The European pediatric Soft tissue sarcoma Study Group analyzed all children with epithelioid hemangioendothelioma prospectively registered in the NRSTS-05 (EUDRACT 2005-001139-31) and in MTS-2008 (NCT00379457) studies: 10 patients with localized and one with metastatic disease. Median age was 14.3 years (range, 9.0-18.8). Local therapy was initial primary surgery in seven cases, and five patients received systemic therapy. No patients received radiotherapy. After a median follow-up of 50 months (range, 6-176) for living patients, nine patients remain alive off therapy and two died. Five-year progression free and overall survivals are, respectively, 77.1% (95% confidence interval [CI]: 34.5-93.9) and 74.1% (95% CI: 28.1-93.0).
Epithelioid hemangioendothelioma in children. The European Pediatric Soft Tissue Sarcoma Study Group experience / Orbach, Daniel; M Van Noesel, Max; Brennan, Bernadette; Corradini, Nadège; Alaggio, Rita; Ben Arush, Myriam; A Schoot, Reineke; Berlanga, Pablo; Zanetti, Ilaria; Lyngsie Hjalgrim, Lisa; Di Corti, Federica; Ramirez, Gema; Casanova, Michela; Ferrari, Andrea. - In: PEDIATRIC BLOOD & CANCER. - ISSN 1545-5017. - 69:10(2022). [10.1002/pbc.29882]
Epithelioid hemangioendothelioma in children. The European Pediatric Soft Tissue Sarcoma Study Group experience
Rita Alaggio;
2022
Abstract
The European pediatric Soft tissue sarcoma Study Group analyzed all children with epithelioid hemangioendothelioma prospectively registered in the NRSTS-05 (EUDRACT 2005-001139-31) and in MTS-2008 (NCT00379457) studies: 10 patients with localized and one with metastatic disease. Median age was 14.3 years (range, 9.0-18.8). Local therapy was initial primary surgery in seven cases, and five patients received systemic therapy. No patients received radiotherapy. After a median follow-up of 50 months (range, 6-176) for living patients, nine patients remain alive off therapy and two died. Five-year progression free and overall survivals are, respectively, 77.1% (95% confidence interval [CI]: 34.5-93.9) and 74.1% (95% CI: 28.1-93.0).| File | Dimensione | Formato | |
|---|---|---|---|
|
Orbach_Epithelioid_2022.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
268.61 kB
Formato
Adobe PDF
|
268.61 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
