Astrocytes are highly plastic cells whose activity is essential to maintain the cerebral homeostasis, regulating synaptogenesis and synaptic transmission, vascular and metabolic functions, ions, neuro- and gliotransmitters concentrations. In pathological conditions, astrocytes may undergo transient or long-lasting molecular and functional changes that contribute to disease resolutionor exacerbation. In recent years, many studies demonstrated that non-neoplastic astrocytes are key cells of the tumor microenvironment that contribute to the pathogenesis of glioblastoma, the most common primary malignant brain tumor and of secondary metastatic brain tumors.This Mini Review covers the recent development of research on non-neoplastic astrocytes as tumor-modulators. Their double-edged capability to promote cancer progression or to represent potential tools to counteract brain tumors will be discussed.

Non-neoplastic astrocytes: key players for brain tumor progression / Catalano, M; Limatola, C; Trettel, F.. - In: FRONTIERS IN CELLULAR NEUROSCIENCE. - ISSN 1662-5102. - 17:(2024). [10.3389/fncel.2023.1352130]

Non-neoplastic astrocytes: key players for brain tumor progression.

Catalano M
Writing – Review & Editing
;
Limatola C
Writing – Review & Editing
;
Trettel F.
Writing – Review & Editing
2024

Abstract

Astrocytes are highly plastic cells whose activity is essential to maintain the cerebral homeostasis, regulating synaptogenesis and synaptic transmission, vascular and metabolic functions, ions, neuro- and gliotransmitters concentrations. In pathological conditions, astrocytes may undergo transient or long-lasting molecular and functional changes that contribute to disease resolutionor exacerbation. In recent years, many studies demonstrated that non-neoplastic astrocytes are key cells of the tumor microenvironment that contribute to the pathogenesis of glioblastoma, the most common primary malignant brain tumor and of secondary metastatic brain tumors.This Mini Review covers the recent development of research on non-neoplastic astrocytes as tumor-modulators. Their double-edged capability to promote cancer progression or to represent potential tools to counteract brain tumors will be discussed.
2024
non-neoplastic astrocytes, primary brain tumors, metastatic brain tumors, glioma, tumor microenvironment
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Non-neoplastic astrocytes: key players for brain tumor progression / Catalano, M; Limatola, C; Trettel, F.. - In: FRONTIERS IN CELLULAR NEUROSCIENCE. - ISSN 1662-5102. - 17:(2024). [10.3389/fncel.2023.1352130]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1701566
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