In this study we have investigated various morphofunctional features of gallbladder mucosa in patients with uncomplicated cholelithiasis. The histological changes, endocrine cell types and their distribution, and mucin-producing cells were characterized by immunocytochemistry and mucin histochemistry; moreover, we attempted to correlate these findings to the number and size of gallbladder stones and the type of bacteria present in the bile. Our results indicate that, despite similar clinical parameters, a wide range of histological changes can occur in the gallbladder mucosa of these patients. Moreover, the presence of certain endocrine and mucin-producing cell types in so-called "pyloric metaplasia" led us to hypothesize that this finding may be a trivial event in the gallbladder epithelium.
Mucin-producing cells and endocrine cells of gallbladder epithelium in patients with uncomplicated cholelithiasis / Carlei, F; Lygidakis, Nj; Barsotti, P; Crescenzi, A; Natellis, C; Carotenuto, F; Dorsi, E; Casciani, Cu. - In: HEPATO-GASTROENTEROLOGY. - ISSN 0172-6390. - 38:2(1991), pp. 149-153.
Mucin-producing cells and endocrine cells of gallbladder epithelium in patients with uncomplicated cholelithiasis.
Crescenzi A;
1991
Abstract
In this study we have investigated various morphofunctional features of gallbladder mucosa in patients with uncomplicated cholelithiasis. The histological changes, endocrine cell types and their distribution, and mucin-producing cells were characterized by immunocytochemistry and mucin histochemistry; moreover, we attempted to correlate these findings to the number and size of gallbladder stones and the type of bacteria present in the bile. Our results indicate that, despite similar clinical parameters, a wide range of histological changes can occur in the gallbladder mucosa of these patients. Moreover, the presence of certain endocrine and mucin-producing cell types in so-called "pyloric metaplasia" led us to hypothesize that this finding may be a trivial event in the gallbladder epithelium.| File | Dimensione | Formato | |
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