We investigate band broadening in the most widely adopted configuration of micro-pillar array columns ((Formula presented.) PACs)—specifically, a cylindrical pillar array where both the pillar walls and the channel bottom are coated with a thin layer of mesoporous material. The two-zone moment analysis method is adopted to investigate the dispersion properties of (Formula presented.) PACs in a broad range of shell thicknesses, reduced fluid velocities, and retention factors. Three different models of the unit cell, of increasing complexity, have been implemented, namely a two-dimensional model and two different three-dimensional models with and without the retentive bottom layer, the presence of which seems to have a very significant effect on the plate height curves. Model predictions are compared with experimental van Deemter curves for uncoated and coated porous layers, and a robust relationship between the intra-particle (porous-zone) diffusion coefficient (Formula presented.) and the retention factor (Formula presented.) is established.
Prediction of Plate Height Curves of Porous-Shell Pillar Array Columns Micro-Pillar Array Columns / Venditti, C.; Desmet, G.; Adrover, A.. - In: SEPARATIONS. - ISSN 2297-8739. - 11:1(2024). [10.3390/separations11010022]
Prediction of Plate Height Curves of Porous-Shell Pillar Array Columns Micro-Pillar Array Columns
Venditti C.;Adrover A.
2024
Abstract
We investigate band broadening in the most widely adopted configuration of micro-pillar array columns ((Formula presented.) PACs)—specifically, a cylindrical pillar array where both the pillar walls and the channel bottom are coated with a thin layer of mesoporous material. The two-zone moment analysis method is adopted to investigate the dispersion properties of (Formula presented.) PACs in a broad range of shell thicknesses, reduced fluid velocities, and retention factors. Three different models of the unit cell, of increasing complexity, have been implemented, namely a two-dimensional model and two different three-dimensional models with and without the retentive bottom layer, the presence of which seems to have a very significant effect on the plate height curves. Model predictions are compared with experimental van Deemter curves for uncoated and coated porous layers, and a robust relationship between the intra-particle (porous-zone) diffusion coefficient (Formula presented.) and the retention factor (Formula presented.) is established.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.