Transcranial magnetic stimulation (TMS) is a non-invasive technique that is increasingly used to study the human brain. One of the principal outcome measures is the motor-evoked potential (MEP) elicited in a muscle following TMS over the primary motor cortex (M1), where it is used to estimate changes in corticospinal excitability. However, multiple elements play a role in MEP generation, so even apparently simple measures such as peak-to-peak amplitude have a complex interpretation. Here, we summarize what is currently known regarding the neural pathways and circuits that contribute to the MEP and discuss the factors that should be considered when interpreting MEP amplitude measured at rest in the context of motor processing and patients with neurological conditions. In the last part of this work, we also discuss how emerging technological approaches can be combined with TMS to improve our understanding of neural substrates that can influence MEPs. Overall, this review aims to highlight the capabilities and limitations of TMS that are important to recognize when attempting to disentangle sources that contribute to the physiological state-related changes in corticomotor excitability.

Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system / Spampinato, Danny Adrian; Ibanez, Jaime; Rocchi, Lorenzo; Rothwell, John. - In: THE JOURNAL OF PHYSIOLOGY. - ISSN 0022-3751. - 601:14(2023), pp. 2827-2851. [10.1113/JP281885]

Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system

Danny Adrian Spampinato
Primo
Conceptualization
;
2023

Abstract

Transcranial magnetic stimulation (TMS) is a non-invasive technique that is increasingly used to study the human brain. One of the principal outcome measures is the motor-evoked potential (MEP) elicited in a muscle following TMS over the primary motor cortex (M1), where it is used to estimate changes in corticospinal excitability. However, multiple elements play a role in MEP generation, so even apparently simple measures such as peak-to-peak amplitude have a complex interpretation. Here, we summarize what is currently known regarding the neural pathways and circuits that contribute to the MEP and discuss the factors that should be considered when interpreting MEP amplitude measured at rest in the context of motor processing and patients with neurological conditions. In the last part of this work, we also discuss how emerging technological approaches can be combined with TMS to improve our understanding of neural substrates that can influence MEPs. Overall, this review aims to highlight the capabilities and limitations of TMS that are important to recognize when attempting to disentangle sources that contribute to the physiological state-related changes in corticomotor excitability.
2023
motor cortex; motor-evoked potentials; movement; transcranial magnetic stimulation
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system / Spampinato, Danny Adrian; Ibanez, Jaime; Rocchi, Lorenzo; Rothwell, John. - In: THE JOURNAL OF PHYSIOLOGY. - ISSN 0022-3751. - 601:14(2023), pp. 2827-2851. [10.1113/JP281885]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1703290
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