The present study investigates the utilization of nanoparticles based on poly-l-lactide (PLLA) and polyglycerol adipate (PGA), alone and blended, for the encapsulation of usnic acid (UA), a potent natural compound with various therapeutic properties including antimicrobial and anticancer activities. The development of these carriers offers an innovative approach to overcome the challenges associated with usnic acid's limited aqueous solubility, bioavailability, and hepatotoxicity. The nanosystems were characterized according to their physicochemical properties (among others, size, zeta potential, thermal properties), apparent aqueous solubility, and in vitro cytotoxicity. Interestingly, the nanocarrier obtained with the PLLA-PGA 50/50 weight ratio blend showed both the lowest size and the highest UA apparent solubility as well as the ability to decrease UA cytotoxicity towards human hepatocytes (HepG2 cells). This research opens new avenues for the effective utilization of these highly degradable and biocompatible PLLA-PGA blends as nanocarriers for reducing the cytotoxicity of usnic acid.

Nanostructured poly-l-lactide and polyglycerol adipate carriers for the encapsulation of usnic acid: a promising approach for hepatoprotection / Brugnoli, B; Perna, G; Alfano, S; Piozzi, A; Galantini, L; Axioti, E; Taresco, V; Mariano, A; Scotto d'Abusco, A; Vecchio Ciprioti, S; Francolini, I.. - In: POLYMERS. - ISSN 2073-4360. - 16:3(2024), pp. 1-18. [10.3390/polym16030427]

Nanostructured poly-l-lactide and polyglycerol adipate carriers for the encapsulation of usnic acid: a promising approach for hepatoprotection

Brugnoli B;Alfano S;Piozzi A;Galantini L;Mariano A;Scotto d'Abusco A;Vecchio Ciprioti S
;
Francolini I.
2024

Abstract

The present study investigates the utilization of nanoparticles based on poly-l-lactide (PLLA) and polyglycerol adipate (PGA), alone and blended, for the encapsulation of usnic acid (UA), a potent natural compound with various therapeutic properties including antimicrobial and anticancer activities. The development of these carriers offers an innovative approach to overcome the challenges associated with usnic acid's limited aqueous solubility, bioavailability, and hepatotoxicity. The nanosystems were characterized according to their physicochemical properties (among others, size, zeta potential, thermal properties), apparent aqueous solubility, and in vitro cytotoxicity. Interestingly, the nanocarrier obtained with the PLLA-PGA 50/50 weight ratio blend showed both the lowest size and the highest UA apparent solubility as well as the ability to decrease UA cytotoxicity towards human hepatocytes (HepG2 cells). This research opens new avenues for the effective utilization of these highly degradable and biocompatible PLLA-PGA blends as nanocarriers for reducing the cytotoxicity of usnic acid.
2024
drug delivery; drug hepatoprotection; poly-l-lactide; polyglycerol adipate; polymer nanoparticles; usnic acid.
01 Pubblicazione su rivista::01a Articolo in rivista
Nanostructured poly-l-lactide and polyglycerol adipate carriers for the encapsulation of usnic acid: a promising approach for hepatoprotection / Brugnoli, B; Perna, G; Alfano, S; Piozzi, A; Galantini, L; Axioti, E; Taresco, V; Mariano, A; Scotto d'Abusco, A; Vecchio Ciprioti, S; Francolini, I.. - In: POLYMERS. - ISSN 2073-4360. - 16:3(2024), pp. 1-18. [10.3390/polym16030427]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1705903
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