Patients with the 22q11.2 deletion syndrome (DS) show an increased risk of developing a psychotic illness lifetime. 22q11.2DS may represent a reliable model for studying the neurobiological underpinnings of schizophrenia. The study of social inference abilities in a genetic condition at high risk for psychosis, like 22q11.2DS, may shed light on the relationships between neurocognitive processes and patients' daily general functioning. The study sample consisted of 1736 participants, divided into four groups: 22q11.2DS patients with diagnosis of psychotic disorder (DEL SCZ, N = 20); 22q11.2DS subjects with no diagnosis of psychosis (DEL, N = 43); patients diagnosed with schizophrenia without 22q11.2DS (SCZ, N = 893); and healthy controls (HC, N = 780). Social cognition was assessed through The Awareness of Social Inference Test (TASIT) and general functioning through the Specific Levels of Functioning (SLoF) scale. We analysed data through regression analysis. The SCZ and DEL groups had similar levels of global functioning; they both had significantly lower SLoF Total scores than HC (p < .001); the DEL SCZ group showed significantly lower scores compared to the other groups (SCZ, p = .004; DEL, p = .003; HC, p < .001). A significant deficit in social cognition was observed in the three clinical groups. In the DEL SCZ and SCZ groups, TASIT scores significantly predicted global functioning (p < .05). Our findings of social cognition deficit in psychosis-prone patients point to the possible future adoption of rehabilitation programmes, like Social Skills Training and Cognitive Remediation, during premorbid stages of psychosis.

Social cognition and real‐life functioning in patient samples with 22q11.2 deletion syndrome with or without psychosis, compared to a large sample of patients with schizophrenia only and healthy controls / Frascarelli, Marianna; Accinni, Tommaso; Buzzanca, Antonino; Carlone, Luca; Ghezzi, Francesco; Moschillo, Antonella; Kotzalidis, Georgios D.; Bucci, Paola; Giordano, GIULIA MARIA; Fanella, Martina; DI BONAVENTURA, Carlo; Putotto, Carolina; MARINO TAUSSIG DE BODONIA, Bruno; Pasquini, Massimo; Biondi, Massimo; DI FABIO, Fabio. - In: JOURNAL OF NEUROPSYCHOLOGY. - ISSN 1748-6653. - 17:3(2023), pp. 564-583. [10.1111/jnp.12322]

Social cognition and real‐life functioning in patient samples with 22q11.2 deletion syndrome with or without psychosis, compared to a large sample of patients with schizophrenia only and healthy controls

Marianna Frascarelli;Tommaso Accinni;Antonino Buzzanca;Luca Carlone;Francesco Ghezzi;Antonella Moschillo;Paola Bucci;Giulia Maria Giordano;Martina Fanella;Carlo Di Bonaventura;Carolina Putotto;Bruno Marino Taussig De Bodonia;Massimo Pasquini;Massimo Biondi;Fabio Di Fabio
2023

Abstract

Patients with the 22q11.2 deletion syndrome (DS) show an increased risk of developing a psychotic illness lifetime. 22q11.2DS may represent a reliable model for studying the neurobiological underpinnings of schizophrenia. The study of social inference abilities in a genetic condition at high risk for psychosis, like 22q11.2DS, may shed light on the relationships between neurocognitive processes and patients' daily general functioning. The study sample consisted of 1736 participants, divided into four groups: 22q11.2DS patients with diagnosis of psychotic disorder (DEL SCZ, N = 20); 22q11.2DS subjects with no diagnosis of psychosis (DEL, N = 43); patients diagnosed with schizophrenia without 22q11.2DS (SCZ, N = 893); and healthy controls (HC, N = 780). Social cognition was assessed through The Awareness of Social Inference Test (TASIT) and general functioning through the Specific Levels of Functioning (SLoF) scale. We analysed data through regression analysis. The SCZ and DEL groups had similar levels of global functioning; they both had significantly lower SLoF Total scores than HC (p < .001); the DEL SCZ group showed significantly lower scores compared to the other groups (SCZ, p = .004; DEL, p = .003; HC, p < .001). A significant deficit in social cognition was observed in the three clinical groups. In the DEL SCZ and SCZ groups, TASIT scores significantly predicted global functioning (p < .05). Our findings of social cognition deficit in psychosis-prone patients point to the possible future adoption of rehabilitation programmes, like Social Skills Training and Cognitive Remediation, during premorbid stages of psychosis.
2023
22q11 deletion syndrome; functional outcome; psychosis; schizophrenia; social cognition
01 Pubblicazione su rivista::01a Articolo in rivista
Social cognition and real‐life functioning in patient samples with 22q11.2 deletion syndrome with or without psychosis, compared to a large sample of patients with schizophrenia only and healthy controls / Frascarelli, Marianna; Accinni, Tommaso; Buzzanca, Antonino; Carlone, Luca; Ghezzi, Francesco; Moschillo, Antonella; Kotzalidis, Georgios D.; Bucci, Paola; Giordano, GIULIA MARIA; Fanella, Martina; DI BONAVENTURA, Carlo; Putotto, Carolina; MARINO TAUSSIG DE BODONIA, Bruno; Pasquini, Massimo; Biondi, Massimo; DI FABIO, Fabio. - In: JOURNAL OF NEUROPSYCHOLOGY. - ISSN 1748-6653. - 17:3(2023), pp. 564-583. [10.1111/jnp.12322]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1702621
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