Background: COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm. Methods: We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group. Results: Sepsis associated with covid-19 infection has some similarities and differences from that from other causes. Conclusion: In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.
The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis. A comparison between SARS-COV-2-related sepsis and sepsis from other causes / Piccioni, Andrea; Franza, Laura; Rosa, Federico; Candelli, Marcello; Covino, Marcello; Ferrara, Michela; Volonnino, Gianpietro; Bertozzi, Giuseppe; Vittoria Zamponi, Maria; Maiese, Aniello; Savioli, Gabriele; Franceschi, Francesco; La Russa, Raffaele. - In: INFECTIOUS MEDICINE. - ISSN 2772-431X. - 2:3(2023), pp. 202-211. [10.1016/j.imj.2023.04.006]
The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis. A comparison between SARS-COV-2-related sepsis and sepsis from other causes
Ferrara, Michela;Volonnino, Gianpietro;Vittoria Zamponi, Maria;
2023
Abstract
Background: COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm. Methods: We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group. Results: Sepsis associated with covid-19 infection has some similarities and differences from that from other causes. Conclusion: In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.| File | Dimensione | Formato | |
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