Alcohol abuse is still one of the leading causes of death worldwide. Early diagnosis of alcohol abuse enables preventive intervention on the effects and risks associated with its consumption. Carbohydrate-deficient transferrin (CDT) is one of the most reliable biomarkers of chronic alcohol misuse. We retrospectively studied a population of 12,624 subjects who had their driving license suspended for driving under the influence of alcohol or drugs from 2016 to 2022. The analytical determination of CDT was performed following a certified high-performance liquid chromatography (HPLC) method. Data were split by year, age and gender. The majority of subjects with positive ÍT were male, although the trend of positivity was similar between males and females. A steady increase in both the number of tests performed and the number of positives was observed over the years. Patients aged 41–50 years had the highest prevalence, followed by 51–60, 31–40 and 18–30 years. CDT continues to be a steady marker for diagnosis of alcohol abuse in the majority of cases. Data emerging from our study are in line with the increasing national trends on traffic accidents, injuries and deaths related to alcohol and drug DUI (driving under the influence), requiring the implementation of preventive measures to limit this ever-growing phenomenon.

Carbohydrate-deficient transferrin (cdt) as a biomarker of alcohol abuse. A retrospective study of the Italian drinking trend among drivers from 2016 to 2022 / Fiorelli, D.; Romani, L.; Treglia, M.; Pallocci, M.; Passalacqua, P.; Coppeta, L.; Marsella, L. T.; Tittarelli, R.. - In: TOXICS. - ISSN 2305-6304. - 11:11(2023), pp. 1-11. [10.3390/toxics11110914]

Carbohydrate-deficient transferrin (cdt) as a biomarker of alcohol abuse. A retrospective study of the Italian drinking trend among drivers from 2016 to 2022

Passalacqua P.;
2023

Abstract

Alcohol abuse is still one of the leading causes of death worldwide. Early diagnosis of alcohol abuse enables preventive intervention on the effects and risks associated with its consumption. Carbohydrate-deficient transferrin (CDT) is one of the most reliable biomarkers of chronic alcohol misuse. We retrospectively studied a population of 12,624 subjects who had their driving license suspended for driving under the influence of alcohol or drugs from 2016 to 2022. The analytical determination of CDT was performed following a certified high-performance liquid chromatography (HPLC) method. Data were split by year, age and gender. The majority of subjects with positive ÍT were male, although the trend of positivity was similar between males and females. A steady increase in both the number of tests performed and the number of positives was observed over the years. Patients aged 41–50 years had the highest prevalence, followed by 51–60, 31–40 and 18–30 years. CDT continues to be a steady marker for diagnosis of alcohol abuse in the majority of cases. Data emerging from our study are in line with the increasing national trends on traffic accidents, injuries and deaths related to alcohol and drug DUI (driving under the influence), requiring the implementation of preventive measures to limit this ever-growing phenomenon.
2023
alcohol abuse; carbohydrate-deficient transferrin (cdt); driving under the influence of alcohol; high-performance liquid chromatography (hplc)
01 Pubblicazione su rivista::01a Articolo in rivista
Carbohydrate-deficient transferrin (cdt) as a biomarker of alcohol abuse. A retrospective study of the Italian drinking trend among drivers from 2016 to 2022 / Fiorelli, D.; Romani, L.; Treglia, M.; Pallocci, M.; Passalacqua, P.; Coppeta, L.; Marsella, L. T.; Tittarelli, R.. - In: TOXICS. - ISSN 2305-6304. - 11:11(2023), pp. 1-11. [10.3390/toxics11110914]
File allegati a questo prodotto
File Dimensione Formato  
Fiorelli_Carbohydrate-deficient-transferrin_2023.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.57 MB
Formato Adobe PDF
1.57 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1697964
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact