The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirec-tional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.

Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy / Lo Iacono, M.; Modica, C.; Porcelli, G.; Brancato, O. R.; Muratore, G.; Bianca, P.; Gaggianesi, M.; Turdo, A.; Veschi, V.; Todaro, M.; Di Franco, S.; Stassi, G.. - In: BIOMOLECULES. - ISSN 2218-273X. - 12:5(2022). [10.3390/biom12050702]

Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy

Gaggianesi M.;Turdo A.;Veschi V.;Di Franco S.;
2022

Abstract

The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirec-tional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.
2022
adipokines; adipose tissue; cancer stem cells; exosomes; target therapy; tumor microenvironment
01 Pubblicazione su rivista::01a Articolo in rivista
Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy / Lo Iacono, M.; Modica, C.; Porcelli, G.; Brancato, O. R.; Muratore, G.; Bianca, P.; Gaggianesi, M.; Turdo, A.; Veschi, V.; Todaro, M.; Di Franco, S.; Stassi, G.. - In: BIOMOLECULES. - ISSN 2218-273X. - 12:5(2022). [10.3390/biom12050702]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1698864
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