A novel C3‐symmetric multi‐amino catalyst was synthesized and evaluated in the asymmetric Michael addition to produce warfarin and its analogues. The multi‐amino catalyst turned out to be efficient up to 1% molar without the use of acidic additives providing the desired product in 82% yield and maintaining good level of enantioselectivity. ESI‐MS experiments together with data supplied by theoretical models allowed us the understand the operating mechanism of the catalyst, clarifying the role of the amine functions and confirming the catalyst’s multifunctionality. The presence of three active catalytic sites makes it easy its anchoring to silica as solid support for applications in heterogeneous phase catalysis.

A C3‐Symmetric Amino Organocatalyst for Asymmetric Synthesis of Warfarin and Analogues: Mechanistic Insight from ESI‐MS Spectrometry and Computational Calculations / Sorato, Andrea; DE ANGELIS, Martina; Oljira, SHILASHI BADASA; Pierini, Marco; Mazzoccanti, Giulia; Donzello, Maria Pia; Ciogli, Alessia. - In: CHEMCATCHEM. - ISSN 1867-3880. - 16:11(2024), pp. 1-8. [10.1002/cctc.202400031]

A C3‐Symmetric Amino Organocatalyst for Asymmetric Synthesis of Warfarin and Analogues: Mechanistic Insight from ESI‐MS Spectrometry and Computational Calculations

Andrea Sorato;Martina De Angelis;Shilashi Badasa Oljira;Marco Pierini;Giulia Mazzoccanti;Maria Pia Donzello;Alessia CIOGLI
2024

Abstract

A novel C3‐symmetric multi‐amino catalyst was synthesized and evaluated in the asymmetric Michael addition to produce warfarin and its analogues. The multi‐amino catalyst turned out to be efficient up to 1% molar without the use of acidic additives providing the desired product in 82% yield and maintaining good level of enantioselectivity. ESI‐MS experiments together with data supplied by theoretical models allowed us the understand the operating mechanism of the catalyst, clarifying the role of the amine functions and confirming the catalyst’s multifunctionality. The presence of three active catalytic sites makes it easy its anchoring to silica as solid support for applications in heterogeneous phase catalysis.
2024
C3-symmetric; asymmetric synthesis; ESI-MS spectrometry
01 Pubblicazione su rivista::01a Articolo in rivista
A C3‐Symmetric Amino Organocatalyst for Asymmetric Synthesis of Warfarin and Analogues: Mechanistic Insight from ESI‐MS Spectrometry and Computational Calculations / Sorato, Andrea; DE ANGELIS, Martina; Oljira, SHILASHI BADASA; Pierini, Marco; Mazzoccanti, Giulia; Donzello, Maria Pia; Ciogli, Alessia. - In: CHEMCATCHEM. - ISSN 1867-3880. - 16:11(2024), pp. 1-8. [10.1002/cctc.202400031]
File allegati a questo prodotto
File Dimensione Formato  
Sorato_A-C3-Symmetric_2024.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 3.08 MB
Formato Adobe PDF
3.08 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1702295
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact