Aim: The study was designed to generate real-world evidence on IDegLira in the Italian clinical practice in two groups of patients with type 2 diabetes (T2D), switching to IDegLira either from a basal only (basal group) or basal-bolus insulin regimen (BB group). Materials and methods: This was a non-interventional, multicentre, single-cohort, prospective study assessing the long-term glycaemic control in patients with T2D, who switched to IDegLira from a basal insulin ± glucose-lowering medication regimen with or without a bolus insulin component for approximately 18 months, conducted in 28 Italian diabetes centres. The primary endpoint was the change in glycated haemoglobin (HbA1c) levels from baseline to 6 months after IDegLira initiation. Results: The study included 358 patients with a mean age 67.2 years and diabetes duration of 15.7 years. HbA1c significantly decreased from IDegLira start to all study time points in the overall population (basal group -1.19%; BB group -0.60% at the end of observation). Patients achieving HbA1c <7% levels increased from 12.9% (n = 43) to 40.3% (n = 110) at 18 months. Fasting blood glucose and body weight also significantly decreased in both groups, although more in the BB group. Overall, 14.3% of completed patients had an intensification of treatment (mainly in the basal group) and 48.6% had a simplification of treatment (mainly in the BB group). Conclusions: Switching to IDegLira in a real-world clinical setting is a valid therapeutic option for patients with T2D with inadequate glycaemic control on basal or BB insulin regimen and/or need to simplify their insulin therapy, with specific reasons and therapeutic goals according to different T2D management trajectories.

IDegLira for the real-world treatment of type 2 diabetes in Italy. Final results from the REX observational study / Paolo Fadini, Gian; Buzzetti, Raffaella; Pitocco, Dario; Tortato, Elena; Scatena, Alessia; Lamacchia, Olga; Lastoria, Giusi; Simoni, Lucia; Consoli, Agostino; study group, Rex. - In: DIABETES, OBESITY AND METABOLISM. - ISSN 1462-8902. - (2024).

IDegLira for the real-world treatment of type 2 diabetes in Italy. Final results from the REX observational study

Raffaella Buzzetti;
2024

Abstract

Aim: The study was designed to generate real-world evidence on IDegLira in the Italian clinical practice in two groups of patients with type 2 diabetes (T2D), switching to IDegLira either from a basal only (basal group) or basal-bolus insulin regimen (BB group). Materials and methods: This was a non-interventional, multicentre, single-cohort, prospective study assessing the long-term glycaemic control in patients with T2D, who switched to IDegLira from a basal insulin ± glucose-lowering medication regimen with or without a bolus insulin component for approximately 18 months, conducted in 28 Italian diabetes centres. The primary endpoint was the change in glycated haemoglobin (HbA1c) levels from baseline to 6 months after IDegLira initiation. Results: The study included 358 patients with a mean age 67.2 years and diabetes duration of 15.7 years. HbA1c significantly decreased from IDegLira start to all study time points in the overall population (basal group -1.19%; BB group -0.60% at the end of observation). Patients achieving HbA1c <7% levels increased from 12.9% (n = 43) to 40.3% (n = 110) at 18 months. Fasting blood glucose and body weight also significantly decreased in both groups, although more in the BB group. Overall, 14.3% of completed patients had an intensification of treatment (mainly in the basal group) and 48.6% had a simplification of treatment (mainly in the BB group). Conclusions: Switching to IDegLira in a real-world clinical setting is a valid therapeutic option for patients with T2D with inadequate glycaemic control on basal or BB insulin regimen and/or need to simplify their insulin therapy, with specific reasons and therapeutic goals according to different T2D management trajectories.
2024
basal insulin; glycaemic control; real-world evidence; type 2 diabetes
01 Pubblicazione su rivista::01a Articolo in rivista
IDegLira for the real-world treatment of type 2 diabetes in Italy. Final results from the REX observational study / Paolo Fadini, Gian; Buzzetti, Raffaella; Pitocco, Dario; Tortato, Elena; Scatena, Alessia; Lamacchia, Olga; Lastoria, Giusi; Simoni, Lucia; Consoli, Agostino; study group, Rex. - In: DIABETES, OBESITY AND METABOLISM. - ISSN 1462-8902. - (2024).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1702374
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