Purpose: The GOSAFE study evaluates risk factors for failing to achieve good quality of life (QoL) and functional recovery (FR) in older patients undergoing surgery for colon and rectal cancer. Methods: Patients age 70 years and older undergoing major elective colorectal surgery were prospectively enrolled. Frailty assessment was performed and outcomes, including QoL (EQ-5D-3L) recorded (3/6 months postoperatively). Postoperative FR was defined as a combination of Activity of Daily Living ≥5 + Timed Up & Go test <20 seconds + MiniCog >2. Results: Prospective complete data were available for 625/646 consecutive patients (96.9%; 435 colon and 190 rectal cancer), 52.6% men, and median age was 79.0 years (IQR, 74.6-82.9 years). Surgery was minimally invasive in 73% of patients (321/435 colon; 135/190 rectum). At 3-6 months, 68.9%-70.3% patients experienced equal/better QoL (72.8%-72.9% colon, 60.1%-63.9% rectal cancer). At logistic regression analysis, preoperative Flemish Triage Risk Screening Tool ≥2 (3-month odds ratio [OR], 1.68; 95% CI, 1.04 to 2.73; P = .034, 6-month OR, 1.71; 95% CI, 1.06 to 2.75; P = .027) and postoperative complications (3-month OR, 2.03; 95% CI, 1.20 to 3.42; P = .008, 6-month OR, 2.56; 95% CI, 1.15 to 5.68; P = .02) are associated with decreased QoL after colectomy. Eastern Collaborative Oncology Group performance status (ECOG PS) ≥2 is a strong predictor of postoperative QoL decline in the rectal cancer subgroup (OR, 3.81; 95% CI, 1.45 to 9.92; P = .006). FR was reported by 254/323 (78.6%) patients with colon and 94/133 (70.6%) with rectal cancer. Charlson Age Comorbidity Index ≥7 (OR, 2.59; 95% CI, 1.26 to 5.32; P = .009), ECOG ≥2 (OR, 3.12; 95% CI, 1.36 to 7.20; P = .007 colon; OR, 4.61; 95% CI, 1.45 to 14.63; P = .009 rectal surgery), severe complications (OR, 17.33; 95% CI, 7.30 to 40.8; P < .001), fTRST ≥2 (OR, 2.71; 95% CI, 1.40 to 5.25; P = .003), and palliative surgery (OR, 4.11; 95% CI, 1.29 to 13.07; P = .017) are risk factors for not achieving FR. Conclusion: The majority of older patients experience good QoL and stay independent after colorectal cancer surgery. Predictors for failing to achieve these essential outcomes are now defined to guide patients' and families' preoperative counseling.
Predicting Functional Recovery and Quality of Life in Older Patients Undergoing Colorectal Cancer Surgery. Real-World Data From the International GOSAFE Study / Montroni, Isacco; Ugolini, Giampaolo; M Saur, Nicole; Rostoft, Siri; Spinelli, Antonino; L Van Leeuwen, Barbara; De Liguori Carino, Nicola; Ghignone, Federico; T Jaklitsch, Michael; Kenig, Jakub; Garutti, Anna; Zingaretti, Chiara; Foca, Flavia; Vertogen, Bernadette; Nanni, Oriana; D Wexner, Steven; A Audisio, Riccardo; Taffurelli, Giovanni; Zattoni, Davide; Tramelli, Paola; Sermonesi, Giacomo; Ercolani, Giorgio; Tauceri, Francesca; Perenze, Barbara; Di Pietrantonio, Daniela; Mirarchi, Mariateresa; Garulli, Gianluca; Alagna, Vincenzo; Lucchi, Andrea; Pirrera, Basilio; Monari, Francesco; Conti, Luigi; Capelli, Patrizio; Romboli, Andrea; Palmieri, Gerardo; Banchini, Filippo; Di Candido, Francesca; Carvello, Michele; Sacchi, Matteo; DE LUCIA, Francesca; Foppa, Caterina; Marano, Luigi; Spaziani, Alessandro; Castagnoli, Giampaolo; Bartoli, Alberto; Frain, Laura; W Fox, Sam; Cardin, Kristin; E De Leon, Luis; Trompetto, Mario; Gallo, Gaetano; Realis Luc, Alberto; Clerico, Giuseppe; Sammarco, Giuseppe; De Luca, Raffaele; Simone, Michele; Albano, Anna; Fejka, Michael; Is Bleier, Joshua; Plas, Matthijs; van der