Purpose: To evaluate the efficacy of Rituximab (RTX) therapy in patients affected by Vogt-Koyanagi-Harada (VKH) disease poorly controlled by traditional immunosuppressive treatment. Methods: Retrospective case series of recurrent VKH uveitis treated with intravenous RTX between January 2019 and November 2020. All patients were treated with intravenous RTX and underwent complete ophthalmic examination, best-corrected visual acuity (BCVA), fundus photography, subfoveal choroidal thickness (SFCT) measurement on enhanced depth imaging optical-coherence tomography (EDI-OCT), fluorescein, and indocyanine green angiography. Results: Five patients were included. All patients received at least 3 RTX infusions. Mean BCVA improved from 20/32 Snellen equivalent at baseline before RTX treatment to 20/28 Snellen equivalent (p = .008). Mean SFCT on EDI-OCT showed a reduction from 564.4 mu m(SD = 176.2) to 280.0 mu m(SD = 140.4) (p = .015). Follow-up ranged from 12 to 21 months, with a mean of 18.2 +/- 3.7 months. Conclusions: In these case series, RTX was effective in VHK disease poorly controlled by traditional immunosuppressive treatment.
Efficacy of rituximab treatment in Vogt-Koyanagi-Harada disease poorly controlled by traditional immunosuppressive treatment / Bolletta, E; Gozzi, F; Mastrofilippo, V; Pipitone, N; De Simone, L; Croci, S; Invernizzi, A; Adani, C; Iannetta, D; Coassin, M; Fontana, L; Salvarani, C; Cimino, L. - In: OCULAR IMMUNOLOGY AND INFLAMMATION. - ISSN 0927-3948. - 30:6(2022), pp. 1303-1308. [10.1080/09273948.2021.1880604]
Efficacy of rituximab treatment in Vogt-Koyanagi-Harada disease poorly controlled by traditional immunosuppressive treatment
Iannetta D;
2022
Abstract
Purpose: To evaluate the efficacy of Rituximab (RTX) therapy in patients affected by Vogt-Koyanagi-Harada (VKH) disease poorly controlled by traditional immunosuppressive treatment. Methods: Retrospective case series of recurrent VKH uveitis treated with intravenous RTX between January 2019 and November 2020. All patients were treated with intravenous RTX and underwent complete ophthalmic examination, best-corrected visual acuity (BCVA), fundus photography, subfoveal choroidal thickness (SFCT) measurement on enhanced depth imaging optical-coherence tomography (EDI-OCT), fluorescein, and indocyanine green angiography. Results: Five patients were included. All patients received at least 3 RTX infusions. Mean BCVA improved from 20/32 Snellen equivalent at baseline before RTX treatment to 20/28 Snellen equivalent (p = .008). Mean SFCT on EDI-OCT showed a reduction from 564.4 mu m(SD = 176.2) to 280.0 mu m(SD = 140.4) (p = .015). Follow-up ranged from 12 to 21 months, with a mean of 18.2 +/- 3.7 months. Conclusions: In these case series, RTX was effective in VHK disease poorly controlled by traditional immunosuppressive treatment.File | Dimensione | Formato | |
---|---|---|---|
Bolletta_Efficacy of Rituximab_2021.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
4.78 MB
Formato
Adobe PDF
|
4.78 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.