In recent years, several studies described the close relationship between the composition of gut microbiota and brain functions, highlighting the importance of gut-derived metabolites in mediating neuronal and glial cells cross-talk in physiological and pathological condition. Gut dysbiosis may affects cerebral tumors growth and progression, but the specific metabolites involved in this modulation have not been identified yet. Using a syngeneic mouse model of glioma, we have investigated the role of dysbiosis induced by the administration of non-absorbable antibiotics on mouse metabolome and on tumor microenvironment. We report that antibiotics treatment induced: (1) alteration of the gut and brain metabolome profiles; (2) modeling of tumor microenvironment toward a pro-angiogenic phenotype in which microglia and glioma cells are actively involved; (3) increased glioma stemness; (4) trans-differentiation of glioma cells into endothelial precursor cells, thus increasing vasculogenesis. We propose glycine as a metabolite that, in ABX-induced dysbiosis, shapes brain microenvironment and contributes to glioma growth and progression.

Antibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice / Rosito, Maria; Maqbool, Javeria; Reccagni, Alice; Giampaoli, Ottavia; Sciubba, Fabio; Scavizzi, Ferdinando; Raspa, Marcello; Cordella, Federica; Tondo, Lucrezia; DI ANGELANTONIO, Silvia; Antonangeli, Fabrizio; Trettel, Flavia; Miccheli, Alfredo; D’Alessandro, Giuseppina; Limatola, Cristina. - In: CELL DEATH & DISEASE. - ISSN 2041-4889. - 210:15(2024). [10.1038/s41419-024-06578-w]

Antibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice

Maria Rosito
Conceptualization
;
Javeria Maqbool;Alice Reccagni;Ottavia Giampaoli;Fabio Sciubba;Marcello Raspa;Federica Cordella;Lucrezia Tondo;Silvia Di Angelantonio;Fabrizio Antonangeli;Flavia Trettel
;
Alfredo Miccheli;Giuseppina D’Alessandro;Cristina Limatola
Ultimo
Writing – Review & Editing
2024

Abstract

In recent years, several studies described the close relationship between the composition of gut microbiota and brain functions, highlighting the importance of gut-derived metabolites in mediating neuronal and glial cells cross-talk in physiological and pathological condition. Gut dysbiosis may affects cerebral tumors growth and progression, but the specific metabolites involved in this modulation have not been identified yet. Using a syngeneic mouse model of glioma, we have investigated the role of dysbiosis induced by the administration of non-absorbable antibiotics on mouse metabolome and on tumor microenvironment. We report that antibiotics treatment induced: (1) alteration of the gut and brain metabolome profiles; (2) modeling of tumor microenvironment toward a pro-angiogenic phenotype in which microglia and glioma cells are actively involved; (3) increased glioma stemness; (4) trans-differentiation of glioma cells into endothelial precursor cells, thus increasing vasculogenesis. We propose glycine as a metabolite that, in ABX-induced dysbiosis, shapes brain microenvironment and contributes to glioma growth and progression.
2024
glioma; antibiotics; vasculogenesis
01 Pubblicazione su rivista::01a Articolo in rivista
Antibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice / Rosito, Maria; Maqbool, Javeria; Reccagni, Alice; Giampaoli, Ottavia; Sciubba, Fabio; Scavizzi, Ferdinando; Raspa, Marcello; Cordella, Federica; Tondo, Lucrezia; DI ANGELANTONIO, Silvia; Antonangeli, Fabrizio; Trettel, Flavia; Miccheli, Alfredo; D’Alessandro, Giuseppina; Limatola, Cristina. - In: CELL DEATH & DISEASE. - ISSN 2041-4889. - 210:15(2024). [10.1038/s41419-024-06578-w]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1705020
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