, Alessandra; Puccioni, Caterina; Olmi, Stefano; Rubicondo, Carolina; Uccelli, Matteo; Guida, Anna; Lepiane, Pasquale; Sasia, Diego; Giraudo, Giorgio; Salomone, Sara; Belloni, Elena; Cossa, Alessandra; Lancellotti, Francesco; Caronna, Roberto; Chirletti, Piero; Saullo, Paolina; Troiano, Raffaele; Mucilli, Felice; Barone, Mirko; Ippoliti, Massimo; Grande, Michele; Sensi, Bruno; Siragusa, Leandro; Santini, Andrea; Di Carlo, Isidoro; Veroux, Massimiliano; Gioco, Rossella; Veroux, Gastone; Currò, Giuseppe; Ammendola, Michele; Komaei, Iman; Navarra, Giuseppe; Tonini, Valeria; Sartarelli, Lodovico; Ceresoli, Marco; Perrone, Stefano; Roccamatisi, Linda; Millo, Paolo; Brachet Contul, Riccardo; Ponte, Elisa; Zuin, Matteo; Portale, Giuseppe; Tonello, Alice Sabrina; Fratini, Geri; Bianchini, Matteo; Perotti, Bruno; Doria, Emanuele; Lunghi, Elia Giuseppe; Visconti, Diego; Al-Shami, Khayry; Awadi, Sajeda; Buwaitel, Mohammad Musallam Khalil; Naffa’, Mo’taz Fawzat Naief; Samhouri, Ahmad; Sawalha, Hatem; Ani, Mohd Firdaus Che; Fathil, Ida Nadiah Ahmed; Huei, Jih; Mohamad, Ikhwan Sani; Beristain-Hernandez, Jose-Luis; Garcia-Meza, Alejandro; Sepulveda-Rdriguez, Rafael; Hernández, Edgard Efren Lozada; Pinzón, Camilo Levi Acuña; Condoy, Jefferson Nieves; García, Francisco C. Becerra; Sadik, Mohammad; Kadir, Bushra; Devi, Jalpa; Seerani, Nandlal; Zainab, Null; Sohail-Asghar, Mohammad; Afzal, Ameer; Akbar, Ali; Lohse, Helmut Segovia; Lohse, Herald Segovia; Cabrera, Zamiara Solange Leon; Seto, Gaby Susana Yamamoto; Chiuyari, José Ríos; Ordemar, Jorge; Rodríguez, Martha; Orantia-Carlos, Abigail Cheska C.; Quitoy, Margie Antionette; Kwiatkowski, Andrzej; Mawlichanów, Maciej; Rocha, Mónica; Soares, Carlos; Stoian, Alexandru Rares; Draghici, Andreea Diana; Grigorean, Valentin Titus; Radulescu, Raluca Bievel; Zarnescu, Narcis Octavian; Costea, Radu Virgil; Zarnescu, Eugenia Claudia; Kurtenkov, Mikhail; Gendrikson, George; Alla-Angelina, Volovich; Arina, Tsurbanova; Kaldarov, Ayrat; Kaldarov, Ayrat; Gachabayov, Mahir; Abdullaev, Abakar; Milentijevic, Milica; Karamarkovic, Milovan; Panyko, Arpád; Radonak, Jozef; Soltes, Marek; Morán, Laura Álvarez; García, Haydée Calvo; Vega, Pilar Suárez; Estevez, Sergio; Ausania, Fabio; Farguell, Jordi; González-Abós, Carolina; Sánchez-Cabús, Santiago; Martín, Belén; Molina, Víctor; Oms, Luis; Ilzarbe, Lucas; Feijóo, Eva Pont; Perra, Elena