Background: Despite second-line transplant(SLT) for recurrent hepatocellular carcinoma(rHCC) leads to the longest survival after recurrence(SAR), its real applicability has never been reported. The aim was to compare the SAR of SLT versus repeated hepatectomy and thermoablation(CUR group). Methods: Patients were enrolled from the Italian register HE.RC.O.LE.S. between 2008 and 2021. Two groups were created: CUR versus SLT. A propensity score matching (PSM) was run to balance the groups. Results: 743 patients were enrolled, CUR = 611 and SLT = 132. Median age at recurrence was 71(IQR 6575) years old and 60(IQR 53-64, p < 0.001) for CUR and SLT respectively. After PSM, median SAR for CUR was 43 months(95%CI = 37 - 93) and not reached for SLT(p < 0.001). SLT patients gained a survival benefit of 9.4 months if compared with CUR. MilanCriteria(MC)-In patients were 82.7% of the CUR group. SLT(HR 0.386, 95%CI = 0.23 - 0.63, p < 0.001) and the MELD score(HR 1.169, 95%CI = 1.07 - 1.27, p < 0.001) were the only predictors of mortality. In case of MC-Out, the only predictor of mortality was the number of nodules at recurrence(HR 1.45, 95%CI= 1.09 - 1.93, p = 0.011). Conclusion: It emerged an important transplant under referral in favour of repeated hepatectomy or thermoablation. In patients with MC-Out relapse, the benefit of SLT over CUR was not observed.

Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario / Famularo, Simone; Cillo, Umberto; Lauterio, Andrea; Donadon, Matteo; Vitale, Alessandro; Serenari, Matteo; Cipriani, Federica; Fazio, Federico; Giuffrida, Mario; Ardito, Francesco; Dominioni, Tommaso; Garancini, Mattia; Lai, Quirino; Nicolini, Daniele; Molfino, Sarah; Perri, Pasquale; Pinotti, Enrico; Conci, Simone; Ferrari, Cecilia; Zanello, Matteo; Patauner, Stefan; Zimmitti, Giuseppe; Germani, Paola; Chiarelli, Marco; Romano, Maurizio; DE ANGELIS, Michela; La Barba, Giuliano; Troci, Albert; Ferraro, Valentina; Izzo, Francesco; Antonucci, Adelmo; Belli, Andrea; Memeo, Riccardo; Crespi, Michele; Ercolani, Giorgio; Boccia, Luigi; Zanus, Giacomo; Tarchi, Paola; Abu Hilal, Moh'D; Frena, Antonio; Jovine, Elio; Griseri, Guido; Ruzzenente, Andrea; Zago, Mauro; Grazi, Gianluca; L Baiocchi, Gian; Vivarelli, Marco; Rossi, Massimo; Romano, Fabrizio; Maestri, Marcello; Giuliante, Felice; D Valle, Raffaele; Ferrero, Alessandro; Aldrighetti, Luca; De Carlis, Luciano; Cescon, Matteo; Torzilli, Guido; Milana, Flavio; Bertacco, Alessandra; De Carlis, Riccardo; Ratti, Francesca; Russolillo, Nadia; Iaria, Maurizio; Razionale, Francesco; Tartaglia, Giuseppe; Ciulli, Cristina; Carissimi, Francesca; LARGHI LAUREIRO, Zoe; Marinelli, Laura; Depeppo, Valerio; Montuori, Mauro; Marchitelli, Ivan; Franceschi, Angelo; Notte, Francesca; Manzoni, Alberto; Cosola, Davide; Corleone, Pio; Fumagalli, Luca; Salvador, Luca; Mantovani, Guido; Cucchetti, Alessandro; Cammarata, Francesco; Conticchio, Maria; Patrone, Renato; P Bernasconi, Davide. - In: HPB. - ISSN 1365-182X. - (2023).

Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario

Alessandro Vitale;Federico Fazio;Quirino Lai;Pasquale Perri;Michela De Angelis;Marco Vivarelli;Fabrizio Romano;Flavio Milana;Giuseppe Tartaglia;Zoe Larghi Laureiro;
2023

Abstract

Background: Despite second-line transplant(SLT) for recurrent hepatocellular carcinoma(rHCC) leads to the longest survival after recurrence(SAR), its real applicability has never been reported. The aim was to compare the SAR of SLT versus repeated hepatectomy and thermoablation(CUR group). Methods: Patients were enrolled from the Italian register HE.RC.O.LE.S. between 2008 and 2021. Two groups were created: CUR versus SLT. A propensity score matching (PSM) was run to balance the groups. Results: 743 patients were enrolled, CUR = 611 and SLT = 132. Median age at recurrence was 71(IQR 6575) years old and 60(IQR 53-64, p < 0.001) for CUR and SLT respectively. After PSM, median SAR for CUR was 43 months(95%CI = 37 - 93) and not reached for SLT(p < 0.001). SLT patients gained a survival benefit of 9.4 months if compared with CUR. MilanCriteria(MC)-In patients were 82.7% of the CUR group. SLT(HR 0.386, 95%CI = 0.23 - 0.63, p < 0.001) and the MELD score(HR 1.169, 95%CI = 1.07 - 1.27, p < 0.001) were the only predictors of mortality. In case of MC-Out, the only predictor of mortality was the number of nodules at recurrence(HR 1.45, 95%CI= 1.09 - 1.93, p = 0.011). Conclusion: It emerged an important transplant under referral in favour of repeated hepatectomy or thermoablation. In patients with MC-Out relapse, the benefit of SLT over CUR was not observed.
2023
hepatocellular carcinoma; survival benefit; liver resection; liver transplant
01 Pubblicazione su rivista::01a Articolo in rivista
Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario / Famularo, Simone; Cillo, Umberto; Lauterio, Andrea; Donadon, Matteo; Vitale, Alessandro; Serenari, Matteo; Cipriani, Federica; Fazio, Federico; Giuffrida, Mario; Ardito, Francesco; Dominioni, Tommaso; Garancini, Mattia; Lai, Quirino; Nicolini, Daniele; Molfino, Sarah; Perri, Pasquale; Pinotti, Enrico; Conci, Simone; Ferrari, Cecilia; Zanello, Matteo; Patauner, Stefan; Zimmitti, Giuseppe; Germani, Paola; Chiarelli, Marco; Romano, Maurizio; DE ANGELIS, Michela; La Barba, Giuliano; Troci, Albert; Ferraro, Valentina; Izzo, Francesco; Antonucci, Adelmo; Belli, Andrea; Memeo, Riccardo; Crespi, Michele; Ercolani, Giorgio; Boccia, Luigi; Zanus, Giacomo; Tarchi, Paola; Abu Hilal, Moh'D; Frena, Antonio; Jovine, Elio; Griseri, Guido; Ruzzenente, Andrea; Zago, Mauro; Grazi, Gianluca; L Baiocchi, Gian; Vivarelli, Marco; Rossi, Massimo; Romano, Fabrizio; Maestri, Marcello; Giuliante, Felice; D Valle, Raffaele; Ferrero, Alessandro; Aldrighetti, Luca; De Carlis, Luciano; Cescon, Matteo; Torzilli, Guido; Milana, Flavio; Bertacco, Alessandra; De Carlis, Riccardo; Ratti, Francesca; Russolillo, Nadia; Iaria, Maurizio; Razionale, Francesco; Tartaglia, Giuseppe; Ciulli, Cristina; Carissimi, Francesca; LARGHI LAUREIRO, Zoe; Marinelli, Laura; Depeppo, Valerio; Montuori, Mauro; Marchitelli, Ivan; Franceschi, Angelo; Notte, Francesca; Manzoni, Alberto; Cosola, Davide; Corleone, Pio; Fumagalli, Luca; Salvador, Luca; Mantovani, Guido; Cucchetti, Alessandro; Cammarata, Francesco; Conticchio, Maria; Patrone, Renato; P Bernasconi, Davide. - In: HPB. - ISSN 1365-182X. - (2023).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1699022
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