The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.

The 5th edition of the World Health Organization classification of Haematolymphoid tumours. Myeloid and histiocytic/dendritic neoplasms / D Khoury, Joseph; Solary, Eric; Abla, Oussama; Akkari, Yassmine; Alaggio, Rita; F Apperley, Jane; Bejar, Rafael; Berti, Emilio; Busque, Lambert; C Chan, John K; Chen, Weina; Chen, Xueyan; Chng, Wee-Joo; K Choi, John; Colmenero, Isabel; E Coupland, Sarah; P Cross, Nicholas C; De Jong, Daphne; Tarek Elghetany, M; Takahashi, Emiko; Emile, Jean-Francois; Ferry, Judith; Fogelstrand, Linda; Fontenay, Michaela; Germing, Ulrich; Gujral, Sumeet; Haferlach, Torsten; Harrison, Claire; C Hodge, Jennelle; Hu, Shimin; H Jansen, Joop; Kanagal-Shamanna, Rashmi; M Kantarjian, Hagop; P Kratz, Christian; Li, Xiao-Qiu; S Lim, Megan; Loeb, Keith; Loghavi, Sanam; Marcogliese, Andrea; Meshinchi, Soheil; Michaels, Phillip; N Naresh, Kikkeri; Natkunam, Yasodha; Nejati, Reza; Ott, German; Padron, Eric; P Patel, Keyur; Patkar, Nikhil; Picarsic, Jennifer; Platzbecker, Uwe; Roberts, Irene; Schuh, Anna; Sewell, William; Siebert, Reiner; Tembhare, Prashant; Tyner, Jeffrey; Verstovsek, Srdan; Wang, Wei; Wood, Brent; Xiao, Wenbin; Yeung, Cecilia; Hochhaus, Andreas. - In: LEUKEMIA & LYMPHOMA REVIEWS. - ISSN 1060-6815. - 36:7(2022), pp. 1703-1719. [10.1038/s41375-022-01613-1]

The 5th edition of the World Health Organization classification of Haematolymphoid tumours. Myeloid and histiocytic/dendritic neoplasms

Rita Alaggio;
2022

Abstract

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.
2022
leukemia; classification; myelodisplasia
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The 5th edition of the World Health Organization classification of Haematolymphoid tumours. Myeloid and histiocytic/dendritic neoplasms / D Khoury, Joseph; Solary, Eric; Abla, Oussama; Akkari, Yassmine; Alaggio, Rita; F Apperley, Jane; Bejar, Rafael; Berti, Emilio; Busque, Lambert; C Chan, John K; Chen, Weina; Chen, Xueyan; Chng, Wee-Joo; K Choi, John; Colmenero, Isabel; E Coupland, Sarah; P Cross, Nicholas C; De Jong, Daphne; Tarek Elghetany, M; Takahashi, Emiko; Emile, Jean-Francois; Ferry, Judith; Fogelstrand, Linda; Fontenay, Michaela; Germing, Ulrich; Gujral, Sumeet; Haferlach, Torsten; Harrison, Claire; C Hodge, Jennelle; Hu, Shimin; H Jansen, Joop; Kanagal-Shamanna, Rashmi; M Kantarjian, Hagop; P Kratz, Christian; Li, Xiao-Qiu; S Lim, Megan; Loeb, Keith; Loghavi, Sanam; Marcogliese, Andrea; Meshinchi, Soheil; Michaels, Phillip; N Naresh, Kikkeri; Natkunam, Yasodha; Nejati, Reza; Ott, German; Padron, Eric; P Patel, Keyur; Patkar, Nikhil; Picarsic, Jennifer; Platzbecker, Uwe; Roberts, Irene; Schuh, Anna; Sewell, William; Siebert, Reiner; Tembhare, Prashant; Tyner, Jeffrey; Verstovsek, Srdan; Wang, Wei; Wood, Brent; Xiao, Wenbin; Yeung, Cecilia; Hochhaus, Andreas. - In: LEUKEMIA & LYMPHOMA REVIEWS. - ISSN 1060-6815. - 36:7(2022), pp. 1703-1719. [10.1038/s41375-022-01613-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1704317
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