Background: Percutaneous ethanol injection (PEI) is used for the treatment of benign cystic thyroid nodules. This systematic review and meta-analysis aimed to obtain strong evidence of its long-term efficacy and safety. Methods: PubMed, CENTRAL, Scopus and Web of Science databases were searched until November 2020 for studies reporting data on volume reduction rate (VRR), compressive symptoms and cosmetic concerns. Associated complications were assessed. A random-effects model was designed to pool the data. Results: Out of 385 papers, nine studies evaluating 1667 nodules were finally included. Overall, VRR at 6, 12, 24, 36, 60 and 120 months was 77%, 81%, 72%, 68%, 74% and 69%, respectively. Significant reductions in the compressive symptoms and cosmetic concerns were observed. No permanent complications were observed. Conclusions: The present meta-analysis showed that PEI could significantly reduce the volume of benign cystic thyroid nodules. This reduction was already effective at 6 months post-treatment, and the effect was stable over time.

Long-term efficacy and safety of percutaneous ethanol injection (PEI) in cystic thyroid nodules: A systematic review and meta-analysis / Cesareo, R.; Tabacco, G.; Naciu, A. M.; Crescenzi, A.; Bernardi, S.; Romanelli, F.; Deandrea, M.; Trimboli, P.; Palermo, A.; Castellana, M.. - In: CLINICAL ENDOCRINOLOGY. - ISSN 0300-0664. - 96:2(2022), pp. 97-106. [10.1111/cen.14530]

Long-term efficacy and safety of percutaneous ethanol injection (PEI) in cystic thyroid nodules: A systematic review and meta-analysis

Cesareo R.
Primo
;
Crescenzi A.;Romanelli F.;Castellana M.
Ultimo
2022

Abstract

Background: Percutaneous ethanol injection (PEI) is used for the treatment of benign cystic thyroid nodules. This systematic review and meta-analysis aimed to obtain strong evidence of its long-term efficacy and safety. Methods: PubMed, CENTRAL, Scopus and Web of Science databases were searched until November 2020 for studies reporting data on volume reduction rate (VRR), compressive symptoms and cosmetic concerns. Associated complications were assessed. A random-effects model was designed to pool the data. Results: Out of 385 papers, nine studies evaluating 1667 nodules were finally included. Overall, VRR at 6, 12, 24, 36, 60 and 120 months was 77%, 81%, 72%, 68%, 74% and 69%, respectively. Significant reductions in the compressive symptoms and cosmetic concerns were observed. No permanent complications were observed. Conclusions: The present meta-analysis showed that PEI could significantly reduce the volume of benign cystic thyroid nodules. This reduction was already effective at 6 months post-treatment, and the effect was stable over time.
2022
cystic thyroid nodules; meta-analysis; percutaneous ethanol injection; volume reduction rate
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Long-term efficacy and safety of percutaneous ethanol injection (PEI) in cystic thyroid nodules: A systematic review and meta-analysis / Cesareo, R.; Tabacco, G.; Naciu, A. M.; Crescenzi, A.; Bernardi, S.; Romanelli, F.; Deandrea, M.; Trimboli, P.; Palermo, A.; Castellana, M.. - In: CLINICAL ENDOCRINOLOGY. - ISSN 0300-0664. - 96:2(2022), pp. 97-106. [10.1111/cen.14530]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1696142
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