Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers, but only a small proportion of oral potentially malignant disorders and oral squamous cell carcinoma. The aim of our study was to investigate the presence of HPV-DNA in oral diseases. Methods: This was a cross-sectional-study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy/histopathological examination and a brush biopsy for HPV-DNA detection/genotyping by real-time polymerase-chainreaction. Immunohistochemistry was used to assess p16INK4a expression. Results: HPV was identified in 15/99 (15.2%) patients (males:66.6%). Patients with oral lichen planus (OLP;23.8%), oral leukoplakia (OL;17.5%), and conditions of the buccal mucosa (BM;17.5%) had the highest rate of infection. Most patients with high-risk-HPV infection presented with OLP (19.1%), whereas most of the patients with low-risk-HPV infections had epithelial hyperkeratosis-non-reactive (9.4%). Amongst all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mildepithelial-dysplasia had a positive p16INK4a expression.
Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study / Fantozzi, Paolo Junior; Romeo, Umberto; Tenore, Gianluca; Palaia, Gaspare; Ciolfi, Chiara; Pierangeli, Alessandra; DI GIOIA, Cira Rosaria Tiziana; Villa, Alessandro. - In: JADA FOUNDATIONAL SCIENCE. - ISSN 2772-414X. - (2024). [10.1016/j.jfscie.2024.100031]
Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study.
Paolo Junior FantozziPrimo
Writing – Original Draft Preparation
;Umberto RomeoSecondo
Writing – Review & Editing
;Gianluca TenoreWriting – Review & Editing
;Gaspare PalaiaWriting – Review & Editing
;Chiara CiolfiData Curation
;Alessandra PierangeliWriting – Review & Editing
;Cira Rosaria Tiziana Di GioiaPenultimo
Writing – Review & Editing
;
2024
Abstract
Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers, but only a small proportion of oral potentially malignant disorders and oral squamous cell carcinoma. The aim of our study was to investigate the presence of HPV-DNA in oral diseases. Methods: This was a cross-sectional-study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy/histopathological examination and a brush biopsy for HPV-DNA detection/genotyping by real-time polymerase-chainreaction. Immunohistochemistry was used to assess p16INK4a expression. Results: HPV was identified in 15/99 (15.2%) patients (males:66.6%). Patients with oral lichen planus (OLP;23.8%), oral leukoplakia (OL;17.5%), and conditions of the buccal mucosa (BM;17.5%) had the highest rate of infection. Most patients with high-risk-HPV infection presented with OLP (19.1%), whereas most of the patients with low-risk-HPV infections had epithelial hyperkeratosis-non-reactive (9.4%). Amongst all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mildepithelial-dysplasia had a positive p16INK4a expression.File | Dimensione | Formato | |
---|---|---|---|
Fantozzi_Detection_2024.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
413.07 kB
Formato
Adobe PDF
|
413.07 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.