Background: We estimated the prevalence and clinical outcomes of sarcopenia among breast cancer patients. (2) Methods: A systematic literature search was carried out for the period between July 2023 and October 2023. Studies with breast cancer patients evaluated for sarcopenia in relation to overall survival (OS), progression-free survival (PFS), relapse of disease (DFS), pathological complete response (pCR), or toxicity to chemotherapy were included. (3) Results: Out of 359 screened studies, 16 were eligible for meta-analysis, including 6130 patients, of whom 5284 with non-MBC. Sarcopenia was evaluated with the computed tomography (CT) scan skeletal muscle index and, in two studies, with the dual-energy x-ray absorptiometry (DEXA) appendicular lean mass index. Using different classifications and cut-off points, overall, there were 2007 sarcopenic patients (33%), of whom 1901 (95%) presented with non-MBC. Sarcopenia was associated with a 33% and 29% higher risk of mortality and progression/relapse of disease, respectively. Sarcopenic patients were more likely to develop grade 3–4 toxicity (OR 3.58, 95% CI 2.11–6.06, p < 0.0001). In the neoadjuvant setting, a higher rate of pCR was observed among sarcopenic patients (49%) (OR 2.74, 95% CI 0.92–8.22). (4) Conclusions: Our meta-analysis confirms the correlation between sarcopenia and negative outcomes, especially in terms of higher toxicity.

Sarcopenia in Breast Cancer Patients: A Systematic Review and Meta-Analysis / Roberto, Michela; Barchiesi, Giacomo; Resuli, Blerina; Verrico, Monica; Speranza, Iolanda; Cristofani, Leonardo; Pediconi, Federica; Tomao, Federica; Botticelli, Andrea; Santini, Daniele. - In: CANCERS. - ISSN 2072-6694. - 16:3(2024). [10.3390/cancers16030596]

Sarcopenia in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Roberto, Michela
;
Barchiesi, Giacomo;Resuli, Blerina;Verrico, Monica;Cristofani, Leonardo;Pediconi, Federica;Tomao, Federica;Botticelli, Andrea;Santini, Daniele
2024

Abstract

Background: We estimated the prevalence and clinical outcomes of sarcopenia among breast cancer patients. (2) Methods: A systematic literature search was carried out for the period between July 2023 and October 2023. Studies with breast cancer patients evaluated for sarcopenia in relation to overall survival (OS), progression-free survival (PFS), relapse of disease (DFS), pathological complete response (pCR), or toxicity to chemotherapy were included. (3) Results: Out of 359 screened studies, 16 were eligible for meta-analysis, including 6130 patients, of whom 5284 with non-MBC. Sarcopenia was evaluated with the computed tomography (CT) scan skeletal muscle index and, in two studies, with the dual-energy x-ray absorptiometry (DEXA) appendicular lean mass index. Using different classifications and cut-off points, overall, there were 2007 sarcopenic patients (33%), of whom 1901 (95%) presented with non-MBC. Sarcopenia was associated with a 33% and 29% higher risk of mortality and progression/relapse of disease, respectively. Sarcopenic patients were more likely to develop grade 3–4 toxicity (OR 3.58, 95% CI 2.11–6.06, p < 0.0001). In the neoadjuvant setting, a higher rate of pCR was observed among sarcopenic patients (49%) (OR 2.74, 95% CI 0.92–8.22). (4) Conclusions: Our meta-analysis confirms the correlation between sarcopenia and negative outcomes, especially in terms of higher toxicity.
2024
sarcopenia; breast cancer; lean muscle mass; skeletal muscle index (SMI); prognostic factor; body composition
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Sarcopenia in Breast Cancer Patients: A Systematic Review and Meta-Analysis / Roberto, Michela; Barchiesi, Giacomo; Resuli, Blerina; Verrico, Monica; Speranza, Iolanda; Cristofani, Leonardo; Pediconi, Federica; Tomao, Federica; Botticelli, Andrea; Santini, Daniele. - In: CANCERS. - ISSN 2072-6694. - 16:3(2024). [10.3390/cancers16030596]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1701336
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