Several studies evidenced that a sedentary lifestyle is related with higher levels of systemic inflammation and highlighted that physical activity can trigger anti-inflammatory effects. To evaluate the impact of self-prescribed physical activity on fitness status, metabolism, inflammation and immune-activation in people living with HIV, an interim analysis of the results of the clinical trial PRIMO (NCT03392805) was performed. Patients enrolled were divided in 2 groups on the basis of self-prescribed physical activity: a physically active group (self-prescribed physical activity) and a sedentary group. Physical fitness was evaluated by sport medicine specialists and related to nutritional status, anthropometric variables, adipokines levels (adiponectin, leptin, resistin), peripheral immune-activation (CD38, HLA-DR on CD4 and CD8), and plasma inflammatory markers (IL-6 and TNF-alpha). The physically active group had a better profile in anthropometric measures and aerobic fitness but did not show lower levels of immune-activation compared to sedentary group. Also serum IL-6, TNF-alpha, and adipokines levels showed no statistical differences. On the basis of these data, a regular self-organized physical activity seems useful to improve cardio-respiratory fitness, but unable to control HIV-related immune-activation.

Physical activity and HIV. Effects on fitness status, metabolism, inflammation and immune-activation / Ceccarelli, Giancarlo; Pinacchio, Claudia; Santinelli, Letizia; Adami, Paolo Emilio; Borrazzo, Cristian; Cavallari, Eugenio Nelson; Vullo, Annamaria; Innocenti, Giuseppe Pietro; Mezzaroma, Ivano; Mastroianni, Claudio Maria; D’Ettorre, Gabriella. - In: AIDS AND BEHAVIOR. - ISSN 1090-7165. - 24:4(2020), pp. 1042-1050. [10.1007/s10461-019-02510-y]

Physical activity and HIV. Effects on fitness status, metabolism, inflammation and immune-activation

Santinelli, Letizia;Adami, Paolo Emilio;Mezzaroma, Ivano;Mastroianni, Claudio Maria;d’Ettorre, Gabriella
2020

Abstract

Several studies evidenced that a sedentary lifestyle is related with higher levels of systemic inflammation and highlighted that physical activity can trigger anti-inflammatory effects. To evaluate the impact of self-prescribed physical activity on fitness status, metabolism, inflammation and immune-activation in people living with HIV, an interim analysis of the results of the clinical trial PRIMO (NCT03392805) was performed. Patients enrolled were divided in 2 groups on the basis of self-prescribed physical activity: a physically active group (self-prescribed physical activity) and a sedentary group. Physical fitness was evaluated by sport medicine specialists and related to nutritional status, anthropometric variables, adipokines levels (adiponectin, leptin, resistin), peripheral immune-activation (CD38, HLA-DR on CD4 and CD8), and plasma inflammatory markers (IL-6 and TNF-alpha). The physically active group had a better profile in anthropometric measures and aerobic fitness but did not show lower levels of immune-activation compared to sedentary group. Also serum IL-6, TNF-alpha, and adipokines levels showed no statistical differences. On the basis of these data, a regular self-organized physical activity seems useful to improve cardio-respiratory fitness, but unable to control HIV-related immune-activation.
2020
hiv; Immune-activation; life style; metabolism; physical activity; sport
01 Pubblicazione su rivista::01a Articolo in rivista
Physical activity and HIV. Effects on fitness status, metabolism, inflammation and immune-activation / Ceccarelli, Giancarlo; Pinacchio, Claudia; Santinelli, Letizia; Adami, Paolo Emilio; Borrazzo, Cristian; Cavallari, Eugenio Nelson; Vullo, Annamaria; Innocenti, Giuseppe Pietro; Mezzaroma, Ivano; Mastroianni, Claudio Maria; D’Ettorre, Gabriella. - In: AIDS AND BEHAVIOR. - ISSN 1090-7165. - 24:4(2020), pp. 1042-1050. [10.1007/s10461-019-02510-y]
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