Introduction: Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity. Methods: This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis). Results: The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group ( P = 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20-1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA. Discussion: EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA.

A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study / Arpa, Giovanni; Vanoli, Alessandro; Antoci, Francesca; Lenti Marco, Vincenzo; Di Sabatino, Antonio; Guerini, Camilla; Grillo, Federica; Bianchi Paola, Ilaria; Aronico, Nicola; Libera, Laura; Furlan, Daniela; Travaglino, Erica; Nesi, Gabriella; Sampietro, Gianluca; Ardizzone, Sandro; Fociani, Paolo; Fiocca, Roberto; Latella, Giovanni; Sessa, Fausto; Antonietta, D’Errico; Malvi, Deborah; Mescoli, Claudia; Rugge, Massimo; Ferrero, Tefano; Poggioli, Gilberto; Rizzello, Fernando; Macciomei Maria, C; SANTINI MURATORI, Donatella; Volta, Mberto; De Giorgio, Roberto; Caio, Giacomo; Calabrò, Antonio; Ciacci, Carolina; D’Armiento, Aria; Rizzo, Aroldo; Solina, Gaspare; Tonelli, Francesco; Villanacci, Vincenzo; Cannizzaro, Enato; Canzonieri, Vincenzo; Florena Ada, M; Biancone, Livia; Monteleone, Giovanni; Caronna, Roberto; Ciardi, Antonio; Elli, Luca; Caprioli, Flavio; Vecchi, Maurizio; D’Incà, Renata; Zingone, Fabiana; D’Odorico, Anna; Oreggia, Barbara; Bonetti uca, Eggiani; Astegiano, Marco; Cantoro, Laura; Papi, Claudio; Sandri, Giancarlo; Silano, Marco; Usai, Paolo; Perfetti, Vittorio. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 119:3(2024), pp. 576-579. [10.14309/ajg.0000000000002585]

A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study

Vanoli Alessandro;Fiocca Roberto;D’Errico Antonietta;Rugge Massimo;Santini Donatella;Canzonieri Vincenzo;Caronna Roberto;Ciardi Antonio;
2024

Abstract

Introduction: Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity. Methods: This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis). Results: The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group ( P = 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20-1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA. Discussion: EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA.
2024
celiac disease; Crohn’s disease; immune-mediated disorders; mismatch repair; small bowel cancer
01 Pubblicazione su rivista::01a Articolo in rivista
A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study / Arpa, Giovanni; Vanoli, Alessandro; Antoci, Francesca; Lenti Marco, Vincenzo; Di Sabatino, Antonio; Guerini, Camilla; Grillo, Federica; Bianchi Paola, Ilaria; Aronico, Nicola; Libera, Laura; Furlan, Daniela; Travaglino, Erica; Nesi, Gabriella; Sampietro, Gianluca; Ardizzone, Sandro; Fociani, Paolo; Fiocca, Roberto; Latella, Giovanni; Sessa, Fausto; Antonietta, D’Errico; Malvi, Deborah; Mescoli, Claudia; Rugge, Massimo; Ferrero, Tefano; Poggioli, Gilberto; Rizzello, Fernando; Macciomei Maria, C; SANTINI MURATORI, Donatella; Volta, Mberto; De Giorgio, Roberto; Caio, Giacomo; Calabrò, Antonio; Ciacci, Carolina; D’Armiento, Aria; Rizzo, Aroldo; Solina, Gaspare; Tonelli, Francesco; Villanacci, Vincenzo; Cannizzaro, Enato; Canzonieri, Vincenzo; Florena Ada, M; Biancone, Livia; Monteleone, Giovanni; Caronna, Roberto; Ciardi, Antonio; Elli, Luca; Caprioli, Flavio; Vecchi, Maurizio; D’Incà, Renata; Zingone, Fabiana; D’Odorico, Anna; Oreggia, Barbara; Bonetti uca, Eggiani; Astegiano, Marco; Cantoro, Laura; Papi, Claudio; Sandri, Giancarlo; Silano, Marco; Usai, Paolo; Perfetti, Vittorio. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 119:3(2024), pp. 576-579. [10.14309/ajg.0000000000002585]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1705793
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact