Background: Radiation therapy (RT) is a key anti-cancer treatment that involves using ionizing radiation to kill tumor cells. However, this therapy can lead to short- and long-term adverse effects due to radiation exposure of surrounding normal tissue. The type of DNA damage inflicted by radiation therapy determines its effectiveness. High levels of genotoxic damage can lead to cell cycle arrest, senescence, and cell death, but many tumors can cope with this damage by activating protective mechanisms. Intrinsic and acquired radioresistance are major causes of tumor recurrence, and understanding these mechanisms is crucial for cancer therapy. The mechanisms behind radioresistance involve processes like hypoxia response, cell proliferation, DNA repair, apoptosis inhibition, and autophagy. Conclusion: Here we briefly review the role of genetic and epigenetic factors involved in the modulation of DNA repair and DNA damage response that promote radioresistance. In addition, leveraging our recent results on the effects of low dose rate (LDR) of ionizing radiation on Drosophila melanogaster we discuss how this model organism can be instrumental in the identification of conserved factors involved in the tumor resistance to RT.

DNA repair in tumor radioresistance: insights from fruit flies genetics / Porrazzo, Antonella; Cassandri, Matteo; D'Alessandro, Andrea; Morciano, Patrizia; Rota, Rossella; Marampon, Francesco; Cenci, Giovanni. - In: CELLULAR ONCOLOGY. - ISSN 2211-3428. - (2023). [10.1007/s13402-023-00906-6]

DNA repair in tumor radioresistance: insights from fruit flies genetics

Porrazzo, Antonella
Co-primo
;
Cassandri, Matteo
Co-primo
;
D'Alessandro, Andrea
Investigation
;
Morciano, Patrizia;Marampon, Francesco;Cenci, Giovanni
Ultimo
2023

Abstract

Background: Radiation therapy (RT) is a key anti-cancer treatment that involves using ionizing radiation to kill tumor cells. However, this therapy can lead to short- and long-term adverse effects due to radiation exposure of surrounding normal tissue. The type of DNA damage inflicted by radiation therapy determines its effectiveness. High levels of genotoxic damage can lead to cell cycle arrest, senescence, and cell death, but many tumors can cope with this damage by activating protective mechanisms. Intrinsic and acquired radioresistance are major causes of tumor recurrence, and understanding these mechanisms is crucial for cancer therapy. The mechanisms behind radioresistance involve processes like hypoxia response, cell proliferation, DNA repair, apoptosis inhibition, and autophagy. Conclusion: Here we briefly review the role of genetic and epigenetic factors involved in the modulation of DNA repair and DNA damage response that promote radioresistance. In addition, leveraging our recent results on the effects of low dose rate (LDR) of ionizing radiation on Drosophila melanogaster we discuss how this model organism can be instrumental in the identification of conserved factors involved in the tumor resistance to RT.
2023
DNA repair; Drosophila; Radiobiology; Radioresistance; Radiotherapy
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
DNA repair in tumor radioresistance: insights from fruit flies genetics / Porrazzo, Antonella; Cassandri, Matteo; D'Alessandro, Andrea; Morciano, Patrizia; Rota, Rossella; Marampon, Francesco; Cenci, Giovanni. - In: CELLULAR ONCOLOGY. - ISSN 2211-3428. - (2023). [10.1007/s13402-023-00906-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1696386
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