Botulinum toxin (BoNT) is an effective and safe therapy for the symptomatic treatment of several neurological disturbances. An important line of research has provided numerous pieces of evidence about the mechanisms of action of BoNT in the central nervous system, especially in the context of dystonia and spasticity. However, only a few studies focused on the possible central effects of BoNT in Parkinson’s disease (PD). We performed a systematic review to describe and discuss the evidence from studies focused on possible central effects of BoNT in PD animal models and PD patients. To this aim, a literature search in pubMed and SCOPUS was performed in May 2023. The records were screened according to title and abstract by two independent reviewers and relevant articles were selected for full-text review. Most of the papers highlighted by our review report that the intrastriatal administration of BoNT, through local anticholinergic action and the remodulation of striatal compensatory mechanisms secondary to dopaminergic denervation, induces an improvement in motor and non-motor symptoms in the absence of neuronal loss in animal models of PD. In human subjects, the data are scarce: a single neurophysiological study in tremulous PD patients found that the change in tremor severity after peripheral BoNT administration was associated with improved sensory–motor integration and intracortical inhibition measures. Further clinical, neurophysiological, and neuroimaging studies are necessary to clarify the possible central effects of BoNT in PD.

Exploring the central mechanisms of botulinum toxin in Parkinson’s disease: A systematic review from animal models to human evidence / Cutrona, Carolina; Marchet, Francesco; Costanzo, Matteo; DE BARTOLO, MARIA ILENIA; Leodori, Giorgio; Ferrazzano, Gina; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo; Belvisi, Daniele. - In: TOXINS. - ISSN 2072-6651. - (2023).

Exploring the central mechanisms of botulinum toxin in Parkinson’s disease: A systematic review from animal models to human evidence

Carolina Cutrona
Primo
;
Francesco Marchet
Secondo
;
Maria Ilenia De Bartolo;Giorgio Leodori;Gina Ferrazzano;Giovanni Fabbrini;Alfredo Berardelli;Daniele Belvisi
Ultimo
2023

Abstract

Botulinum toxin (BoNT) is an effective and safe therapy for the symptomatic treatment of several neurological disturbances. An important line of research has provided numerous pieces of evidence about the mechanisms of action of BoNT in the central nervous system, especially in the context of dystonia and spasticity. However, only a few studies focused on the possible central effects of BoNT in Parkinson’s disease (PD). We performed a systematic review to describe and discuss the evidence from studies focused on possible central effects of BoNT in PD animal models and PD patients. To this aim, a literature search in pubMed and SCOPUS was performed in May 2023. The records were screened according to title and abstract by two independent reviewers and relevant articles were selected for full-text review. Most of the papers highlighted by our review report that the intrastriatal administration of BoNT, through local anticholinergic action and the remodulation of striatal compensatory mechanisms secondary to dopaminergic denervation, induces an improvement in motor and non-motor symptoms in the absence of neuronal loss in animal models of PD. In human subjects, the data are scarce: a single neurophysiological study in tremulous PD patients found that the change in tremor severity after peripheral BoNT administration was associated with improved sensory–motor integration and intracortical inhibition measures. Further clinical, neurophysiological, and neuroimaging studies are necessary to clarify the possible central effects of BoNT in PD.
2023
botulinum toxin; Parkinson’s disease; central nervous system; animal models
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Exploring the central mechanisms of botulinum toxin in Parkinson’s disease: A systematic review from animal models to human evidence / Cutrona, Carolina; Marchet, Francesco; Costanzo, Matteo; DE BARTOLO, MARIA ILENIA; Leodori, Giorgio; Ferrazzano, Gina; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo; Belvisi, Daniele. - In: TOXINS. - ISSN 2072-6651. - (2023).
File allegati a questo prodotto
File Dimensione Formato  
toxins-16-00009 (1).pdf

accesso aperto

Note: Cutrona_Exploring the Central Mechanisms_2023
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 723.68 kB
Formato Adobe PDF
723.68 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1699126
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact