The current SARS-CoV-2 pandemic and the likelihood thatnew coronavirusstrains will emerge in the immediate future point out the urgent needto identify new pan-coronavirus inhibitors. Strigolactones (SLs) area class of plant hormones with multifaceted activities whose rolesin plant-related fields have been extensively explored. Recently,we proved that SLs also exert antiviral activity toward herpesviruses,such as human cytomegalovirus (HCMV). Here we show that the syntheticSLs TH-EGO and EDOT-EGO impair & beta;-coronavirus replication includingSARS-CoV-2 and the common cold human coronavirus HCoV-OC43. Interestingly, in silico simulations suggest the binding of SLs in theSARS-CoV-2 main protease (M-pro) active site, and this wasfurther confirmed by an in vitro activity assay.Overall, our results highlight the potential efficacy of SLs as broad-spectrumantivirals against & beta;-coronaviruses, which may provide the rationalefor repurposing this class of hormones for the treatment of COVID-19patients.

Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting the main protease mpro / Biolatti, Matteo; Blangetti, Marco; Baggieri, Melissa; Marchi, Antonella; Gioacchini, Silvia; Bajetto, Greta; Arnodo, Davide; Bucci, Paola; Fioravanti, Raoul; Kojouri, Maedeh; Bersani, Matteo; D'Arrigo, Giulia; Siragusa, Lydia; Ghinato, Simone; De Andrea, Marco; Gugliesi, Francesca; Albano, Camilla; Pasquero, Selina; Visentin, Ivan; D'Ugo, Emilio; Esposito, Francesca; Malune, Paolo; Tramontano, Enzo; Prandi, Cristina; Spyrakis, Francesca; Magurano, Fabio; Dell'Oste, Valentina. - In: ACS INFECTIOUS DISEASES. - ISSN 2373-8227. - 9:7(2023), pp. 1310-1318. [10.1021/acsinfecdis.3c00219]

Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting the main protease mpro

Silvia Gioacchini;Raoul Fioravanti;Maedeh Kojouri;
2023

Abstract

The current SARS-CoV-2 pandemic and the likelihood thatnew coronavirusstrains will emerge in the immediate future point out the urgent needto identify new pan-coronavirus inhibitors. Strigolactones (SLs) area class of plant hormones with multifaceted activities whose rolesin plant-related fields have been extensively explored. Recently,we proved that SLs also exert antiviral activity toward herpesviruses,such as human cytomegalovirus (HCMV). Here we show that the syntheticSLs TH-EGO and EDOT-EGO impair & beta;-coronavirus replication includingSARS-CoV-2 and the common cold human coronavirus HCoV-OC43. Interestingly, in silico simulations suggest the binding of SLs in theSARS-CoV-2 main protease (M-pro) active site, and this wasfurther confirmed by an in vitro activity assay.Overall, our results highlight the potential efficacy of SLs as broad-spectrumantivirals against & beta;-coronaviruses, which may provide the rationalefor repurposing this class of hormones for the treatment of COVID-19patients.
2023
antiviral screening; strigolactones; hcov-oc43; sars-cov-2; m-pro
01 Pubblicazione su rivista::01f Lettera, Nota
Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting the main protease mpro / Biolatti, Matteo; Blangetti, Marco; Baggieri, Melissa; Marchi, Antonella; Gioacchini, Silvia; Bajetto, Greta; Arnodo, Davide; Bucci, Paola; Fioravanti, Raoul; Kojouri, Maedeh; Bersani, Matteo; D'Arrigo, Giulia; Siragusa, Lydia; Ghinato, Simone; De Andrea, Marco; Gugliesi, Francesca; Albano, Camilla; Pasquero, Selina; Visentin, Ivan; D'Ugo, Emilio; Esposito, Francesca; Malune, Paolo; Tramontano, Enzo; Prandi, Cristina; Spyrakis, Francesca; Magurano, Fabio; Dell'Oste, Valentina. - In: ACS INFECTIOUS DISEASES. - ISSN 2373-8227. - 9:7(2023), pp. 1310-1318. [10.1021/acsinfecdis.3c00219]
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