Introduction: Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity. Methods: This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis). Results: The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group ( P = 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20-1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA. Discussion: EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA.

A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study / Arpa, G., Vanoli, A., Antoci, F., Lenti Marco, V., Di Sabatino, A., Guerini, C., Grillo, F., Bianchi Paola, I., Aronico, N., Libera, L., Furlan, D., Travaglino, E., Nesi, G., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., Antonietta, D., et al.. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 119:3(2024), pp. 576-579. [10.14309/ajg.0000000000002585]

A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study

Vanoli Alessandro;Fiocca Roberto;D’Errico Antonietta;Rugge Massimo;Santini Donatella;Canzonieri Vincenzo;Caronna Roberto;Ciardi Antonio;
2024

Abstract

Introduction: Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity. Methods: This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis). Results: The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group ( P = 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20-1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA. Discussion: EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA.
2024
celiac disease; Crohn’s disease; immune-mediated disorders; mismatch repair; small bowel cancer
01 Pubblicazione su rivista::01a Articolo in rivista
A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study / Arpa, G., Vanoli, A., Antoci, F., Lenti Marco, V., Di Sabatino, A., Guerini, C., Grillo, F., Bianchi Paola, I., Aronico, N., Libera, L., Furlan, D., Travaglino, E., Nesi, G., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., Antonietta, D., et al.. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 119:3(2024), pp. 576-579. [10.14309/ajg.0000000000002585]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1705793
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 3
  • ???jsp.display-item.citation.isi??? ND
social impact