: Nodal status is one of the most important prognostic factors for patients with apparent early stage endometrial cancer. The role of retroperitoneal staging in endometrial cancer is controversial. Nodal status provides useful prognostic data, and allows to tailor the need of postoperative treatments. However, two independent randomized trials showed that the execution of (pelvic) lymphadenectomy increases the risk of having surgery-related complication without improving patients' outcomes. Sentinel node mapping aims to achieve data regarding nodal status without increasing morbidity. Sentinel node mapping is the removal of first (clinically negative) lymph nodes draining the uterus. Several studies suggested that sentinel node mapping is not inferior to lymphadenectomy in identifying patients with nodal disease. More importantly, thorough ultrastaging sentinel node mapping allows the detection of low volume disease (micrometastases and isolated tumor cells), that are not always detectable via conventional pathological examination. Therefore, the adoption of sentinel node mapping guarantees a higher identification of patients with nodal disease than lymphadenectomy. Further evidence is needed to assess the value of various adjuvant strategies in patients with low volume disease and to tailor those treatments also on the basis of the molecular and genomic characterization of endometrial tumors.

Sentinel node mapping in endometrial cancer / Bogani, Giorgio; Giannini, Andrea; Vizza, Enrico; Di Donato, Violante; Raspagliesi, Francesco. - In: JOURNAL OF GYNECOLOGIC ONCOLOGY. - ISSN 2005-0380. - 35:1(2024). [10.3802/jgo.2024.35.e29]

Sentinel node mapping in endometrial cancer

Bogani, Giorgio;Giannini, Andrea;Di Donato, Violante;
2024

Abstract

: Nodal status is one of the most important prognostic factors for patients with apparent early stage endometrial cancer. The role of retroperitoneal staging in endometrial cancer is controversial. Nodal status provides useful prognostic data, and allows to tailor the need of postoperative treatments. However, two independent randomized trials showed that the execution of (pelvic) lymphadenectomy increases the risk of having surgery-related complication without improving patients' outcomes. Sentinel node mapping aims to achieve data regarding nodal status without increasing morbidity. Sentinel node mapping is the removal of first (clinically negative) lymph nodes draining the uterus. Several studies suggested that sentinel node mapping is not inferior to lymphadenectomy in identifying patients with nodal disease. More importantly, thorough ultrastaging sentinel node mapping allows the detection of low volume disease (micrometastases and isolated tumor cells), that are not always detectable via conventional pathological examination. Therefore, the adoption of sentinel node mapping guarantees a higher identification of patients with nodal disease than lymphadenectomy. Further evidence is needed to assess the value of various adjuvant strategies in patients with low volume disease and to tailor those treatments also on the basis of the molecular and genomic characterization of endometrial tumors.
2024
Lymph Nodes; Uterine Neoplasms
01 Pubblicazione su rivista::01a Articolo in rivista
Sentinel node mapping in endometrial cancer / Bogani, Giorgio; Giannini, Andrea; Vizza, Enrico; Di Donato, Violante; Raspagliesi, Francesco. - In: JOURNAL OF GYNECOLOGIC ONCOLOGY. - ISSN 2005-0380. - 35:1(2024). [10.3802/jgo.2024.35.e29]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1703683
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