Wal-Huisman, Hanneke; Costanzi, Andrea; Mari, Giulio; Maggioni, Dario; Pellegrino, Roberta; Riggio, Valentina; Kenig, Jakub; Szabat, Kinga; Scabini, Stefano; Pertile, Davide; Epis, Lorenzo; Massobrio, Andrea; Soriero, Domenico; Nesbakken, Arild; Flåten Backe, Ingeborg; Lønn, Mariann; Ferrari, Giovanni; Mazzola, Michele; Magistro, Carmelo; Achilli, Pietro; Giani, Alessandro; Ioannidis, Orestis; Loutzidou, Lydia; Galanos-Demiris, Konstantinos; Pellino, Gianluca; Balducci, Genoveffa; Frezza, Barbara; Lucarini, Alessio; Santos, Claudia; Cooper, Lisa; Siam, Baha; Levy, Yochai; Brenner, Baruch; Kashtan, Hanoch; Belgrano, Valerio; Decian, Franco; Palermo, Beatrice; Eggenhöffner, Roberto; Albertelli, Manuela; Sánchez-Guillén, Luis; Arroyo, Antonio; López-Rodríguez, Francisco; Lario, Sandra; Lillo, Cristina; Baltatzis, Minas; C Chan, Anthony K; K Siriwardena, Ajith; Da Silva, Giovanna. - In: JOURNAL OF CLINICAL ONCOLOGY. - ISSN 1527-7755. - 41:34(2023), pp. 1-23. [10.1200/JCO.22.02195]
Predicting Functional Recovery and Quality of Life in Older Patients Undergoing Colorectal Cancer Surgery. Real-World Data From the International GOSAFE Study
Andrea Lucchi;Francesca De Lucia;Alessandro Spaziani;Alberto Bartoli;Gaetano Gallo;Giuseppe Sammarco;Roberta Pellegrino;Giovanni Ferrari;Michele Mazzola;Genoveffa Balducci;Barbara Frezza;Alessio LucariniMembro del Collaboration Group
;Cristina Lillo;
2023
Abstract
Purpose: The GOSAFE study evaluates risk factors for failing to achieve good quality of life (QoL) and functional recovery (FR) in older patients undergoing surgery for colon and rectal cancer. Methods: Patients age 70 years and older undergoing major elective colorectal surgery were prospectively enrolled. Frailty assessment was performed and outcomes, including QoL (EQ-5D-3L) recorded (3/6 months postoperatively). Postoperative FR was defined as a combination of Activity of Daily Living ≥5 + Timed Up & Go test <20 seconds + MiniCog >2. Results: Prospective complete data were available for 625/646 consecutive patients (96.9%; 435 colon and 190 rectal cancer), 52.6% men, and median age was 79.0 years (IQR, 74.6-82.9 years). Surgery was minimally invasive in 73% of patients (321/435 colon; 135/190 rectum). At 3-6 months, 68.9%-70.3% patients experienced equal/better QoL (72.8%-72.9% colon, 60.1%-63.9% rectal cancer). At logistic regression analysis, preoperative Flemish Triage Risk Screening Tool ≥2 (3-month odds ratio [OR], 1.68; 95% CI, 1.04 to 2.73; P = .034, 6-month OR, 1.71; 95% CI, 1.06 to 2.75; P = .027) and postoperative complications (3-month OR, 2.03; 95% CI, 1.20 to 3.42; P = .008, 6-month OR, 2.56; 95% CI, 1.15 to 5.68; P = .02) are associated with decreased QoL after colectomy. Eastern Collaborative Oncology Group performance status (ECOG PS) ≥2 is a strong predictor of postoperative QoL decline in the rectal cancer subgroup (OR, 3.81; 95% CI, 1.45 to 9.92; P = .006). FR was reported by 254/323 (78.6%) patients with colon and 94/133 (70.6%) with rectal cancer. Charlson Age Comorbidity Index ≥7 (OR, 2.59; 95% CI, 1.26 to 5.32; P = .009), ECOG ≥2 (OR, 3.12; 95% CI, 1.36 to 7.20; P = .007 colon; OR, 4.61; 95% CI, 1.45 to 14.63; P = .009 rectal surgery), severe complications (OR, 17.33; 95% CI, 7.30 to 40.8; P < .001), fTRST ≥2 (OR, 2.71; 95% CI, 1.40 to 5.25; P = .003), and palliative surgery (OR, 4.11; 95% CI, 1.29 to 13.07; P = .017) are risk factors for not achieving FR. Conclusion: The majority of older patients experience good QoL and stay independent after colorectal cancer surgery. Predictors for failing to achieve these essential outcomes are now defined to guide patients' and families' preoperative counseling.| File | Dimensione | Formato | |
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