Sofia; Rojas-Bonet, Noel; Penalba-Palmí, Rafael; Pérez-Bru, Susana; Tur-Martínez, Jaume; Álvarez-Torrado, Andrea; Domingo-Gonzalez, Marta; Tejedor-Tejada, Javier; del Alamo, Yaiza García; Mendoza-Moreno, Fernando; García-Moreno-Nisa, Francisca; Matías-García, Belén; Durán, Manuel; Calleja-Lozano, Rafael; de Villar, José Manuel Perez; Sánchez-Guillén, Luis; Caravaca, Iban; Triguero-Cánovas, Daniel; Aparicio, Antonio Carlos Maya; Meléndez, Blas Durán; Palacios, Andrea Masiá; Landaluce-Olavarria, Aitor; De Francisco, Mario; Estraviz-Mateos, Begoña; Alconchel, Felipe; Nicolás-López, Tatiana; Ramírez, Pablo; Muñoz-Cruzado, Virginia Duran; Ciuró, Felipe Parej; del Pozo, Eduardo Perea; Pizarro, Sergio Olivares; Cabrera, Vicente Herrera; Bayo, Jose Muros; Hamid, Hytham K. S.; Roesel, Raffaello; Cristaudi, Alessandra; Abbas, Kinan; Ali, Iyad; Tlili, Ahmed; Bayhan, Hüseyin; Türkoğlu, Mehmet Akif; Uzunoglu, Mustafa Yener; Azamat, Ibrahim Fethi; Omarov, Nail; Uymaz, Derya Salim; Altintoprak, Fatih; Akin, Emrah; First, Necattin; Das, Koray; Ozer, Nazmi; Seker, Ahmet; Kara, Yasin; Bozkurt, Mehmet Abdussamet; Kocataş, Ali; Atici, Semra Demirli; Akalin, Murat; Calik, Bulent; Colak, Elif; Altinel, Yuksel; Meric, Serhat; Aktimur, Yunus Emre; Hudson, Victoria; Duval, Jean-Luc; Khan, Mansoor; Saad, Ahmed; Kaur, Mandeep; Bradley, Alison; Fox, Katherine; Tomasi, Ivan; Beasley, Daniel; Prasanti, Alekhya Kotta; Kotecha, Pinky; Ebied, Husam; Paul, Michaela; Sheth, Hemant; Gerogiannis, Ioannis; Gaber, Mohannad; Sheikh, Zara; Seth, Shatadru; Kunitsyna, Maria; Leo, Cosimo Alex; Bellato, Vittoria; Zafar, Noman; Elserafy, Amr; Bond-smith, Giles; Tebala, Giovanni; Mathur, Pawan; Abid, Izza; Chidumije, Nnaemeka; Sandhar, Pardip; Ullah, Syed Osama Zohaib; Lezama, Tamara; Anwaar, Muhammad Hassan; Magee, Conor; Ahmed, Salma; Davies, Brooke; Apollos, Jeyakumar; Mccormack, Kieran; Choudhary, Hasham; Doulias, Triantafyllos; Morrison, Tamsin; Palepa, Anna; Cal, Fernando Bonilla; Sánchez, Lianet; Domínguez, Fabiana; Al-Raimi, Ibrahim; Alshargabi, Haneen; Meead, Abdullah; Chooklin, Serge; Chuklin, Serhii; Bilyak, Andriy; Null, Null. - In: UPDATES IN SURGERY. - ISSN 2038-131X. - 75:3(2023), pp. 493-522. [10.1007/s13304-023-01488-6]

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

Caronna, Roberto;
2023

Abstract

The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990).
2023
Acute pancreatitis; Infected pancreatic necrosis; International study; Mortality; Organ failure
01 Pubblicazione su rivista::01a Articolo in rivista
Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study / Podda, Mauro; Pellino, Gianluca; Di Saverio, Salomone; Coccolini, Federico; Pacella, Daniela; Cioffi, Stefano Piero Bernardo; Virdis, Francesco; Balla, Andrea; Ielpo, Benedetto; Pata, Francesco; Poillucci, Gaetano; Ortenzi, Monica; Damaskos, Dimitrios; De Simone, Belinda; Sartelli, Massimo; Leppaniemi, Ari; Jayant, Kumar; Catena, Fausto; Giuliani, Antonio; Di Martino, Marcello; Pisanu, Adolfo; Gerardi, Chiara; Gourgiotis, Stavros; Riboni, Cristiana; Giordano, Alessio; Ferrario, Luca; Agnoletti, Vanni; Kruger, Yoram; Mole, Damian; Agresta, Ferdinando; Prieto Calvo, Mikel; Wilson, Michael; Soggiu, Fiammetta; Hamdan, Alaa; Gomes, Carlos Augusto; Fraga, Gustavo; Ioannidis, Argyrios; Demetrashvili, Zaza; Sahani, Saaz; Bains, Lovenish; Khamees, Almu’Atasim; Ababneh, Hazim; Aljaiuossi, Osama; Pimentel, Samuel; Mohamad, Ikhwan Sani; Yusoff, Ahmad Ramzi; Zarnescu, Narcis Octavian; Calu, Valentin; Litvin, Andrey; Lesko, Dusan; Elmehrath, Ahmed; Elshami, Mohamedraed; de Santibañes, Martin; Gundara, Justin; Alawadhi, Kamel; Lui, Rashid; Julianov, Alexander; Ralon, Sergio; Garzali, Ibrahim-Umar; Machain, Gustavo M; Villalabeitia, Ibabe; Quispe-Cruz, Darwin Artidoro; Orantia, Abigail Cheska C.; Walędziak, Maciej; de Sá, Tiago Correia; Ali, Syed Muhammad; Kovacevic, Bojan; Noel, Colin; Abdalah, Haidar M.; Kchaou, Ali; Isik, Arda; Ansaloni, Luca; Biffl, Walter; Guerrieri, Mario; Sartori, Alberto; Abradelo, Manuel; Nigri, Giuseppe; Di Lorenzo, Nicola; Mingoli, Andrea; Chiarugi, Massimo; Di Menno Stavron, Juliana; Mazza, Oscar; Valenzuela, José Ignacio; Pachajoa, Diana Alejandra Pantoja; Alvarez, Fernando Andrés; Liaño, Julian Ezequiel; Tefay, Joan; Alshaikh, Abdulrahman; Hasan, Layla; Couto Gomes, Felipe; Calderan, Thiago R. A.; Hirano, Elcio S.; Dardanov, Dragomir; Julianov, Alexander; Saroglu, Azize; Atanasov, Boyko; Belev, Nikolay; Kovachev, Nikola; Chan, Shannon Melissa; Lok, Hon-Ting; Salcedo, Diego; Robayo, Diana; Triviño, María Alejandra; Manak, Jan; Sahani, Saaz; de Araujo, Jorann; Sethi, Ananya; Awad, Ahmed; Elbadawy, Merihan; Farid, Ahmed; Hanafy, Asmaa; Nafea, Ahmed; Sherief, Ghozy; Salah Alzhraa, Abbas; Abdelsalam, Wafaa; Emile, Sameh; Elfallal, Ahmed; Elfeki, Hossam; Elghadban, Hosam; Shoma, Ashraf; Shetiwy, Mohamed; Elbahnasawy, Mohamed; Mohamed, Salem; Hamed, Emad Fawzi; Khalil, Usama Ahmed; Chouillard, Elie; Gumbs, Andrew; Police, Andrea; Mabilia, Andrea; Khutsishvili, Kakhi; Tvaladze, Anano; Ioannidis, Orestis; Anestiadou, Elissavet; Loutzidou, Lydia; Konstantinidis, Konstantinis; Konstantinidou, Sofia; Manatakis, Dimitrios; Acheimastos, Vasileios; Tasis, Nikolaos; Michalopoulos, Nikolaos; Kokoropoulos, Panagiotis; Papadoliopoulou, Maria; Sotiropoulou, Maria; Kapiris, Stylianos; Metaxas, Panagiotis; Tsouknidas, Ioannis; Kefili, Despoina; Petrakis, George; Synekidou, Eirini; Dakis, Konstantinos; Alexandridou, Eirini