Natural products are a rich source of bioactive molecules that have potential pharmacotherapeutic applications. In this study, we focused on Artemisia annua (A. annua) and its enriched extracts which were biologically evaluated in vitro as virucidal, antiviral, and antioxidant agents, with a potential application against the COVID-19 infection. The crude extract showed virucidal, antiviral and antioxidant effects in concentrations that did not affect cell viability. Scopoletin, arteannuin B and artemisinic acid (single fractions isolated from A. annua) exerted a considerable virucidal and antiviral effect in vitro starting from a concentration of 50 µg/mL. Data from Surface Plasmon Resonance (SPR) showed that the inhibition of the viral infection was due to the interaction of these compounds with the 3CLpro and Spike proteins of SARS-CoV-2, suggesting that the main interaction of compounds may interfere with the viral pathways during the insertion and the replication process. The present study suggests that natural extract of A. annua and its components could have a key role as antioxidants and antiviral agents and support the fight against SARS-CoV-2 variants and other possible emerging Coronaviruses.

Antiviral, virucidal and antioxidant properties of artemisia annua against {SARS}-{CoV}-2 / Baggieri, Melissa; Gioacchini, Silvia; Borgonovo, Gigliola; Catinella, Giorgia; Marchi, Antonella; Picone, Pasquale; Vasto, Sonya; Fioravanti, Raoul; Bucci, Paola; Kojouri, Maedeh; Giuseppetti, Roberto; D'Ugo, Emilio; Ubaldi, Fausto; Dallavalle, Sabrina; Nuzzo, Domenico; Pinto, Andrea; Magurano, Fabio. - In: BIOMÉDECINE & PHARMACOTHÉRAPIE. - ISSN 0753-3322. - 168:(2023), pp. 1-12. [10.1016/j.biopha.2023.115682]

Antiviral, virucidal and antioxidant properties of artemisia annua against {SARS}-{CoV}-2

Silvia Gioacchini;Raoul Fioravanti;Maedeh Kojouri;
2023

Abstract

Natural products are a rich source of bioactive molecules that have potential pharmacotherapeutic applications. In this study, we focused on Artemisia annua (A. annua) and its enriched extracts which were biologically evaluated in vitro as virucidal, antiviral, and antioxidant agents, with a potential application against the COVID-19 infection. The crude extract showed virucidal, antiviral and antioxidant effects in concentrations that did not affect cell viability. Scopoletin, arteannuin B and artemisinic acid (single fractions isolated from A. annua) exerted a considerable virucidal and antiviral effect in vitro starting from a concentration of 50 µg/mL. Data from Surface Plasmon Resonance (SPR) showed that the inhibition of the viral infection was due to the interaction of these compounds with the 3CLpro and Spike proteins of SARS-CoV-2, suggesting that the main interaction of compounds may interfere with the viral pathways during the insertion and the replication process. The present study suggests that natural extract of A. annua and its components could have a key role as antioxidants and antiviral agents and support the fight against SARS-CoV-2 variants and other possible emerging Coronaviruses.
2023
antioxidant activity; antiviral; artemisia annua; artemisinic acid; covid-19; sars-cov2
01 Pubblicazione su rivista::01a Articolo in rivista
Antiviral, virucidal and antioxidant properties of artemisia annua against {SARS}-{CoV}-2 / Baggieri, Melissa; Gioacchini, Silvia; Borgonovo, Gigliola; Catinella, Giorgia; Marchi, Antonella; Picone, Pasquale; Vasto, Sonya; Fioravanti, Raoul; Bucci, Paola; Kojouri, Maedeh; Giuseppetti, Roberto; D'Ugo, Emilio; Ubaldi, Fausto; Dallavalle, Sabrina; Nuzzo, Domenico; Pinto, Andrea; Magurano, Fabio. - In: BIOMÉDECINE & PHARMACOTHÉRAPIE. - ISSN 0753-3322. - 168:(2023), pp. 1-12. [10.1016/j.biopha.2023.115682]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1697932
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