; Papadopoulos, Aristeidis; Chouliaras, Christos; Mouzakis, Odysseas; Mulita, Francesk; Maroulis, Ioannis; Vailas, Michail; Triantafyllou, Tania; Theodorou, Dimitrios; Lostoridis, Eftychios; Nagorni, Eleni-Aikaterini; Tourountzi, Paraskevi; Baili, Efstratia; Charalabopoulos, Alexandros; Liakakos, Theodore; Schizas, Dimitrios; Kozadinos, Alexandros; Syllaios, Athanasios; Machairas, Nikolaos; Kykalos, Stylianos; Stamopoulos, Paraskevas; Delis, Spiros; Farazi-Chongouki, Christos; Kalaitzakis, Evangelos; Giannarakis, Miltiadis; Lasithiotakis, Konstantinos; Petra, Giorgia; Kalaitzakis, Evangelos; Gupta, Amit; Medappil, Noushif; Muthukrishnan, Vijayanand; Kamar, Jubin; Lal, Pawan; Agarwal, Rajendra; Magnoli, Matteo; Aonzo, Paolo; Serventi, Alberto; Di Lascio, Pierpaolo; Pinto, Margherita; Bergamini, Carlo; Bottari, Andrea; Fortuna, Laura; Martellucci, Jacopo; Cicako, Atea; Miglietta, Claudio; Morino, Mario; Delogu, Daniele; Picchetto, Andrea; Assenza, Marco; D’Ambrosio, Giancarlo; Argenio, Giulio; Armellino, Mariano Fortunato; Ioia, Giovanna; Occhionorelli, Savino; Andreotti, Dario; Domenico, Lacavalla; Luppi, Davide; Casadei, Massimiliano; Di Donato, Luca; Manoochehri, Farshad; Marchese, Tiziana Rita Lucia; Sergi, William; Manca, Roberto; Murgia, Raimondo; Piras, Enrico; Conti, Lorenzo; Gianazza, Simone; Rizzi, Andrea; Segalini, Edoardo; Monti, Marco; Iiritano, Elena; Mariani, Nicolò Maria; De Nicola, Enrico; Scifo, Giovanna; Pignata, Giusto; Andreuccetti, Jacopo; Fleres, Francesco; Clarizia, Guglielmo; Spolini, Alessandro; Biloslavo, Alan; Germani, Paola; Mastronardi, Manuela; Bogoni, Selene; Palmisano, Silvia; De Manzini, Nicolo’; Marino, Marco Vito; Martines, Gennaro; Trigiante, Giuseppe; Lagouvardou, Elpiniki; Anania, Gabriele; Bombardini, Cristina; Oppici, Dario; Pilia, Tiziana; Murzi, Valentina; Gessa, Emanuela; Bracale, Umberto; Di Nuzzo, Maria Michela; Peltrini, Roberto; Salvetti, Francesco; Viganò, Jacopo; Sganga, Gabriele; Bianchi, Valentina; Fransvea, Pietro; Fontana, Tommaso; Sarro, Giuliano; Dinuzzi, Vincenza Paola; Scaravilli, Luca; Papa, Mario Virgilio; Jovine, Elio; Ciabatti, Giulia; Mastrangelo, Laura; Rottoli, Matteo; Ricci, Claudio; Russo, Iris Shari; Aiolfi, Alberto; Bona, Davide; Lombardo, Francesca; Cianci, Pasquale; Sederino, Mariagrazia; Bini, Roberto; Chiara, Osvaldo; Cioffi, Stefano; Cantafio, Stefano; Coretti, Guido; Licitra, Edelweiss; Savino, Grazia; Grimaldi, Sergio; Porfidia, Raffaele; Moggia, Elisabetta; Garino, Mauro; Marafante, Chiara; Pesce, Antonio; Fabbri, Nicolò; Feo, Carlo Vittorio; Marra, Ester; Troian, Marina; Drigo, Davide; Nagliati, Carlo; Muratore, Andrea; Danna, Riccardo; Murgese, Alessandra; Crespi, Michele; Guerci, Claudio; Frontali, Alice; Ferrari, Luca; Guerci, Claudio; Favi, Francesco; Picariello, Erika; Rampini, Alessia; D’Acapito, Fabrizio; Ercolani, Giorgio; Solaini, Leonardo; Palmieri, Francesco; Calì, Matteo; 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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1705928
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